Showing Protein Alcohol dehydrogenase class-3 (BMDBP00991)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 9 metabolites
Identification
BMDB Protein ID BMDBP00991
Secondary Accession Numbers None
Name Alcohol dehydrogenase class-3
Synonyms Not Available
Gene Name ADH5
Protein Type Enzyme
Biological Properties
General Function Energy production and conversion
Specific Function Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol.
Pathways
  • Ethanol Degradation
  • Retinol Metabolism
  • Tyrosine Metabolism
Reactions
3,4-Dihydroxymandelaldehyde + NAD → NADH + 3,4-Dihydroxyphenylglycol details
11-cis-Retinaldehyde + NAD → Retinal + NADH details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 6
Locus Not Available
SNPs ADH5
Gene Sequence 
>1125 bp
ATGGCGAACCAGGTTATCAAGTGCAAGGCTGCAGTTGCCTGGGAGGCTGGGAAGCCTCTT
TCTATAGAGGAGGTAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATTAAGATTATT
GCCACTGCAGTTTGCCACACTGACGCCTATACACTGAGTGGGGCTGATCCTGAAGGGAAT
TATCCAGTGATCTTGGGACACGAAGGTGCTGGAATTGTGGAGAGTGTTGGTGAAGGAGTT
ACTAAGCTGAAGGCAGGTGATACTGTCATCCCACTTTACATCCCCCAGTGTGGAGAATGC
AAGTTTTGTCTGAATCCTAAAACAAACCTTTGCCAGAAGATAAGAGTCACTCAAGGAAAA
GGATTAATGCCAGATGGCACTAGCAGATTTACTTGTAAAGGAAAGACAATTTTACATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGACATTTCTGTTGCTAAAATT
GATCCTTTAGCACCTTTGGATAAAGTTTGCCTTCTGGGTTGTGGCATTTCAACTGGCTAT
GGTGCTGCTTTGAATGCTGCCAAGGTGGAGCCTGGCTCTACTTGTGCTGTCTTTGGCCTG
GGAGGAGTTGGATTGGCAGTTATCATGGGCTGTAAGATGGCTGGTGCAGCCCGGATCATT
GGTGTGGACATCAATAAGGATAAATTCGCAAGAGCCAAGGAGTTCGGGGCCTCTGAGTGT
ATTAACCCCCAGGACTTCAGTAAACCGATCCAGGAAGTGCTCATTGAGATGACTGACGGG
GGAGTCGACTACTCCTTTGAGTGTATTGGTAATGTGAAAGTCATGAGAGCAGCGCTGGAG
GCCTGCCACAAAGGCTGGGGCATCAGCGTGGTAGTGGGAGTAGCTGCCTCTGGTGAAGAA
ATCGCCACTCGTCCGTTCCAGCTAGTCACGGGCCGCACGTGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAGTTTGTGACTCACAGTCTGCCTTTTGACCAAATTAATGAAGCCTTTGAT
CTGATGCATGCCGGAAAGAGCATCCGAACGGTTGTAAAGCTTTAA
Protein Properties
Number of Residues 374
Molecular Weight 39677.0
Theoretical pI 7.56
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 23-Mar
Protein Sequence 
>Alcohol dehydrogenase class-3
MANQVIKCKAAVAWEAGKPLSIEEVEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGN
YPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAALNAAKVEPGSTCAVFGLGGVGLAVIMGCKMAGAARIIGVDINKDKFARAKEFGASEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGISVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHSLPFDQINEAFD
LMHAGKSIRTVVKL
GenBank ID Protein AAI02927.1
UniProtKB/Swiss-Prot ID Q3ZC42
UniProtKB/Swiss-Prot Entry Name ADHX_BOVIN
PDB IDs
GenBank Gene ID BC102926
GeneCard ID ADH5
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available