Showing Protein Inosine-5'-monophosphate dehydrogenase 1 (BMDBP01003)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP01003 | ||
| Secondary Accession Numbers | None | ||
| Name | Inosine-5'-monophosphate dehydrogenase 1 | ||
| Synonyms | Not Available | ||
| Gene Name | IMPDH1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Nucleotide transport and metabolism | ||
| Specific Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | ||
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 4 | ||
| Locus | Not Available | ||
| SNPs | IMPDH1 | ||
| Gene Sequence |
>1716 bp ATGGAGGAGCCACGCGCTCCGCCAGCAGGGTCGGCGCCGTTCCCGGTGTCTCTGCAGGGA GGCGGAACCGCTGATGTTCCGGAGCCCGGAGCCCGGCAGCACCCGGGACACGAGACGGCG GCGCAACGGTACAGCGCCCGCCTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGAC TACCTGATCAGCGGCGGCACCGGTTACGTGCCCGAGGATGGGCTCACTGCGCAGCAGCTG TTCGCCAACGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGAC TTCACAGCTGATGAAGTGGATCTGACTTCAGCCCTGACTCGGAAGATCACACTAAAGACG CCACTCATCTCATCCCCCATGGACACTGTGACGGAGGCTGACATGGCCATTGCAATGGCT CTGATGGGCGGTATTGGTTTCATTCACCACAACTGCACTCCAGAATTCCAGGCCAATGAG GTGCGGAAGGTCAAGAAATTTGAACAGGGCTTCATCACGGACCCCGTGGTACTAAGCCCC TCGCATACCGTGGGTGACGTGCTGGAGGCCAAGATCCGGCATGGCTTCTCAGGCATCCCC ATCACTGAGACGGGCACCATGGGCAGCAAGCTGGTGGGCATTGTCACCTCCCGAGACATC GACTTCCTTGCCGAGAAGGACCACACCACCCTTCTCAGTGAGGTGATGACCCCACGGAAT GAGCTGGTGGTGGCTCCAGCAGGTGTAACATTGAAAGAGGCAAATGAGATTCTGCAGCGC AGCAAGAAAGGAAAGCTGCCCATTGTCAATGATCGAGATGAGTTAGTGGCCATCATTGCC CGCACTGACCTGAAGAAGAACCGGGACTACCCCCTGGCCTCCAAGGATTCCCACAAGCAG CTGCTGTGCGGGGCGGCTGTGGGCACCCGTGAGGATGACAAATACCGCCTGGACCTGCTC ACCCAGGCGGGCGCTGATGTCATAGTGCTGGACTCATCCCAAGGGAACTCTGTGTATCAG ATCGCCATGGTACACTACATTAAGCAGAAGTACCCCCACCTCCAGGTGATTGGGGGCAAT GTGGTGACAGCAGCTCAGGCCAAGAACCTGATTGACGCTGGTGTGGATGGGCTGCGTGTG GGCATGGGATGCGGCTCCATCTGCATCACCCAGGAAGTGATGGCCTGTGGTCGGCCCCAG GGCACTGCCGTGTACAAAGTGGCTGAGTATGCCCGGCGCTTCGGGGTCCCAGTCATAGCC GACGGCGGCATCCAGACCGTGGGGCACGTGGTTAAGGCGCTGGCCCTCGGAGCCTCCACA GTGATGATGGGTTCCCTGCTCGCGGCCACCACGGAGGCCCCCGGCGAATACTTCTTCTCG GATGGTGTGAGGCTCAAGAAGTACCGCGGCATGGGCTCGCTGGACGCCATGGAGAAGAGC AGCAGCAGCCAGAAACGCTACTTCAGCGAGGGGGACAAGGTGAAGATTGCGCAGGGCGTC TCGGGCTCTATCCAGGACAAAGGCTCCATTCAGAAGTTCGTGCCCTACCTCATAGCGGGC ATCCAGCACGGCTGCCAGGACATCGGGGCCCGGAGTCTGTCTGTCCTGCGGTCCATGATG TACTCAGGAGAGCTCAAGTTTGAGAAGCGGACCATGTCGGCCCAGATCGAGGGCGGCGTC CACGGCCTGCACTCTTACGAGAAGCGGCTGTACTGA |
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| Protein Properties | |||
| Number of Residues | 514 | ||
| Molecular Weight | 55424.0 | ||
| Theoretical pI | 6.75 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Inosine-5'-monophosphate dehydrogenase MEEPRAPPAGSAPFPVSLQGGGTADVPEPGARQHPGHETAAQRYSARLLQAGYEPESMAD YLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFTADEVDLTSALTRKITLKT PLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSP SHTVGDVLEAKIRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRN ELVVAPAGVTLKEANEILQRSKKGKLPIVNDRDELVAIIARTDLKKNRDYPLASKDSHKQ LLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGN VVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIA DGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKS SSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMM YSGELKFEKRTMSAQIEGGVHGLHSYEKRLY |
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| External Links | |||
| GenBank ID Protein | AAI26585.1 | ||
| UniProtKB/Swiss-Prot ID | A0JNA3 | ||
| UniProtKB/Swiss-Prot Entry Name | IMDH1_BOVIN | ||
| PDB IDs | |||
| GenBank Gene ID | DAAA02011497 | ||
| GeneCard ID | IMPDH1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||