Showing Protein Very-long-chain 3-oxoacyl-CoA reductase (BMDBP00927)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00927 |
| Secondary Accession Numbers | None |
| Name | Very-long-chain 3-oxoacyl-CoA reductase |
| Synonyms | Not Available |
| Gene Name | HSD17B12 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in binding |
| Specific Function | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 15 |
| Locus | Not Available |
| SNPs | HSD17B12 |
| Gene Sequence |
>939 bp ATGGAGACAGCTCTGCCTGCAGCGGGCTTCCTGTACTGGGTGGGCGCGAGCACCGTGGCC TACCTGGCTCTGCGCATCTCGTGCTGGTTCTTCACGGCCCTTCGGGTCTGGGGTTTGGGT CACGAGGCGGGGGTCGGCCCGTGGCTCGGTGAATGGGCAGTTGTCACAGGTGGTACTGAT GGAATTGGAAAATCATATGCAGAAGAGTTAGCAAAGCGTGGCATGAAGATTGTCCTTATC AGCAGATCCCAGGACAAACTGGACCAGGTTTCCAGTGAAATAAGTGAAAAATTCAAAGTG GAAACAAAGACCATTGCTGTTGACTTTACATCAGAAGATATTTATGATAAAATTAAAGCA AGCTTGGCAGGTCTTAATATTGGTGTTTTAGTGAACAATGTGGGAATGTCATACGAATAT CCAGAATACTTTTTGGACGTTCCTGACTTGGACAATACCATCAAGAAACTGATAACTGTC AATGCTCTTTCTGTTTGTAAGATGACACGGTTGGTACTGCCTGGCATGGTAGAAAGATCT AAAGGGGCAATTCTGAACATCTCCTCTGCCAGTGGCATGTACCCAGTTCCACTGCTGACC ATCTACTCTGCAACCAAGGCTTTTGTAGATTTCTTCTCTCAGTGCCTCCATGAGGAATAT AAGAGCAAGGGCGTCATTGTGCAGAGTGTCCTGCCCTACTATGTCGCCACAAAACTGGCT AAAATTAAAAGGCCAACTTGGGACAAGCCCTCTCCAGAGACGTTTGTGAAGTCTGCAATG AAAACCATCGGCGTGCAATCTCGAACCAACGGATACCCGATCCATTCTCTTGTGGCCTCA GTAAGCGCAAGCCTGCCTTCCTGGCTGTATTTCAAAATCGCCATGTATTCAGGCAACTCC ATACGGGTTCGCTATCTGAAGAAAATGAAGATGAACTAA |
| Protein Properties | |
| Number of Residues | 312 |
| Molecular Weight | 34495.0 |
| Theoretical pI | 9.68 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Estradiol 17-beta-dehydrogenase 12 METALPAAGFLYWVGASTVAYLALRISCWFFTALRVWGLGHEAGVGPWLGEWAVVTGGTD GIGKSYAEELAKRGMKIVLISRSQDKLDQVSSEISEKFKVETKTIAVDFTSEDIYDKIKA SLAGLNIGVLVNNVGMSYEYPEYFLDVPDLDNTIKKLITVNALSVCKMTRLVLPGMVERS KGAILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGVIVQSVLPYYVATKLA KIKRPTWDKPSPETFVKSAMKTIGVQSRTNGYPIHSLVASVSASLPSWLYFKIAMYSGNS IRVRYLKKMKMN |
| External Links | |
| GenBank ID Protein | AAX08960.1 |
| UniProtKB/Swiss-Prot ID | Q5E9H7 |
| UniProtKB/Swiss-Prot Entry Name | DHB12_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT020943 |
| GeneCard ID | HSD17B12 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |