Identification
BMDB Protein ID BMDBP00996
Secondary Accession Numbers None
Name Delta(14)-sterol reductase TM7SF2
Synonyms Not Available
Gene Name TM7SF2
Protein Type Enzyme
Biological Properties
General Function Involved in delta14-sterol reductase activity
Specific Function Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Pathways
  • Steroid Biosynthesis
Reactions
4,4-Dimethylcholesta-8,14,24-trienol + NADPH → 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADP details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 29
Locus Not Available
SNPs TM7SF2
Gene Sequence
>1257 bp
ATGGCCCCTCCTCAGGGCTCTCGGGCCCCGCTGGAATTCGGAGGACCCTTGGGCGCCGCG
GCGCTGATGCTGCTGCTCCCGGTCACTATGTTCCACCTGCTACTGGTGGCCCGCTCGGGC
CCGGCGCGCCTCCTGGGCCCACCCCCCTACCTGCCGGGACCGGAGGAGCTGTGGAGCCCG
TGGGCGCTGTTGCTCTGTCTCACCTGGCTCGGCCTGCAGGCGGCGCTCTACCTCTTGCCG
GCGCGTAAGGTGGCTGAGGGGCAGGAATTGAAGGACAAGAGTCGACTGCGCTACCCCACT
AACGGCTTCCAGGCCCTGGTGCTGACAGCCCTCTTGGTGGGCCTGGGGGTGTCAGCCGGG
CTGCCCCTGAGCGCGCTCCCGGAAATGCTCTTGCCCTTGGCGTTTGCGGCCACCCTCACC
GCCTTCATCTTCAGCCTCCTTCTGTATCTGAAGGCTCTGCTAGCCCCTGCCTCGGCCCTG
GCACCTGGAGGGAACTCAGGCAATCTCATTTACGACTTTTTCCTGGGACGGGAGCTCAAC
CCGCGCATCTGTTCCTTTGACTTCAAATATTTCTGCGAACTGCGGCCTGGCCTCATCGGC
TGGGTCCTCATCAACCTGGCGTTGCTGATACAGGAAGCAGAACTTCGGGGGAGTCCCTCG
CTGGCCATGTGGCTGGTCAATGGCTTCCAGCTACTGTACGTGGGTGATGCCCTTTGGTAC
GAGGAGGCAGTCCTGACCACCATGGACATCATCCATGACGGGTTTGGCTTCATGCTGGCC
TTTGGGGACCTCGCCTGGGTACCCTTCACCTACAGCCTGCAGGCCCAGTTCCTGCTGTAT
CACCCACAGCCTCTGGGGTGGCCCCTGGCCTCATTCATCTGCCTCATCAATGCTGTTGGT
TACTACATCTTCCGTGGAGCCAATTCTCAGAAAAACACCTTCCGAAAGAATCCTTCTGAT
CCCAGAGTGGCTGACCTTGAGACCATCTCTACAGCCACAGGGCGACGGCTGCTGGTGTCC
GGGTGGTGGGGTATGGTCCGCCATCCCAACTACCTTGGAGACCTCATCATGGCTCTGGCC
TGGTCCTTGCCGTGTGGGGTGTTCCACCTGCTGCCCTACTTCTACTTCCTCTACTTCACC
GCGCTGCTGGTGCACCGTGAGGACCGGGATGAGAGGCAGTGTCGGCAGAAGTATGGCCTG
GCCTGGCACGAGTACTGCCGGCGTGTGCCCTACCGAATCGTGCCCTACGTCTACTGA
Protein Properties
Number of Residues 418
Molecular Weight 46751.0
Theoretical pI 8.25
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 13-35
  • 62-81
  • 102-124
  • 129-148
  • 255-277
  • 287-304
  • 355-377
Protein Sequence
>Delta(14)-sterol reductase
MAPPQGSRAPLEFGGPLGAAALMLLLPVTMFHLLLVARSGPARLLGPPPYLPGPEELWSP
WALLLCLTWLGLQAALYLLPARKVAEGQELKDKSRLRYPTNGFQALVLTALLVGLGVSAG
LPLSALPEMLLPLAFAATLTAFIFSLLLYLKALLAPASALAPGGNSGNLIYDFFLGRELN
PRICSFDFKYFCELRPGLIGWVLINLALLIQEAELRGSPSLAMWLVNGFQLLYVGDALWY
EEAVLTTMDIIHDGFGFMLAFGDLAWVPFTYSLQAQFLLYHPQPLGWPLASFICLINAVG
YYIFRGANSQKNTFRKNPSDPRVADLETISTATGRRLLVSGWWGMVRHPNYLGDLIMALA
WSLPCGVFHLLPYFYFLYFTALLVHREDRDERQCRQKYGLAWHEYCRRVPYRIVPYVY
GenBank ID Protein AAK91505.1
UniProtKB/Swiss-Prot ID Q8WMV1
UniProtKB/Swiss-Prot Entry Name ERG24_BOVIN
PDB IDs Not Available
GenBank Gene ID AY039681
GeneCard ID TM7SF2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available