Identification
BMDB Protein ID BMDBP01002
Secondary Accession Numbers None
Name Inosine-5'-monophosphate dehydrogenase 2
Synonyms Not Available
Gene Name IMPDH2
Protein Type Enzyme
Biological Properties
General Function Nucleotide transport and metabolism
Specific Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Pathways
  • Purine Metabolism
  • XMP biosynthesis via de novo pathway
  • XMP from IMP: step 1/1
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 22
Locus Not Available
SNPs IMPDH2
Gene Sequence
>1545 bp
ATGGCCGACTACCTGATTAGCGGGGGCACGTCTTATGTGCCGGACGACGGGCTCACGGCA
CAGCAGCTGTTCAACTGCGGGGACGGCCTCACCTACAATGACTTTCTCATTCTCCCCGGG
TACATCGACTTCACTGCAGACCAAGTGGACCTGACCTCTGCTCTAACTAAAAAGATCACT
CTGAAGACCCCACTGGTTTCCTCACCCATGGACACAGTCACAGAGGCTGGGATGGCCATA
GCAATGGCGCTTACGGGTGGTATTGGCTTCATTCATCACAATTGTACACCAGAATTCCAG
GCCAATGAAGTTCGGAAAGTGAAGAAATATGAGCAGGGATTCATCACAGACCCTGTGGTC
CTCAGTCCCAGGGATCGCGTGAGGGATGTGTTTGAAGCCAAGGCCCGGCATGGGTTCTGT
GGTATCCCCATCACTGACACAGGCCGGATGGGAAGCCACCTGGTGGGCATCATCTCCTCA
AGGGACATTGATTTTCTCAAGGAGGAAGAGCATGACCGGCTTTTGGGAGAGATCATGACA
AAGAGGGAAGACTTGGTGGTAGCCCCTGCAGGCATCACATTGAAAGAAGCAAATGAAATT
CTGCAGCGTAGCAAGAAGGGAAAGTTACCCATTGTAAATGAAAATGATGAGCTGGTGGCC
ATCATTGCCCGGACAGACCTGAAGAAAAACCGAGATTACCCACTGGCCTCCAAAGATGCC
AAGAAGCAGCTGCTGTGTGGAGCAGCCATTGGCACTCATGAGGATGACAAGTATCGGCTA
GACTTGCTGTCCCAGGCCGGTGTGGACGTAGTGGTTTTGGATTCTTCCCAAGGAAACTCC
ATCTTCCAGATCAACATGATCAAGTACATCAAAGAGAAATACCCCAGTATCCAAGTCATT
GGAGGGAATGTGGTCACGGCTGCTCAGGCCAAGAACCTCATTGATGCTGGCGTAGATGCC
CTGCGGGTGGGAATGGGCAGTGGCTCCATCTGCATCACTCAGGAAGTGCTGGCCTGCGGG
CGGCCCCAAGCAACAGCTGTTTACAAGGTGTCAGAATATGCGCGGCGTTTTGGTGTTCCT
GTCATTGCTGACGGAGGAATCCAAAATGTGGGCCATATTGCCAAAGCTTTGGCCCTTGGA
GCCTCCACAGTTATGATGGGCTCCCTCCTGGCTGCTACCACTGAGGCCCCTGGCGAGTAC
TTCTTCTCTGATGGAATCCGGCTAAAGAAGTACCGTGGTATGGGTTCTCTCGATGCCATG
GACAAGCATCTCAGCAGCCAGAATCGATATTTCAGTGAAGCAGACAAAATCAAGGTGGCC
CAGGGGGTGTCTGGGGCTGTTCAGGATAAAGGATCCATCCATAAGTTTGTTCCCTACCTG
ATTGCTGGCATCCAGCACTCCTGCCAGGATATTGGTGCCAAGAGTCTGACCCAAGTTCGA
GCCATGATGTATTCTGGGGAGCTCAAGTTTGAGAAGAGAACATCCTCAGCCCAGGTGGAA
GGTGGTGTCCACAGCCTCCATTCGTATGAGAAGCGTCTTTTCTGA
Protein Properties
Number of Residues 514
Molecular Weight 55763.0
Theoretical pI 7.34
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Inosine-5'-monophosphate dehydrogenase 2
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPRDRVRDVFEAKARHGFCGIPITDTGRMGSHLVGIISSRDIDFLKEEEHDRLLGEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLSQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSIQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
GenBank ID Protein AAI04603.1
UniProtKB/Swiss-Prot ID Q3SWY3
UniProtKB/Swiss-Prot Entry Name IMDH2_BOVIN
PDB IDs
GenBank Gene ID BC104602
GeneCard ID IMPDH2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available