Showing Protein 3-hydroxyacyl-CoA dehydrogenase type-2 (BMDBP00961)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00961 | ||
| Secondary Accession Numbers |
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| Name | 3-hydroxyacyl-CoA dehydrogenase type-2 | ||
| Synonyms | Not Available | ||
| Gene Name | HSD17B10 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Lipid transport and metabolism | ||
| Specific Function | Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structural and functional integrity of mitochondria. | ||
| Pathways | Not Available | ||
| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | X | ||
| Locus | Not Available | ||
| SNPs | HSD17B10 | ||
| Gene Sequence |
>786 bp ATGGCAGCTGCTTGTCGGAGCGTGAAGGGTCTGGTTGCCTTAATAACCGGCGGAGCCTCA GGCCTAGGCTTGGCCACAGCGGAGCGACTGGTGGGGCAGGGGGCCACTGCTGTACTTTTG GACCTGCCCAACTCAGATGGGGAGACCCAGGCCAAGAAGTTAGGGAAGAGCTGCGCCTTT GCCCCAGCCGACGTGACCTCAGAGAAGGATGTGCAAGCAGCCCTGACTCTAGCAAGAGAA AAGTTTGGCCGTGTGGATGTGGCAGTCAACTGTGCAGGCATTGCAGTGGCCAGCAAGACA TATAACTTAAAGAAAAGCCAGGCCCATACCTTGGAGGACTTTCAGCGAGTTATCAATGTG AATCTCATAGGCACCTTCAATGTGATCCGCCTGGTGGCTGGTGAGATGGGCCAGAACGAA CCAGACCAGGGAGGCCAACGTGGGGTCATCATCAATACAGCCAGCGTAGCTGCCTTTGAG GGCCAGGTTGGACAAGCTGCATACTCTGCTTCCAAGGGGGGCATAGTGGGCATGACATTG CCCATTGCTCGGGATCTGGCTCCCATGGGTATCCGGGTGATGACCATTGCTCCAGGCCTA TTTGGCACCCCGCTGTTGACCACCCTCCCAGATAAAGTGCGCAACTTCCTGGCCAGCCAG GTGCCCTTCCCCAGCCGACTTGGTGACCCTGCCGAGTATGCTCATCTGGTACAGGCCATC ATCGAGAACTCATTCCTCAATGGAGAAGTCATCCGGCTGGATGGGGCCATCCGCATGCAG CCTTGA |
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| Protein Properties | |||
| Number of Residues | 261 | ||
| Molecular Weight | 27140.0 | ||
| Theoretical pI | 8.48 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>3-hydroxyacyl-CoA dehydrogenase type-2 MAAACRSVKGLVALITGGASGLGLATAERLVGQGATAVLLDLPNSDGETQAKKLGKSCAF APADVTSEKDVQAALTLAREKFGRVDVAVNCAGIAVASKTYNLKKSQAHTLEDFQRVINV NLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL PIARDLAPMGIRVMTIAPGLFGTPLLTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQAI IENSFLNGEVIRLDGAIRMQP |
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| External Links | |||
| GenBank ID Protein | BAA19510.1 | ||
| UniProtKB/Swiss-Prot ID | O02691 | ||
| UniProtKB/Swiss-Prot Entry Name | HCD2_BOVIN | ||
| PDB IDs | |||
| GenBank Gene ID | AB002156 | ||
| GeneCard ID | HSD17B10 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||