Showing Protein Aldo-keto reductase family 1 member A1 (BMDBP00987)
Identification | |
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BMDB Protein ID | BMDBP00987 |
Secondary Accession Numbers | None |
Name | Aldo-keto reductase family 1 member A1 |
Synonyms | Not Available |
Gene Name | AKR1A1 |
Protein Type | Enzyme |
Biological Properties | |
General Function | Involved in alcohol dehydrogenase (NADP+) activity |
Specific Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (By similarity). |
Pathways | Not Available |
Reactions | Not Available |
GO Classification | Not Available |
Cellular Location | Not Available |
Gene Properties | |
Chromosome Location | 3 |
Locus | Not Available |
SNPs | AKR1A1 |
Gene Sequence |
>978 bp ATGGCGGCTTCCTGTATCCTCCTACACACTGGGCAGAAGATGCCCCTGATTGGACTGGGC ACCTGGAAGAGCGACCCTGGCCAGGTTAAAGCAGCTATTAAGTATGCCCTGAGTGTAGGC TACCGTCACATTGACTGTGCTGCTATCTATGGCAATGAGACTGAAATCGGGGAAGCCCTG AAGGAGAATGTGGGACCTGGCAAGTTGGTGCCTCGGGAGGAGCTCTTTGTGACTTCCAAG CTGTGGAACACAAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACACTTGCT GACCTGCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTACGCCTTTGAGCGG GGAGACAGCCCCTTCCCTAAGAATGCTGATGGGACTATACGCTATGACTCCACCCACTAC AAGGAGACCTGGAGGGCTCTGGAGGCACTCGTGGCTAAGGGGCTGGTGCGGGCTCTGGGC CTGTCCAACTTCAACAGTCGGCAGATTGACGATGTGCTCAGCGTGGCCTCTGTACGCCCA GCTGTCCTGCAGGTGGAATGCCACCCATACCTGGCTCAGAATGAGCTGATTGCCCACTGC CAAGCACGAAACCTGGAGGTGACTGCTTATAGCCCTCTGGGCTCCTCTGATCGTGCGTGG CGTGATCCTGAGGAGCCTGTCCTGCTTAAGGAGCCAGTGGTCCTGGCACTGGCAGAAAAG CATGGTCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGAGCTGC ATCCCCAAGAGTGTCACGCCTTCCCGTATCCTTGAGAACATCCAGGTGTTTGACTTCACC TTTAGCCCAGAGGAGATGAAGCAGCTGGATGCCCTGAATAAAAATTTGCGATTCATTGTG CCCATGCTTACGGTGGATGGGAAGAGGGTCCCAAGAGATGCAGGGCACCCTCTGTACCCC TTCAATGACCCATATTGA |
Protein Properties | |
Number of Residues | 325 |
Molecular Weight | 36617.0 |
Theoretical pI | 7.31 |
Pfam Domain Function | Not Available |
Signals |
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Transmembrane Regions | Not Available |
Protein Sequence |
>Alcohol dehydrogenase [NADP+] MAASCILLHTGQKMPLIGLGTWKSDPGQVKAAIKYALSVGYRHIDCAAIYGNETEIGEAL KENVGPGKLVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER GDSPFPKNADGTIRYDSTHYKETWRALEALVAKGLVRALGLSNFNSRQIDDVLSVASVRP AVLQVECHPYLAQNELIAHCQARNLEVTAYSPLGSSDRAWRDPEEPVLLKEPVVLALAEK HGRSPAQILLRWQVQRKVSCIPKSVTPSRILENIQVFDFTFSPEEMKQLDALNKNLRFIV PMLTVDGKRVPRDAGHPLYPFNDPY |
External Links | |
GenBank ID Protein | AAI02167.1 |
UniProtKB/Swiss-Prot ID | Q3ZCJ2 |
UniProtKB/Swiss-Prot Entry Name | AK1A1_BOVIN |
PDB IDs | |
GenBank Gene ID | BC102166 |
GeneCard ID | AKR1A1 |
GenAtlas ID | Not Available |
HGNC ID | Not Available |
References | |
General References | Not Available |