Showing Protein Ubiquitin-conjugating enzyme E2 K (BMDBP00984)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00984 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 K |
| Synonyms | Not Available |
| Gene Name | UBE2K |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53 (By similarity). Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 6 |
| Locus | Not Available |
| SNPs | UBE2K |
| Gene Sequence |
>603 bp ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAG GAGACGACGAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGA GGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATATCAACTAGAGATT AAAATACCAGAAACATATCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGG CATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGG GCAGCAGCAATGACTCTGCGCACGGTATTGTTGTCATTACAAGCTCTGCTGGCAGCTGCA GAACCGGATGATCCACAAGATGCAGTAGTAGCAAATCAGTACAAACAAAATCCTGAAATG TTCAAACAGACAGCTCGACTTTGGGCACATGTGTATGCTGGAGCACCAGTTTCTAGTCCA GAGTACACCAAAAAAATAGAAAACCTATGTGCTATGGGCTTTGATAGGAATGCGGTAATA GTGGCCTTGTCTTCAAAATCATGGGATGTAGAGACTGCAACAGAATTGCTTCTGAGTAAC TGA |
| Protein Properties | |
| Number of Residues | 200 |
| Molecular Weight | 22407.0 |
| Theoretical pI | 5.1 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 K MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI VALSSKSWDVETATELLLSN |
| External Links | |
| GenBank ID Protein | AAB19536.1 |
| UniProtKB/Swiss-Prot ID | P61085 |
| UniProtKB/Swiss-Prot Entry Name | UBE2K_BOVIN |
| PDB IDs | |
| GenBank Gene ID | S51016 |
| GeneCard ID | UBE2K |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |