Identification
BMDB Protein ID BMDBP00987
Secondary Accession Numbers None
Name Aldo-keto reductase family 1 member A1
Synonyms Not Available
Gene Name AKR1A1
Protein Type Enzyme
Biological Properties
General Function Involved in alcohol dehydrogenase (NADP+) activity
Specific Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 3
Locus Not Available
SNPs AKR1A1
Gene Sequence
>978 bp
ATGGCGGCTTCCTGTATCCTCCTACACACTGGGCAGAAGATGCCCCTGATTGGACTGGGC
ACCTGGAAGAGCGACCCTGGCCAGGTTAAAGCAGCTATTAAGTATGCCCTGAGTGTAGGC
TACCGTCACATTGACTGTGCTGCTATCTATGGCAATGAGACTGAAATCGGGGAAGCCCTG
AAGGAGAATGTGGGACCTGGCAAGTTGGTGCCTCGGGAGGAGCTCTTTGTGACTTCCAAG
CTGTGGAACACAAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACACTTGCT
GACCTGCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTACGCCTTTGAGCGG
GGAGACAGCCCCTTCCCTAAGAATGCTGATGGGACTATACGCTATGACTCCACCCACTAC
AAGGAGACCTGGAGGGCTCTGGAGGCACTCGTGGCTAAGGGGCTGGTGCGGGCTCTGGGC
CTGTCCAACTTCAACAGTCGGCAGATTGACGATGTGCTCAGCGTGGCCTCTGTACGCCCA
GCTGTCCTGCAGGTGGAATGCCACCCATACCTGGCTCAGAATGAGCTGATTGCCCACTGC
CAAGCACGAAACCTGGAGGTGACTGCTTATAGCCCTCTGGGCTCCTCTGATCGTGCGTGG
CGTGATCCTGAGGAGCCTGTCCTGCTTAAGGAGCCAGTGGTCCTGGCACTGGCAGAAAAG
CATGGTCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGAGCTGC
ATCCCCAAGAGTGTCACGCCTTCCCGTATCCTTGAGAACATCCAGGTGTTTGACTTCACC
TTTAGCCCAGAGGAGATGAAGCAGCTGGATGCCCTGAATAAAAATTTGCGATTCATTGTG
CCCATGCTTACGGTGGATGGGAAGAGGGTCCCAAGAGATGCAGGGCACCCTCTGTACCCC
TTCAATGACCCATATTGA
Protein Properties
Number of Residues 325
Molecular Weight 36617.0
Theoretical pI 7.31
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Alcohol dehydrogenase [NADP+]
MAASCILLHTGQKMPLIGLGTWKSDPGQVKAAIKYALSVGYRHIDCAAIYGNETEIGEAL
KENVGPGKLVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDSPFPKNADGTIRYDSTHYKETWRALEALVAKGLVRALGLSNFNSRQIDDVLSVASVRP
AVLQVECHPYLAQNELIAHCQARNLEVTAYSPLGSSDRAWRDPEEPVLLKEPVVLALAEK
HGRSPAQILLRWQVQRKVSCIPKSVTPSRILENIQVFDFTFSPEEMKQLDALNKNLRFIV
PMLTVDGKRVPRDAGHPLYPFNDPY
GenBank ID Protein AAI02167.1
UniProtKB/Swiss-Prot ID Q3ZCJ2
UniProtKB/Swiss-Prot Entry Name AK1A1_BOVIN
PDB IDs
GenBank Gene ID BC102166
GeneCard ID AKR1A1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available