Showing Protein Ubiquitin-conjugating enzyme E2 L3 (BMDBP00969)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00969 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 L3 |
| Synonyms | Not Available |
| Gene Name | UBE2L3 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 17 |
| Locus | Not Available |
| SNPs | UBE2L3 |
| Gene Sequence |
>465 bp ATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAGTGTGGGATGAAA AACTTCCGTAACATCCAGGTCGATGAAGCTAATTTGCTGACTTGGCAAGGGCTCATTGTT CCCGACAACCCTCCCTATGATAAGGGGGCCTTCAGAATCGAAATCAACTTTCCAGCAGAG TACCCCTTCAAACCACCGAAGATCACGTTCAAAACGAAGATCTACCACCCGAACATCGAC GAGAAGGGGCAGGTGTGTCTGCCTGTAATTAGTGCTGAAAACTGGAAGCCAGCAACCAAA ACCGACCAAGTCATCCAGTCCCTCATAGCACTGGTGAACGACCCCCAGCCGGAGCACCCG CTCCGGGCTGACCTAGCCGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCT GAAGAATTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAA |
| Protein Properties | |
| Number of Residues | 154 |
| Molecular Weight | 17862.0 |
| Theoretical pI | 8.79 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 L3 MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD |
| External Links | |
| GenBank ID Protein | AAI05165.1 |
| UniProtKB/Swiss-Prot ID | Q3MHP1 |
| UniProtKB/Swiss-Prot Entry Name | UB2L3_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC105164 |
| GeneCard ID | UBE2L3 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |