| Identification |
|---|
| BMDB Protein ID
| BMDBP00940 |
| Secondary Accession Numbers
| None |
| Name
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| Synonyms
|
Not Available
|
| Gene Name
| FNTA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 27 |
| Locus
| Not Available |
| SNPs
| FNTA |
| Gene Sequence
|
>990 bp
ATGGACGACGGGTTCCTGAGCCTGGACTCTCCCACCTATGTCCTGTACAGGGACAGGCCA
GAATGGGCTGATATAGATCCAGTGCCGCAGAATGATGGCCCCAATCCAGTGGTCCAGATC
ATTTATAGTGAGAAATTTCAGGACGTCTATGATTATTTCCGGGCTGTCCTGCAGCGCGAC
GAGAGAAGTGAGCGGGCTTTTAAATTAACCAGAGATGCTATTGAGTTAAATGCAGCCAAC
TACACAGTGTGGCATTTCCGAAGAGTTCTCTTAAAGTCACTTCAGAAGGATCTACATGAG
GAAATGAACTACATCTCGGCAATAATTGAGGAGCAGCCCAAAAACTATCAAGTTTGGCAT
CATAGGCGAGTGCTGGTGGAATGGCTGAGAGACCCATCACAGGAGCTTGAGTTTATTGCG
GATATTCTTACTCAGGATGCAAAGAATTACCATGCCTGGCAGCACCGACAGTGGGTTATT
CAGGAATTTAAACTTTGGGATAATGAGCTGCAGTATGTAGACCAACTTCTCAAAGAGGAT
GTGAGAAATAACTCTGTCTGGAACCAAAGATATTTCGTAATTTCTAACACTACGGGCTAC
AATGATCGTGCTATATTGGAGAGAGAAGTCCAGTACACTCTGGAAATGATCAAACTAGTC
CCACATAATGAAAGTGCGTGGAATTATTTGAAAGGGATTTTGCAGGATCGTGGTCTTTCC
AAATATCCCAATCTGTTAAATCAATTACTTGACTTACAACCAAGTCACAGCTCTCCCTAC
CTAATTGCCTTTCTTGTGGATATCTATGAAGACATGCTAGAAAACCAATGTGACAACAAG
GAGGACATTCTTAATAAAGCGTTAGAGTTATGTGAAATCTTAGCTAAAGAAAAGGACACT
ATAAGAAAGGAATATTGGAGATATATTGGAAGATCCCTTCAAAGCAAACACAGCACAGAA
AGTGACCCACCTACAAACGTACAGCAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 375 |
| Molecular Weight
| 43845.0 |
| Theoretical pI
| 4.61 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 28-46
- 58-79
- 515-533
- 545-564
|
| Protein Sequence
|
>Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
MAAADGVGEAAQGGDPGQPEPPPPPQPHPPPPPPQPPQEEAAAASPIDDGFLSLDSPTYV
LYRDRPEWADIDPVPQNDGPNPVVQIIYSEKFQDVYDYFRAVLQRDERSERAFKLTRDAI
ELNAANYTVWHFRRVLLKSLQKDLHEEMNYISAIIEEQPKNYQVWHHRRVLVEWLRDPSQ
ELEFIADILTQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVI
SNTTGYNDRAILEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQP
SHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQ
SKHSTESDPPTNVQQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI12663.1 |
| UniProtKB/Swiss-Prot ID
| P29702 |
| UniProtKB/Swiss-Prot Entry Name
| FNTA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC112662 |
| GeneCard ID
| FNTA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
