| Identification |
|---|
| BMDB Protein ID
| BMDBP00927 |
| Secondary Accession Numbers
| None |
| Name
| Very-long-chain 3-oxoacyl-CoA reductase |
| Synonyms
|
Not Available
|
| Gene Name
| HSD17B12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. |
| Pathways
|
- Androgen and Estrogen Metabolism
- Androstenedione Metabolism
- Estrogen biosynthesis
- Fatty Acid Biosynthesis
- Lipid metabolism
- Steroid Biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| HSD17B12 |
| Gene Sequence
|
>939 bp
ATGGAGACAGCTCTGCCTGCAGCGGGCTTCCTGTACTGGGTGGGCGCGAGCACCGTGGCC
TACCTGGCTCTGCGCATCTCGTGCTGGTTCTTCACGGCCCTTCGGGTCTGGGGTTTGGGT
CACGAGGCGGGGGTCGGCCCGTGGCTCGGTGAATGGGCAGTTGTCACAGGTGGTACTGAT
GGAATTGGAAAATCATATGCAGAAGAGTTAGCAAAGCGTGGCATGAAGATTGTCCTTATC
AGCAGATCCCAGGACAAACTGGACCAGGTTTCCAGTGAAATAAGTGAAAAATTCAAAGTG
GAAACAAAGACCATTGCTGTTGACTTTACATCAGAAGATATTTATGATAAAATTAAAGCA
AGCTTGGCAGGTCTTAATATTGGTGTTTTAGTGAACAATGTGGGAATGTCATACGAATAT
CCAGAATACTTTTTGGACGTTCCTGACTTGGACAATACCATCAAGAAACTGATAACTGTC
AATGCTCTTTCTGTTTGTAAGATGACACGGTTGGTACTGCCTGGCATGGTAGAAAGATCT
AAAGGGGCAATTCTGAACATCTCCTCTGCCAGTGGCATGTACCCAGTTCCACTGCTGACC
ATCTACTCTGCAACCAAGGCTTTTGTAGATTTCTTCTCTCAGTGCCTCCATGAGGAATAT
AAGAGCAAGGGCGTCATTGTGCAGAGTGTCCTGCCCTACTATGTCGCCACAAAACTGGCT
AAAATTAAAAGGCCAACTTGGGACAAGCCCTCTCCAGAGACGTTTGTGAAGTCTGCAATG
AAAACCATCGGCGTGCAATCTCGAACCAACGGATACCCGATCCATTCTCTTGTGGCCTCA
GTAAGCGCAAGCCTGCCTTCCTGGCTGTATTTCAAAATCGCCATGTATTCAGGCAACTCC
ATACGGGTTCGCTATCTGAAGAAAATGAAGATGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 312 |
| Molecular Weight
| 34495.0 |
| Theoretical pI
| 9.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Estradiol 17-beta-dehydrogenase 12
METALPAAGFLYWVGASTVAYLALRISCWFFTALRVWGLGHEAGVGPWLGEWAVVTGGTD
GIGKSYAEELAKRGMKIVLISRSQDKLDQVSSEISEKFKVETKTIAVDFTSEDIYDKIKA
SLAGLNIGVLVNNVGMSYEYPEYFLDVPDLDNTIKKLITVNALSVCKMTRLVLPGMVERS
KGAILNISSASGMYPVPLLTIYSATKAFVDFFSQCLHEEYKSKGVIVQSVLPYYVATKLA
KIKRPTWDKPSPETFVKSAMKTIGVQSRTNGYPIHSLVASVSASLPSWLYFKIAMYSGNS
IRVRYLKKMKMN
|
| External Links |
|---|
| GenBank ID Protein
| AAX08960.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9H7 |
| UniProtKB/Swiss-Prot Entry Name
| DHB12_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020943 |
| GeneCard ID
| HSD17B12 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
