Showing Protein Ubiquitin-conjugating enzyme E2 D1 (BMDBP00982)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00982 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 D1 |
| Synonyms | Not Available |
| Gene Name | UBE2D1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 26 |
| Locus | Not Available |
| SNPs | UBE2D1 |
| Gene Sequence |
>444 bp ATGGCGCTGAAGCGGATTCAGAAAGAGTTAAGTGATCTACAACGTGACCCACCTGCTCAC TGTTCGGCTGGACCTGTGGGAGATGACTTGTTCCACTGGCAAGCAACTATTATGGGGCCT CCTGATAGCGCATATCAAGGTGGAGTCTTCTTTCTCACTGTACATTTTCCGACAGACTAT CCTTTTAAACCACCAAAGATTGCTTTCACAACAAAAATTTACCATCCAAACATAAACAGT AATGGAAGTATTTGTCTTGATATCCTGAGGTCACAATGGTCACCAGCTCTGACTGTGTCA AAAGTTTTATTGTCCATATGTTCTCTGCTTTGTGACCCTAATCCAGATGATCCCTTAGTA CCAGATATTGCTCAAATCTATAAATCAGACAAAGAAAAATACAACAGACACGCAAGAGAA TGGACTCAGAAATATGCAATGTAA |
| Protein Properties | |
| Number of Residues | 147 |
| Molecular Weight | 16602.0 |
| Theoretical pI | 7.5 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 D1 MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDY PFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV PDIAQIYKSDKEKYNRHAREWTQKYAM |
| External Links | |
| GenBank ID Protein | AAI11176.1 |
| UniProtKB/Swiss-Prot ID | Q2TA10 |
| UniProtKB/Swiss-Prot Entry Name | UB2D1_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC111175 |
| GeneCard ID | UBE2D1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |