Showing Protein Gamma-aminobutyric acid receptor-associated protein-like 2 (BMDBP00950)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00950 |
| Secondary Accession Numbers | None |
| Name | Gamma-aminobutyric acid receptor-associated protein-like 2 |
| Synonyms | Not Available |
| Gene Name | GABARAPL2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATPase binding |
| Specific Function | Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | GABARAPL2 |
| Gene Sequence |
>354 bp ATGAAGTGGATGTTCAAGGAGGACCACTCGCTGGAACACAGATGCGTGGAATCTGCGAAG ATCAGAGCGAAATACCCCGACCGGGTTCCGGTGATTGTGGAAAAGGTCTCAGGCTCTCAG ATTGTTGACATTGACAAACGGAAGTATCTGGTTCCATCCGACATCACTGTGGCTCAGTTC ATGTGGATCATCAGGAAAAGGATCCAGCTTCCTTCTGAAAAGGCGATCTTCCTGTTTGTG GATAAGACAGTCCCTCAGTCCAGCCTAACTATGGGACAGCTTTACGAGAAGGAAAAAGAT GAAGATGGATTCTTGTACGTGGCCTACAGTGGCGAGAACACTTTCGGCTTCTGA |
| Protein Properties | |
| Number of Residues | 117 |
| Molecular Weight | 13667.0 |
| Theoretical pI | 8.43 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Gamma-aminobutyric acid receptor-associated protein-like 2 MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQF MWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF |
| External Links | |
| GenBank ID Protein | AAD20720.1 |
| UniProtKB/Swiss-Prot ID | P60519 |
| UniProtKB/Swiss-Prot Entry Name | GBRL2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AF020262 |
| GeneCard ID | GABARAPL2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |