| Identification |
|---|
| BMDB Protein ID
| BMDBP01000 |
| Secondary Accession Numbers
| None |
| Name
| Enoyl-[acyl-carrier-protein] reductase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| MECR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). |
| Pathways
|
- Fatty Acid Elongation in Mitochondria
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| MECR |
| Gene Sequence
|
>1122 bp
ATGTGGGTTTGCGGGGCGCTCTGCAGGACTCGAGCCCCGGCCCAGCTAGGGCAGAGGCTG
CTCCCAGAGTCCCGCCGGCGGCGGCCTGCCTCCGCCTCCTTCTCTGCCTCTGCTGAGCCT
TCCCGGGTCCGGGCGCTGGTCTATGGGCACCACGGGGACCCAGCCAAGGTCGTCGAACTG
AAGAACCTGGAGCTGGCTGCTGTGGGCGGATCACACGTCCATGTGAAGATGCTGGCGGCC
CCTATCAATCCATCTGACATAAATATGATCCAAGGAAATTACGGCCTCCTTCCCCAGCTG
CCTGCTGTTGGAGGGAACGAAGGTGTTGGACAGGTCGTAGCCGTGGGCAGCGGTGTGACC
GGGGTGAAGCCAGGAGACTGGGTGATCCCAGCGAATCCTGGTTTGGGAACCTGGCGGACC
GAGGCTGTGTTCGGCGAGGAAGAGCTCATCACAGTCCCAAGTGACATCCCTCTTCAGAGC
GCTGCCACGCTGGGCGTCAACCCCTGCACGGCCTACCGGATGCTGGTGGACTTTGAGCGG
CTGCGGCCAAGGGATTCCATCATCCAGAATGCATCCAACAGTGGAGTGGGGCAAGCGGTC
ATCCAAATCGCGGCCGCCCGGGGCCTGAGGACCATCAACGTGCTCCGGGACACACCTGAC
CTCCAGAAGCTGACCGACACACTGAAAAATCTGGGGGCCAACCACGTTGTCACAGAAGAG
GAACTAAGAAAGCCTGAGATGAAAAGCTTCTTTAAGGACGTGCCCCAGCCACGGCTTGCT
CTCAACTGCGTTGGCGGGAAAAGCTCCACGGAGCTGCTGCGGCATTTGGCGCCTGGAGGA
ACCATGGTGACCTATGGGGGAATGGCCAAGCAGCCTGTCATCGCCTCTGTGAGCCAGCTT
ATTTTTAAGGATCTCAAACTTCGGGGCTTTTGGTTATCCCAGTGGAAGAAGGACCACAGT
CCAGACCAGTTCAAGGAGCTGATCCTCACACTCTGCGATCTCATCCGCCGAGGCCAACTC
ACGGCCCCCGCCTGCTCCGAGGTCCCGCTGCAGGACTACCTGTGTGCCCTAGAAGCATCC
ACGCAGCCCTTCGTGTCTTCAAAGCAGATTCTCACCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 373 |
| Molecular Weight
| 40275.0 |
| Theoretical pI
| 9.07 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Trans-2-enoyl-CoA reductase, mitochondrial
MWVCGALCRTRAPAQLGQRLLPESRRRRPASASFSASAEPSRVRALVYGHHGDPAKVVEL
KNLELAAVGGSHVHVKMLAAPINPSDINMIQGNYGLLPQLPAVGGNEGVGQVVAVGSGVT
GVKPGDWVIPANPGLGTWRTEAVFGEEELITVPSDIPLQSAATLGVNPCTAYRMLVDFER
LRPRDSIIQNASNSGVGQAVIQIAAARGLRTINVLRDTPDLQKLTDTLKNLGANHVVTEE
ELRKPEMKSFFKDVPQPRLALNCVGGKSSTELLRHLAPGGTMVTYGGMAKQPVIASVSQL
IFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSEVPLQDYLCALEAS
TQPFVSSKQILTM
|
| External Links |
|---|
| GenBank ID Protein
| AAP45003.1 |
| UniProtKB/Swiss-Prot ID
| Q7YS70 |
| UniProtKB/Swiss-Prot Entry Name
| MECR_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY256973 |
| GeneCard ID
| MECR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
