Showing Protein Ubiquitin-conjugating enzyme E2 B (BMDBP00977)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00977 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 B |
| Synonyms | Not Available |
| Gene Name | UBE2B |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | UBE2B |
| Gene Sequence |
>459 bp ATGTCGACCCCGGCCCGGAGGAGGCTTATGCGGGATTTCAAGCGATTGCAAGAGGACCCA CCTGTGGGTGTCAGTGGCGCACCATCTGAAAACAACATCATGCAGTGGAATGCAGTTATA TTTGGACCAGAAGGGACACCCTTTGAAGATGGAACTTTTAAACTAGTAATAGAATTTTCT GAAGAATATCCAAATAAGCCGCCAACTGTTAGGTTTTTATCCAAAATGTTTCATCCAAAT GTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATAGATGGAGTCCAACATAC GATGTATCTTCTATCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCAAATAGT CCAGCCAATAGTCAGGCAGCACAGCTTTATCAGGAAAACAAACGAGAATATGAGAAAAGA GTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAA |
| Protein Properties | |
| Number of Residues | 152 |
| Molecular Weight | 17312.0 |
| Theoretical pI | 4.64 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 B MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFS EEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNS PANSQAAQLYQENKREYEKRVSAIVEQSWNDS |
| External Links | |
| GenBank ID Protein | AAI08203.1 |
| UniProtKB/Swiss-Prot ID | Q32P99 |
| UniProtKB/Swiss-Prot Entry Name | UBE2B_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC108202 |
| GeneCard ID | UBE2B |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |