Showing Protein Ubiquitin-conjugating enzyme E2 D2 (BMDBP00978)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00978 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 D2 |
| Synonyms | Not Available |
| Gene Name | UBE2D2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | UBE2D2 |
| Gene Sequence |
>444 bp ATGGCTCTGAAGAGAATCCATAAGGAATTGAATGACCTGGCACGGGACCCCCCAGCACAG TGTTCAGCAGGTCCCGTTGGAGATGATATGTTCCATTGGCAAGCTACAATAATGGGGCCA AATGACAGTCCCTATCAGGGTGGAGTATTTTTCTTGACAATTCATTTCCCAACAGATTAC CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT AATGGCAGCATTTGTCTTGATATTCTACGGTCACAGTGGTCTCCAGCACTAACTATTTCA AAAGTACTTTTGTCCATCTGTTCTCTGTTGTGTGATCCCAATCCAGATGATCCTTTAGTG CCTGAGATTGCTCGGATCTACAAAACAGATAGAGAAAAGTACAACAGAATAGCTCGGGAA TGGACTCAGAAGTATGCGATGTAA |
| Protein Properties | |
| Number of Residues | 147 |
| Molecular Weight | 16735.0 |
| Theoretical pI | 7.96 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 D2 MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV PEIARIYKTDREKYNRIAREWTQKYAM |
| External Links | |
| GenBank ID Protein | AAI14655.1 |
| UniProtKB/Swiss-Prot ID | Q1RMX2 |
| UniProtKB/Swiss-Prot Entry Name | UB2D2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC114654 |
| GeneCard ID | UBE2D2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |