| Identification |
|---|
| BMDB Protein ID
| BMDBP01001 |
| Secondary Accession Numbers
| |
| Name
| NAD(P) transhydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| NNT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| Not Available |
| SNPs
| NNT |
| Gene Sequence
|
>3261 bp
ATGGCGAACCTACTGAAAACAGTGGTGACTGGTTGTTCATGCCCTTTCCTCAGCAATTTG
GGGTCCTGTAAGGTTCTACCAGGGAAGAAGAATTTTTTACGAACATTTCATACTCATCGG
ATACTGTGGTGTAGTGCCCCTGTAAAACCAGGAATTCCATACAAGCAACTAACTGTTGGG
GTCCCCAAAGAGATTTTCCAAAATGAGAAGCGAGTGGCATTGTCTCCTGCTGGCGTTCAG
GCCTTGGTCAAGCAGGGGTTTAATGTTGTTGTGGAATCTGGCGCAGGTGAAGCTTCCAAG
TTCTCAGATGATCACTACAGAGCAGCAGGTGCCCAGATCCAAGGGGCGAAGGAAGTGCTG
GCTTCTGATTTGGTGGTCAAAGTGCGAGCCCCTATGCTTAACCCAACATTAGGTGTTCAT
GAAGCTGATCTTTTAAAGACATCGGGTACACTGATCAGTTTTATTTACCCAGCCCAAAAT
CCAGACTTGCTAAATAAACTGTCCAAAAGGAAGACGACAGTTCTGGCAATGGACCAGGTT
CCAAGAGTCACAATTGCTCAGGGATATGATGCGCTAAGCTCCATGGCCAACATTGCCGGT
TACAAGGCTGTTGTACTAGCAGCAAATCATTTTGGACGGTTTTTTACTGGTCAGATCACA
GCTGCTGGAAAAGTTCCTCCAGCTAAGATTCTGATAGTTGGTGGTGGCGTTGCTGGGCTG
GCTTCTGCAGGTGCAGCCAAGTCCATGGGTGCCATTGTTAGGGGATTTGATACAAGGGCC
GCAGCTTTGGAGCAGTTTAAGTCTTTGGGTGCTGAGCCCTTGGAGGTGGATTTGAAGGAA
TCTGGTGAGGGACAAGGAGGATACGCAAAGGAGATGTCCAAAGAGTTCATTGAGGCCGAA
ATGAAGCTCTTTGCTCAACAGTGTAAGGAGGTGGACATCCTTATCAGCACAGCTCTTATT
CCAGGTAAAAAAGCTCCCATTTTGTTTAATAAAGAAATGATTGAGTCCATGAAGGAAGGT
TCAGTTGTTGTGGATTTAGCTGCTGAGGCTGGCGGAAATTTTGAAACTACCAAGCCAGGA
GAACTTTATGTTCATAAGGGAATTACTCACATAGGCTACACAGACCTTCCCAGCCGAATG
GCCACTCAGGCCAGCACCCTGTATTCCAACAACATCACCAAGCTTCTGAAGGCCATCAGC
CCAGACAAAGATAATTTTTACTTTGAAGTGAAAGATGACTTTGACTTTGGTACAATGGGT
CACGTCATTAGAGGAACCGTAGTGATGAAGGATGGCCAAGTGATTTTCCCTGCTCCCACA
CCGAAAAATATTCCTCAAGGTGCCCCAGTAAAACAGAAGACAGTGGCAGAGCTGGAGGCT
GAAAAAGCAGCTACTATCACGCCCTTCAGGAAGACGATGACATCGGCTTCTGTCTATACA
GCAGGTCTCACTGGGATACTAGGTTTGGGCATCGCGGCTCCCAATTTAGCCTTTTCCCAG
ATGGTGACCACCTTCGGCTTGGCTGGCATTGTGGGCTACCATACTGTCTGGGGAGTGACT
CCTGCTCTCCACTCACCGCTAATGTCTGTGACTAATGCAATCTCAGGGTTGACTGCAGTC
GGTGGGTTGGTGCTGATGGGAGGACACTTGTATCCTTCCACAACTTCTCAGGGCCTTGCT
GCTCTTGCCACGTTCATATCCTCAGTCAACATTGCAGGTGGCTTTCTGGTGACTCAGAGA
ATGCTGGACATGTTCAAGCGTCCCACTGACCCTCCGGAGTATAATTACCTGTATCTGCTT
CCTGCTGGTACCTTTGTTGGGGGATATTTAGCCTCCCTCTACAGTGGTTATAACATTGAA
CAGATTATGTACCTGGGCTCCGGTCTTTGCTGTGTTGGTGCCCTGGCCGGGCTTTCCACC
CAGGGGACTGCACGTCTTGGCAATGCCCTGGGCATGATTGGGGTGGCTGGAGGCTTGGCA
GCCACCCTCGGAGGCCTAAAACCATGTCCAGAATTGTTAGCTCAGATGTCTGGAGCAATG
GCTTTGGGCGGTACCATTGGATTGACAATTGCGAAACGCATCCAGATTTCGGATTTACCT
CAGTTAGTTGCTGCTTTCCACAGTTTAGTGGGATTGGCAGCTGTGCTTACGTGCATAGCT
GAGTACATCATAGAATATCCACATTTCGCTACGGATGCAGCAGCCAACCTTACCAAGATC
GTGGCCTACCTCGGTACTTACATTGGTGGGGTGACCTTCAGTGGGTCTCTGGTTGCCTAT
GGAAAATTGCAGGGAATCCTGAAGTCCGCCCCTCTCCTGCTCCCTGGGAGGCACCTCCTC
AATGCAGGCCTGCTGGCTGGTAGCGTGGGTGGGATCATCCCCTTCATGATGGACCCCAGC
TTCACCACTGGCATCACCTGTCTGGGCTCTGTGTCAGCCCTCTCTGCTGTCATGGGTGTG
ACTCTGACGGCTGCCATTGGGGGTGCCGACATGCCGGTGGTCATCACTGTGCTGAACAGC
TACTCAGGCTGGGCCCTGTGTGCAGAGGGTTTCCTGCTCAACAACAATCTGCTGACCATT
GTGGGTGCGCTTATTGGCTCCTCGGGCGCAATCCTGTCCTACATCATGTGTGTGGCAATG
AATCGCTCCCTGGCTAATGTGATTCTTGGAGGCTATGGTACCACTTCAACAGCTGGTGGA
AAACCCATGGAAATTTCTGGCACGCATACAGAAATCAACCTTGACAATGCAATTGACATG
ATTCGAGAAGCTAATAGCATTATTATTACTCCAGGCTACGGGCTCTGTGCAGCCAAAGCT
CAGTACCCCATTGCTGATTTGGTGAAGATGCTCTCTGAACAAGGCAAAAAAGTCAGGTTT
GGAATTCACCCAGTTGCAGGCCGGATGCCTGGTCAGCTTAATGTGCTGCTGGCTGAGGCT
GGGGTGCCATATGATATTGTGTTGGAAATGGACGAGATCAATCATGATTTCCCAGACACT
GATTTGGTCCTTGTAATTGGAGCTAATGACACTGTTAATTCAGCAGCTCAAGAAGACCCC
AACTCCATCATTGCAGGCATGCCAGTCCTTGAAGTCTGGAAATCAAAGCAGGTCATTGTT
ATGAAGAGGTCCCTAGGTGTTGGCTATGCTGCAGTGGACAATCCAATCTTCTACAAACCG
AACACAGCCATGCTTCTAGGCGATGCCAAGAAGACGTGTGATGCTCTGCAGGCGAAAGTT
AGAGAATCCTACCAGAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1086 |
| Molecular Weight
| 113854.0 |
| Theoretical pI
| 8.28 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 475-493
- 501-521
- 527-546
- 558-578
- 596-616
- 622-642
- 646-666
- 672-691
- 702-722
- 740-760
- 778-797
- 801-819
- 833-853
- 857-879
|
| Protein Sequence
|
>NAD(P) transhydrogenase, mitochondrial
MANLLKTVVTGCSCPFLSNLGSCKVLPGKKNFLRTFHTHRILWCSAPVKPGIPYKQLTVG
VPKEIFQNEKRVALSPAGVQALVKQGFNVVVESGAGEASKFSDDHYRAAGAQIQGAKEVL
ASDLVVKVRAPMLNPTLGVHEADLLKTSGTLISFIYPAQNPDLLNKLSKRKTTVLAMDQV
PRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGL
ASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAE
MKLFAQQCKEVDILISTALIPGKKAPILFNKEMIESMKEGSVVVDLAAEAGGNFETTKPG
ELYVHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFEVKDDFDFGTMG
HVIRGTVVMKDGQVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMTSASVYT
AGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAV
GGLVLMGGHLYPSTTSQGLAALATFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLL
PAGTFVGGYLASLYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLA
ATLGGLKPCPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIA
EYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLVAYGKLQGILKSAPLLLPGRHLL
NAGLLAGSVGGIIPFMMDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNS
YSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGG
KPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLSEQGKKVRF
GIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDP
NSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKV
RESYQK
|
| External Links |
|---|
| GenBank ID Protein
| AAI14661.1 |
| UniProtKB/Swiss-Prot ID
| P11024 |
| UniProtKB/Swiss-Prot Entry Name
| NNTM_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC114660 |
| GeneCard ID
| NNT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
