Showing Protein Ubiquitin-conjugating enzyme E2 S (BMDBP00985)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00985 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin-conjugating enzyme E2 S |
| Synonyms | Not Available |
| Gene Name | UBE2S |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | UBE2S |
| Gene Sequence |
>672 bp ATGAACTCCAACGTGGAGAACCTGCCCCCCCACATCATCCGCCTGGTGTACAAGGAGGTG ACGACGCTGACCGCTGACCCACCTGATGGCATCAAGGTCTTTCCCAACGAGGAAGACCTT ACCGACCTGCAGGTCACCATTGAGGGCCCTGAGGGGACCCCGTATGCCGGAGGCCTCTTC CGCATGAAACTCCTGCTGGGGAAGGACTTTCCGGCCTCCCCACCCAAGGGCTACTTCCTG ACGAAGATCTTCCACCCGAATGTGGGCGCCAATGGCGAGATCTGCGTCAATGTGCTCAAG AGGGACTGGACCGCTGAGCTGGGCATCCGGCACGTGCTTCTGACCATCAAGTGCCTGCTG ATCCACCCCAACCCCGAGTCGGCCCTCAACGAGGAGGCGGGCCGCCTGCTGCTGGAGAAC TACGAGGAGTACGCAGCCCGCGCGCGCCTGCTCACTGAGATCCACGGCGGCGCCGGCGGG CCCAGCGGTGGGAGGCCCGAGCCCGGCCGGGCCACTGCCAGTGGGGCGGCGGCCTCCACT GCTGACCCCACAGCCACTGGGGGCCCAGCAGGGGCTGAGGGGCCCATGGCCAAGAAGCAC GCGGGCGAGCGCGACAAGAAGCTGGCAGCCAAGAAAAAGACGGACAAGAAGCGGGCACTG CGGCGCCTGTAG |
| Protein Properties | |
| Number of Residues | 223 |
| Molecular Weight | 23896.0 |
| Theoretical pI | 9.05 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ubiquitin-conjugating enzyme E2 S MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLF RMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLL IHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGGRPEPGRATASGAAAST ADPTATGGPAGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL |
| External Links | |
| GenBank ID Protein | AAI14839.1 |
| UniProtKB/Swiss-Prot ID | Q1RML1 |
| UniProtKB/Swiss-Prot Entry Name | UBE2S_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC114838 |
| GeneCard ID | UBE2S |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |