Showing Protein Ubiquitin-conjugating enzyme E2 C (BMDBP00975)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00975 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 C |
| Synonyms | Not Available |
| Gene Name | UBE2C |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 13 |
| Locus | Not Available |
| SNPs | UBE2C |
| Gene Sequence |
>540 bp ATGGCTTCCCAGAACCGCGACCCAGTCGCCGCCAGCGTCGCCGCCGCCCGTAAAGGAGCC GAGCCCAGCGGGGGTGCTGCCCGGGGCCCTGTGGGCAAGAGGCTACAACAGGAGCTGATG ACTCTCATGATGTCTGGCGATAAAGGAATTTCTGCCTTCCCTGAATCCGACAACCTCTTC AAATGGGTGGGGACCATCCATGGAGCCGCTGGCACAGTATATGAAGACCTGAGGTATAAA CTGTCCCTGGAGTTCCCCAGTGGCTACCCTTACAACGCGCCCACGGTGAAGTTCCTCACA CCCTGCTACCATCCCAATGTGGACACCCAGGGTAACATCTGTCTGGACATCCTGAAAGAC AAGTGGTCCGCCCTGTATGACGTCAGGACCATCCTGCTCTCCATCCAGAGTCTGCTCGGA GAGCCCAACATTGATAGCCCTTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA GCCTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCTCCAGCCAAGACCCCTGA |
| Protein Properties | |
| Number of Residues | 179 |
| Molecular Weight | 19608.0 |
| Theoretical pI | 7.5 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 C MASQNRDPVAASVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKD KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVSSQDP |
| External Links | |
| GenBank ID Protein | AAI08196.1 |
| UniProtKB/Swiss-Prot ID | Q32PA5 |
| UniProtKB/Swiss-Prot Entry Name | UBE2C_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC108195 |
| GeneCard ID | UBE2C |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |