| Identification |
|---|
| BMDB Protein ID
| BMDBP01002 |
| Secondary Accession Numbers
| None |
| Name
| Inosine-5'-monophosphate dehydrogenase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| IMPDH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Pathways
|
- Purine Metabolism
- XMP biosynthesis via de novo pathway
- XMP from IMP: step 1/1
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| IMPDH2 |
| Gene Sequence
|
>1545 bp
ATGGCCGACTACCTGATTAGCGGGGGCACGTCTTATGTGCCGGACGACGGGCTCACGGCA
CAGCAGCTGTTCAACTGCGGGGACGGCCTCACCTACAATGACTTTCTCATTCTCCCCGGG
TACATCGACTTCACTGCAGACCAAGTGGACCTGACCTCTGCTCTAACTAAAAAGATCACT
CTGAAGACCCCACTGGTTTCCTCACCCATGGACACAGTCACAGAGGCTGGGATGGCCATA
GCAATGGCGCTTACGGGTGGTATTGGCTTCATTCATCACAATTGTACACCAGAATTCCAG
GCCAATGAAGTTCGGAAAGTGAAGAAATATGAGCAGGGATTCATCACAGACCCTGTGGTC
CTCAGTCCCAGGGATCGCGTGAGGGATGTGTTTGAAGCCAAGGCCCGGCATGGGTTCTGT
GGTATCCCCATCACTGACACAGGCCGGATGGGAAGCCACCTGGTGGGCATCATCTCCTCA
AGGGACATTGATTTTCTCAAGGAGGAAGAGCATGACCGGCTTTTGGGAGAGATCATGACA
AAGAGGGAAGACTTGGTGGTAGCCCCTGCAGGCATCACATTGAAAGAAGCAAATGAAATT
CTGCAGCGTAGCAAGAAGGGAAAGTTACCCATTGTAAATGAAAATGATGAGCTGGTGGCC
ATCATTGCCCGGACAGACCTGAAGAAAAACCGAGATTACCCACTGGCCTCCAAAGATGCC
AAGAAGCAGCTGCTGTGTGGAGCAGCCATTGGCACTCATGAGGATGACAAGTATCGGCTA
GACTTGCTGTCCCAGGCCGGTGTGGACGTAGTGGTTTTGGATTCTTCCCAAGGAAACTCC
ATCTTCCAGATCAACATGATCAAGTACATCAAAGAGAAATACCCCAGTATCCAAGTCATT
GGAGGGAATGTGGTCACGGCTGCTCAGGCCAAGAACCTCATTGATGCTGGCGTAGATGCC
CTGCGGGTGGGAATGGGCAGTGGCTCCATCTGCATCACTCAGGAAGTGCTGGCCTGCGGG
CGGCCCCAAGCAACAGCTGTTTACAAGGTGTCAGAATATGCGCGGCGTTTTGGTGTTCCT
GTCATTGCTGACGGAGGAATCCAAAATGTGGGCCATATTGCCAAAGCTTTGGCCCTTGGA
GCCTCCACAGTTATGATGGGCTCCCTCCTGGCTGCTACCACTGAGGCCCCTGGCGAGTAC
TTCTTCTCTGATGGAATCCGGCTAAAGAAGTACCGTGGTATGGGTTCTCTCGATGCCATG
GACAAGCATCTCAGCAGCCAGAATCGATATTTCAGTGAAGCAGACAAAATCAAGGTGGCC
CAGGGGGTGTCTGGGGCTGTTCAGGATAAAGGATCCATCCATAAGTTTGTTCCCTACCTG
ATTGCTGGCATCCAGCACTCCTGCCAGGATATTGGTGCCAAGAGTCTGACCCAAGTTCGA
GCCATGATGTATTCTGGGGAGCTCAAGTTTGAGAAGAGAACATCCTCAGCCCAGGTGGAA
GGTGGTGTCCACAGCCTCCATTCGTATGAGAAGCGTCTTTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 514 |
| Molecular Weight
| 55763.0 |
| Theoretical pI
| 7.34 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inosine-5'-monophosphate dehydrogenase 2
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPRDRVRDVFEAKARHGFCGIPITDTGRMGSHLVGIISSRDIDFLKEEEHDRLLGEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLSQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSIQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
|
| External Links |
|---|
| GenBank ID Protein
| AAI04603.1 |
| UniProtKB/Swiss-Prot ID
| Q3SWY3 |
| UniProtKB/Swiss-Prot Entry Name
| IMDH2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC104602 |
| GeneCard ID
| IMPDH2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
