| Identification |
|---|
| BMDB Protein ID
| BMDBP00988 |
| Secondary Accession Numbers
| None |
| Name
| Aldehyde dehydrogenase X, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ALDH1B1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes. |
| Pathways
|
- Acetate from ethanol: step 2/2
- Alcohol metabolism
- Ethanol Degradation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ALDH1B1 |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 511 |
| Molecular Weight
| 56770.0 |
| Theoretical pI
| 6.62 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aldehyde dehydrogenase X, mitochondrial
PRLFALHHSATQYFSAAALPSPIPNPDIPDNQLFISNKWHDAVSKKTFPTVSPATGEVIG
HVAEGDWADVDLAAKAARAAFRLGSPWRWMDALKRGWLLNHLADLVERDCVYLASLESLD
NGKPFQESYVLDLDEVIKVYRYFAGWADKWHGKTIPMDGEHFCFTRHEPVGVCCQIIPWN
FPLVMQSWKLALALAMGNTVVTKVAEQTPFSALYLASLIKEVGLPPGLVNIVTGYGPTAG
AAIAHHMDIGKVAFTGSTKVGHLIQKAAGNSSLKRVTLELGGKSLSIVLADADMDHAVEQ
RQEALFFNMGQCCCPGSWTFIEESIYDEFLERTVEKAKQRRVGNPFDLDTQQGPQVDRER
FERILGYIQLGQKEGAKLLCGGEHFRQQCFFIKPTVFGGVQDDMRIAREEIFGPVQPLFK
FKKIEEVIERADNTRYGLAAAVFTQDLDKAMYFTQALQTGTVWVNTYNVVTCHTPLGGFK
EPGNGRELGEDGLKAYTEVKTVTIKVPQKNS
|
| External Links |
|---|
| GenBank ID Protein
| AAB26659.1 |
| UniProtKB/Swiss-Prot ID
| P52476 |
| UniProtKB/Swiss-Prot Entry Name
| AL1B1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AAFC03050684 |
| GeneCard ID
| ALDH1B1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
