Showing Protein Tryptophan--tRNA ligase, cytoplasmic (BMDBP00928)
| Identification | |||
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| BMDB Protein ID | BMDBP00928 | ||
| Secondary Accession Numbers |
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| Name | Tryptophan--tRNA ligase, cytoplasmic | ||
| Synonyms | Not Available | ||
| Gene Name | WARS1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Translation, ribosomal structure and biogenesis | ||
| Specific Function | T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). | ||
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 21 | ||
| Locus | Not Available | ||
| SNPs | WARS1 | ||
| Gene Sequence |
>1428 bp ATGGCAGACATGTCCAATGGCGAGCAGGGCTGTGGGTCCCCCCTGGAGCTGTTCCACAGC ATCGCTGCTCAGGGGGAGCTCGTAAGGGACCTCAAAGCCAGAAACGCAGCCAAGGATGAA ATTGATTCTGCAGTGAAGATGTTGTTGTCCTTAAAAACGAGCTACAAAGCTGCCACAGGG GAGGATTACAAGGTGGACTGTCCTCCAGGGGACCCGGCGCCTGAGAGTGGTGAGGGCCTG GATGCCACCGAAGCAGACGAGGACTTTGTGGATCCCTGGACAGTGCAGACAAGCAGCGCC AAAGGCATTGACTACGACAAGCTCATTGTTCGATTTGGAAGCAGTAAAATTGACAAGGAG CTGGTAAACCGAATAGAGAGAGCCACGGGCCAGAGACCACACCGCTTCCTGCGCAGGGGA ATCTTCTTCTCACACAGAGACATGCATCAGATTCTGGATGCCTATGAAAACAAGAAGCCG TTCTATCTCTACACGGGCAGGGGCCCCTCTTCTGAAGCCATGCATGTGGGTCACCTCATC CCATTCATCTTCACCAAGTGGCTGCAGGATGTGTTCAACGTCCCCTTGGTCATCCAGATG ACTGATGACGAGAAGTACCTGTGGAAGGACCTGACCCTGGATCAGGCCTATGGCTACGCT GTGGAGAACGCCAAGGATATCACGTGCGGCTTTGACATCAACAAAACGTTCATCTTCTCT GACCTTGACTACATGGGGATGAGCCCTGGCTTCTACAAGAACGTGGTGAAGATCCAGAAG CACGTCACCTTCAACCAAGTGAAAGGCATTTTCGGCTTCACTGACAGCGACTGCATTGGG AAGATCAGTTTTCCTGCCATCCAGGCCGCTCCCTCCTTCAGCAACTCATTCCCTCAGATC TTCCGAGACCGGACGGACGTCCAGTGCCTCATCCCGTGCGCCATCGACCAGGACCCGTAC TTCAGGATGACCAGGGACGTGGCCCCCAGGATCGGCTACCCCAAGCCAGCCCTCTTGCAC TCGACCTTCTTCCCTGCCCTGCAGGGGGCCCAGACCAAGATGAGTGCCAGTGACCCCAAC TCTTCCATCTTCCTCACGGACACGGCCAAGCAGATCAAGACCAAGGTCAACAAGCACGCC TTCTCCGGAGGCAGGGACACCGTTGAGGAGCACCGGCAGTTTGGGGGCAACTGTGACGTG GACGTGTCCTTCATGTACCTGACCTTCTTCCTGGAGGATGATGACAAGCTGGAGCAGATC AGGAGGGACTACACGAGCGGGGCCATGCTCACCGGCGAGCTCAAGAAGGAGCTCATCGAA GTCCTGCAGCCCTTGATTGCCGAGCACCAGGCCCGGCGCAAGGAGGTCACCGACGAGATC GTGAAAGAATTCATGACCCCCCGGAAGCTGTCCTACGACTTTCAGTAA |
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| Protein Properties | |||
| Number of Residues | 476 | ||
| Molecular Weight | 53812.0 | ||
| Theoretical pI | 5.51 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Tryptophanyl-tRNA synthetase, cytoplasmic MADMSNGEQGCGSPLELFHSIAAQGELVRDLKARNAAKDEIDSAVKMLLSLKTSYKAATG EDYKVDCPPGDPAPESGEGLDATEADEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKE LVNRIERATGQRPHRFLRRGIFFSHRDMHQILDAYENKKPFYLYTGRGPSSEAMHVGHLI PFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYGYAVENAKDIIACGFDINKTFIF SDLDYMGMSPGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQ IFRDRTDVQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDP NSSIFLTDTAKQIKTKVNKHAFSGGRDTVEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQ IRRDYTSGAMLTGELKKELIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSYDFQ |
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| External Links | |||
| GenBank ID Protein | CAA37872.1 | ||
| UniProtKB/Swiss-Prot ID | P17248 | ||
| UniProtKB/Swiss-Prot Entry Name | SYWC_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | X53918 | ||
| GeneCard ID | WARS1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||