Identification |
BMDB Protein ID
| BMDBP00996 |
Secondary Accession Numbers
| None |
Name
| Delta(14)-sterol reductase TM7SF2 |
Synonyms
|
Not Available
|
Gene Name
| TM7SF2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in delta14-sterol reductase activity |
Specific Function
| Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. |
Pathways
|
|
Reactions
|
4,4-Dimethylcholesta-8,14,24-trienol + NADPH → 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADP |
details
|
|
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 29 |
Locus
| Not Available |
SNPs
| TM7SF2 |
Gene Sequence
|
>1257 bp
ATGGCCCCTCCTCAGGGCTCTCGGGCCCCGCTGGAATTCGGAGGACCCTTGGGCGCCGCG
GCGCTGATGCTGCTGCTCCCGGTCACTATGTTCCACCTGCTACTGGTGGCCCGCTCGGGC
CCGGCGCGCCTCCTGGGCCCACCCCCCTACCTGCCGGGACCGGAGGAGCTGTGGAGCCCG
TGGGCGCTGTTGCTCTGTCTCACCTGGCTCGGCCTGCAGGCGGCGCTCTACCTCTTGCCG
GCGCGTAAGGTGGCTGAGGGGCAGGAATTGAAGGACAAGAGTCGACTGCGCTACCCCACT
AACGGCTTCCAGGCCCTGGTGCTGACAGCCCTCTTGGTGGGCCTGGGGGTGTCAGCCGGG
CTGCCCCTGAGCGCGCTCCCGGAAATGCTCTTGCCCTTGGCGTTTGCGGCCACCCTCACC
GCCTTCATCTTCAGCCTCCTTCTGTATCTGAAGGCTCTGCTAGCCCCTGCCTCGGCCCTG
GCACCTGGAGGGAACTCAGGCAATCTCATTTACGACTTTTTCCTGGGACGGGAGCTCAAC
CCGCGCATCTGTTCCTTTGACTTCAAATATTTCTGCGAACTGCGGCCTGGCCTCATCGGC
TGGGTCCTCATCAACCTGGCGTTGCTGATACAGGAAGCAGAACTTCGGGGGAGTCCCTCG
CTGGCCATGTGGCTGGTCAATGGCTTCCAGCTACTGTACGTGGGTGATGCCCTTTGGTAC
GAGGAGGCAGTCCTGACCACCATGGACATCATCCATGACGGGTTTGGCTTCATGCTGGCC
TTTGGGGACCTCGCCTGGGTACCCTTCACCTACAGCCTGCAGGCCCAGTTCCTGCTGTAT
CACCCACAGCCTCTGGGGTGGCCCCTGGCCTCATTCATCTGCCTCATCAATGCTGTTGGT
TACTACATCTTCCGTGGAGCCAATTCTCAGAAAAACACCTTCCGAAAGAATCCTTCTGAT
CCCAGAGTGGCTGACCTTGAGACCATCTCTACAGCCACAGGGCGACGGCTGCTGGTGTCC
GGGTGGTGGGGTATGGTCCGCCATCCCAACTACCTTGGAGACCTCATCATGGCTCTGGCC
TGGTCCTTGCCGTGTGGGGTGTTCCACCTGCTGCCCTACTTCTACTTCCTCTACTTCACC
GCGCTGCTGGTGCACCGTGAGGACCGGGATGAGAGGCAGTGTCGGCAGAAGTATGGCCTG
GCCTGGCACGAGTACTGCCGGCGTGTGCCCTACCGAATCGTGCCCTACGTCTACTGA
|
Protein Properties |
Number of Residues
| 418 |
Molecular Weight
| 46751.0 |
Theoretical pI
| 8.25 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
- 13-35
- 62-81
- 102-124
- 129-148
- 255-277
- 287-304
- 355-377
|
Protein Sequence
|
>Delta(14)-sterol reductase
MAPPQGSRAPLEFGGPLGAAALMLLLPVTMFHLLLVARSGPARLLGPPPYLPGPEELWSP
WALLLCLTWLGLQAALYLLPARKVAEGQELKDKSRLRYPTNGFQALVLTALLVGLGVSAG
LPLSALPEMLLPLAFAATLTAFIFSLLLYLKALLAPASALAPGGNSGNLIYDFFLGRELN
PRICSFDFKYFCELRPGLIGWVLINLALLIQEAELRGSPSLAMWLVNGFQLLYVGDALWY
EEAVLTTMDIIHDGFGFMLAFGDLAWVPFTYSLQAQFLLYHPQPLGWPLASFICLINAVG
YYIFRGANSQKNTFRKNPSDPRVADLETISTATGRRLLVSGWWGMVRHPNYLGDLIMALA
WSLPCGVFHLLPYFYFLYFTALLVHREDRDERQCRQKYGLAWHEYCRRVPYRIVPYVY
|
External Links |
GenBank ID Protein
| AAK91505.1 |
UniProtKB/Swiss-Prot ID
| Q8WMV1 |
UniProtKB/Swiss-Prot Entry Name
| ERG24_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AY039681 |
GeneCard ID
| TM7SF2 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |