Identification
BMDB Protein ID BMDBP00954
Secondary Accession Numbers None
Name Alpha-aminoadipic semialdehyde dehydrogenase
Synonyms Not Available
Gene Name ALDH7A1
Protein Type Enzyme
Biological Properties
General Function Energy production and conversion
Specific Function Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity).
Pathways
  • Amine and polyamine biosynthesis
  • Betaine biosynthesis via choline pathway
  • Betaine from betaine aldehyde: step 1/1
  • Betaine Metabolism
  • Lysine Degradation
Reactions
Betaine aldehyde + NAD + Water → Betaine + NADH details
Allysine + NAD + Water → Aminoadipic acid + NADH details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 7
Locus Not Available
SNPs ALDH7A1
Gene Sequence
>1536 bp
ATGTCCACTCTGCTCATCAATCAACCCCAGTATGCTTGGCTGAAGGAGCTGGGGCTCCGC
GAGGAAAACGACGGCGTATATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATCACCACC
TACTGTCCTGCTAACAATGAGCCCATTGCAAGAGTCAGACAGGCCAGCATGGCTGACTAT
GAAGAAACTGTAGAGAAAGCACGAGAAGCATGGAGCATCTGGGCAGATGTTCCTGCTCCA
AAGCGAGGAGAAGTAGTGAGACAGATTGGTGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAGATCTTGGTGGAAGGTGTGGGAGAAGTTCAG
GAATACGTGGATGTTTGTGATTATGCTGTTGGCTTATCTCGGATGATTGGGGGACCCATC
CTGCCTTCTGAAAGACCTGGCCATGCTCTCATTGAACAGTGGAATCCTGTAGGCCTGGTT
GGAATCATCACTGCTTTCAACTTCCCTGTGGCCGTGTATGGCTGGAACAACGCCATTGCC
ATGATCTGTGGGAATGCTTGTCTTTGGAAAGGAGCTCCTACAACTTCCCTCATCAGTGTA
GCTGTCACAAAAATAATAGCCAAAGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATCGGCACAGCAATGGCCAAGGATGAGCGAGTGGAC
CTGTTGTCCTTCACCGGGAGCACTCAAGTGGGAAAACAGGTGGCCCTTATGGTACAGGAG
AGGTTTGGGAGAAGTTTATTAGAACTTGGAGGAAACAATGCCATTATAGCTTTTGAGGAC
GCGGACCTCAGCTTAGTCGTCCCCTCAGCTCTCTTTGCAGCCGTGGGCACAGCCGGCCAG
AGGTGCACCACCGCGAGGCGCCTGTTCTTACATGAAAGCATCCATGATGAAGTTGTCAAT
AGACTTAAAAAGGCCTACGCACAGATCCGTGTTGGGAACCCTTGGGACTCTAATGTTCTG
TATGGGCCACTCCACACCAAACAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACCGTTGTCTATGGTGGCAAGGTTATGGATCGCCCTGGAAATTAC
GTAGAACCGACAATCGTGACAGGTCTTGACCATGACGCATCCATTGTACACACAGAGACT
TTTGCCCCGATTCTTTATGTCTTTAAATTCAAGAATGAAGATGAGGTCTTTGCATGGAAC
AATGAAGTCAAACAGGGACTTTCAAGTAGCATCTTTACCAAGGATATGGGCAGAATCTTT
CGCTGGCTTGGACCAAAAGGATCAGACTGTGGCATTGTAAACGTCAACATTCCGACAAGT
GGGGCTGAGATTGGAGGTGCATTTGGAGGAGAGAAGCACACTGGCGGTGGCAGGGAGTCA
GGCAGTGATGCCTGGAAGCAGTACATGAGAAGATCTACTTGTACCATCAACTACAGTAAG
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA
Protein Properties
Number of Residues 539
Molecular Weight 58582.0
Theoretical pI 5.75
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Alpha-aminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENDGVYNGSWGGRGEVITTYCPANNEPIARVRQASMADY
EETVEKAREAWSIWADVPAPKRGEVVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDVCDYAVGLSRMIGGPILPSERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNACLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVD
LLSFTGSTQVGKQVALMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFLHESIHDEVVNRLKKAYAQIRVGNPWDSNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLDHDASIVHTETFAPILYVFKFKNEDEVFAWN
NEVKQGLSSSIFTKDMGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
GenBank ID Protein AAI05407.1
UniProtKB/Swiss-Prot ID Q2KJC9
UniProtKB/Swiss-Prot Entry Name AL7A1_BOVIN
PDB IDs Not Available
GenBank Gene ID BC105406
GeneCard ID ALDH7A1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available