Showing Protein Ubiquitin-conjugating enzyme E2 T (BMDBP00983)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00983 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 T |
| Synonyms | Not Available |
| Gene Name | UBE2T |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | Not Available |
| Locus | Not Available |
| SNPs | UBE2T |
| Gene Sequence |
>588 bp ATGCAGAGAACATCGCGTCTGAAGCGAGAGCTGAGCCTGCTGGCCGCGGAGCCGCCCCCG GGCATCACGTGCTGGCAGGATGGGGATCGGATGGAAGACCTGCGAGCGCAGATTCTAGGT GGAGCCAACACACCTTATGAAAAAGGTGTTTTCAAGCTGGAAGTTCACATTCCAGAGAGG TACCCATTTGAACCTCCTCAGATCCGATTTCTGACTCCCATCTATCACCCCAACATCGAC TCTGCGGGACGGATTTGTCTAGATGTTCTCAAGTTGCCACCAAAAGGTGCCTGGAGACCA TCCCTCAACATCGCAACCCTGCTGACTTGCATTCAGCAGCTCATGGCCGAGCCCAACCCG GACGACCCGCTCATGGCTGACATCTCCTCAGAGTTTAAATACAACAAGCCAGTCTTCTTC AAGAACGCCAGGCAGTGGACAGAGAAGCACGCACGGCAGAAGACAGACGAGGAAGGGATG CCTGGCAGCCTCCCCGAGGTGGGCGGCTCAGAGGGACCCAGCGCCGCACAGAAGAGGAAA GCTGGGCAGCTGAGCAGCGGTGGAAAGAGGTTTTGCCCTGACGTTTAG |
| Protein Properties | |
| Number of Residues | 195 |
| Molecular Weight | 21765.0 |
| Theoretical pI | 8.32 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 T MQRTSRLKRELSLLAAEPPPGITCWQDGDRMEDLRAQILGGANTPYEKGVFKLEVHIPER YPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATLLTCIQQLMAEPNP DDPLMADISSEFKYNKPVFFKNARQWTEKHARQKTDEEGMPGSLPEVGGSEGPSAAQKRK AGQLSSGGKRFCPDV |
| External Links | |
| GenBank ID Protein | AAI09638.1 |
| UniProtKB/Swiss-Prot ID | Q32LD2 |
| UniProtKB/Swiss-Prot Entry Name | UBE2T_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | DAAA02043707 |
| GeneCard ID | UBE2T |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |