Showing Protein NEDD8-conjugating enzyme Ubc12 (BMDBP00972)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00972 |
| Secondary Accession Numbers | None |
| Name | NEDD8-conjugating enzyme Ubc12 |
| Synonyms | Not Available |
| Gene Name | UBE2M |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | UBE2M |
| Gene Sequence |
>552 bp ATGATCAAGCTGTTCTCGCTGAAGCAGCAGAAGAAGGAGGAGGAGTCGGCGGGCGGCACC AAGGGCAGCAGCAAGAAGGCGTCGGCGGCGCAGCTGCGGATCCAGAAGGACATAAACGAG CTGAATCTGCCCAAGACGTGTGACATCAGTTTCTCAGATCCAGACGACCTCCTCAACTTC AAGCTGGTTATCTGTCCTGATGAGGGCTTCTACAAGAGCGGGAAGTTTGTGTTCAGTTTT AAGGTGGGCCAGGGTTACCCGCATGACCCCCCCAAGGTGAAGTGTGAGACGATGGTTTAT CACCCCAACATTGACCTCGAGGGCAACGTCTGCCTCAACATCCTCAGAGAGGACTGGAAG CCAGTCCTTACGATAAACTCCATAATTTATGGCTTGCAGTATCTCTTCTTGGAGCCCAAC CCTGAAGACCCACTGAACAAGGAAGCCGCCGAGGTCCTGCAGAACAACCGGAGGCTGTTT GAGCAGAATGTCCAGCGCTCCATGCGGGGTGGCTATATCGGCTCCACTTACTTCGAGCGC TGCCTGAAATAG |
| Protein Properties | |
| Number of Residues | 183 |
| Molecular Weight | 20900.0 |
| Theoretical pI | 7.84 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>NEDD8-conjugating enzyme Ubc12 MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER CLK |
| External Links | |
| GenBank ID Protein | AAI33502.1 |
| UniProtKB/Swiss-Prot ID | A3KN22 |
| UniProtKB/Swiss-Prot Entry Name | UBC12_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC133501 |
| GeneCard ID | UBE2M |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |