| Identification |
|---|
| BMDB Protein ID
| BMDBP00996 |
| Secondary Accession Numbers
| None |
| Name
| Delta(14)-sterol reductase TM7SF2 |
| Synonyms
|
Not Available
|
| Gene Name
| TM7SF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in delta14-sterol reductase activity |
| Specific Function
| Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. |
| Pathways
|
|
| Reactions
|
| 4,4-Dimethylcholesta-8,14,24-trienol + NADPH → 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| TM7SF2 |
| Gene Sequence
|
>1257 bp
ATGGCCCCTCCTCAGGGCTCTCGGGCCCCGCTGGAATTCGGAGGACCCTTGGGCGCCGCG
GCGCTGATGCTGCTGCTCCCGGTCACTATGTTCCACCTGCTACTGGTGGCCCGCTCGGGC
CCGGCGCGCCTCCTGGGCCCACCCCCCTACCTGCCGGGACCGGAGGAGCTGTGGAGCCCG
TGGGCGCTGTTGCTCTGTCTCACCTGGCTCGGCCTGCAGGCGGCGCTCTACCTCTTGCCG
GCGCGTAAGGTGGCTGAGGGGCAGGAATTGAAGGACAAGAGTCGACTGCGCTACCCCACT
AACGGCTTCCAGGCCCTGGTGCTGACAGCCCTCTTGGTGGGCCTGGGGGTGTCAGCCGGG
CTGCCCCTGAGCGCGCTCCCGGAAATGCTCTTGCCCTTGGCGTTTGCGGCCACCCTCACC
GCCTTCATCTTCAGCCTCCTTCTGTATCTGAAGGCTCTGCTAGCCCCTGCCTCGGCCCTG
GCACCTGGAGGGAACTCAGGCAATCTCATTTACGACTTTTTCCTGGGACGGGAGCTCAAC
CCGCGCATCTGTTCCTTTGACTTCAAATATTTCTGCGAACTGCGGCCTGGCCTCATCGGC
TGGGTCCTCATCAACCTGGCGTTGCTGATACAGGAAGCAGAACTTCGGGGGAGTCCCTCG
CTGGCCATGTGGCTGGTCAATGGCTTCCAGCTACTGTACGTGGGTGATGCCCTTTGGTAC
GAGGAGGCAGTCCTGACCACCATGGACATCATCCATGACGGGTTTGGCTTCATGCTGGCC
TTTGGGGACCTCGCCTGGGTACCCTTCACCTACAGCCTGCAGGCCCAGTTCCTGCTGTAT
CACCCACAGCCTCTGGGGTGGCCCCTGGCCTCATTCATCTGCCTCATCAATGCTGTTGGT
TACTACATCTTCCGTGGAGCCAATTCTCAGAAAAACACCTTCCGAAAGAATCCTTCTGAT
CCCAGAGTGGCTGACCTTGAGACCATCTCTACAGCCACAGGGCGACGGCTGCTGGTGTCC
GGGTGGTGGGGTATGGTCCGCCATCCCAACTACCTTGGAGACCTCATCATGGCTCTGGCC
TGGTCCTTGCCGTGTGGGGTGTTCCACCTGCTGCCCTACTTCTACTTCCTCTACTTCACC
GCGCTGCTGGTGCACCGTGAGGACCGGGATGAGAGGCAGTGTCGGCAGAAGTATGGCCTG
GCCTGGCACGAGTACTGCCGGCGTGTGCCCTACCGAATCGTGCCCTACGTCTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 418 |
| Molecular Weight
| 46751.0 |
| Theoretical pI
| 8.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 13-35
- 62-81
- 102-124
- 129-148
- 255-277
- 287-304
- 355-377
|
| Protein Sequence
|
>Delta(14)-sterol reductase
MAPPQGSRAPLEFGGPLGAAALMLLLPVTMFHLLLVARSGPARLLGPPPYLPGPEELWSP
WALLLCLTWLGLQAALYLLPARKVAEGQELKDKSRLRYPTNGFQALVLTALLVGLGVSAG
LPLSALPEMLLPLAFAATLTAFIFSLLLYLKALLAPASALAPGGNSGNLIYDFFLGRELN
PRICSFDFKYFCELRPGLIGWVLINLALLIQEAELRGSPSLAMWLVNGFQLLYVGDALWY
EEAVLTTMDIIHDGFGFMLAFGDLAWVPFTYSLQAQFLLYHPQPLGWPLASFICLINAVG
YYIFRGANSQKNTFRKNPSDPRVADLETISTATGRRLLVSGWWGMVRHPNYLGDLIMALA
WSLPCGVFHLLPYFYFLYFTALLVHREDRDERQCRQKYGLAWHEYCRRVPYRIVPYVY
|
| External Links |
|---|
| GenBank ID Protein
| AAK91505.1 |
| UniProtKB/Swiss-Prot ID
| Q8WMV1 |
| UniProtKB/Swiss-Prot Entry Name
| ERG24_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY039681 |
| GeneCard ID
| TM7SF2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
