Showing Protein Inosine-5'-monophosphate dehydrogenase 1 (BMDBP01003)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 metabolites
Identification
BMDB Protein ID BMDBP01003
Secondary Accession Numbers None
Name Inosine-5'-monophosphate dehydrogenase 1
Synonyms Not Available
Gene Name IMPDH1
Protein Type Enzyme
Biological Properties
General Function Nucleotide transport and metabolism
Specific Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Pathways
  • Purine Metabolism
  • XMP biosynthesis via de novo pathway
  • XMP from IMP: step 1/1
Reactions
Inosinic acid + NAD + Water → Xanthylic acid + NADH details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 4
Locus Not Available
SNPs IMPDH1
Gene Sequence 
>1716 bp
ATGGAGGAGCCACGCGCTCCGCCAGCAGGGTCGGCGCCGTTCCCGGTGTCTCTGCAGGGA
GGCGGAACCGCTGATGTTCCGGAGCCCGGAGCCCGGCAGCACCCGGGACACGAGACGGCG
GCGCAACGGTACAGCGCCCGCCTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGAC
TACCTGATCAGCGGCGGCACCGGTTACGTGCCCGAGGATGGGCTCACTGCGCAGCAGCTG
TTCGCCAACGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGAC
TTCACAGCTGATGAAGTGGATCTGACTTCAGCCCTGACTCGGAAGATCACACTAAAGACG
CCACTCATCTCATCCCCCATGGACACTGTGACGGAGGCTGACATGGCCATTGCAATGGCT
CTGATGGGCGGTATTGGTTTCATTCACCACAACTGCACTCCAGAATTCCAGGCCAATGAG
GTGCGGAAGGTCAAGAAATTTGAACAGGGCTTCATCACGGACCCCGTGGTACTAAGCCCC
TCGCATACCGTGGGTGACGTGCTGGAGGCCAAGATCCGGCATGGCTTCTCAGGCATCCCC
ATCACTGAGACGGGCACCATGGGCAGCAAGCTGGTGGGCATTGTCACCTCCCGAGACATC
GACTTCCTTGCCGAGAAGGACCACACCACCCTTCTCAGTGAGGTGATGACCCCACGGAAT
GAGCTGGTGGTGGCTCCAGCAGGTGTAACATTGAAAGAGGCAAATGAGATTCTGCAGCGC
AGCAAGAAAGGAAAGCTGCCCATTGTCAATGATCGAGATGAGTTAGTGGCCATCATTGCC
CGCACTGACCTGAAGAAGAACCGGGACTACCCCCTGGCCTCCAAGGATTCCCACAAGCAG
CTGCTGTGCGGGGCGGCTGTGGGCACCCGTGAGGATGACAAATACCGCCTGGACCTGCTC
ACCCAGGCGGGCGCTGATGTCATAGTGCTGGACTCATCCCAAGGGAACTCTGTGTATCAG
ATCGCCATGGTACACTACATTAAGCAGAAGTACCCCCACCTCCAGGTGATTGGGGGCAAT
GTGGTGACAGCAGCTCAGGCCAAGAACCTGATTGACGCTGGTGTGGATGGGCTGCGTGTG
GGCATGGGATGCGGCTCCATCTGCATCACCCAGGAAGTGATGGCCTGTGGTCGGCCCCAG
GGCACTGCCGTGTACAAAGTGGCTGAGTATGCCCGGCGCTTCGGGGTCCCAGTCATAGCC
GACGGCGGCATCCAGACCGTGGGGCACGTGGTTAAGGCGCTGGCCCTCGGAGCCTCCACA
GTGATGATGGGTTCCCTGCTCGCGGCCACCACGGAGGCCCCCGGCGAATACTTCTTCTCG
GATGGTGTGAGGCTCAAGAAGTACCGCGGCATGGGCTCGCTGGACGCCATGGAGAAGAGC
AGCAGCAGCCAGAAACGCTACTTCAGCGAGGGGGACAAGGTGAAGATTGCGCAGGGCGTC
TCGGGCTCTATCCAGGACAAAGGCTCCATTCAGAAGTTCGTGCCCTACCTCATAGCGGGC
ATCCAGCACGGCTGCCAGGACATCGGGGCCCGGAGTCTGTCTGTCCTGCGGTCCATGATG
TACTCAGGAGAGCTCAAGTTTGAGAAGCGGACCATGTCGGCCCAGATCGAGGGCGGCGTC
CACGGCCTGCACTCTTACGAGAAGCGGCTGTACTGA
Protein Properties
Number of Residues 514
Molecular Weight 55424.0
Theoretical pI 6.75
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Inosine-5'-monophosphate dehydrogenase
MEEPRAPPAGSAPFPVSLQGGGTADVPEPGARQHPGHETAAQRYSARLLQAGYEPESMAD
YLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFTADEVDLTSALTRKITLKT
PLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSP
SHTVGDVLEAKIRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRN
ELVVAPAGVTLKEANEILQRSKKGKLPIVNDRDELVAIIARTDLKKNRDYPLASKDSHKQ
LLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGN
VVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIA
DGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKS
SSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMM
YSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
GenBank ID Protein AAI26585.1
UniProtKB/Swiss-Prot ID A0JNA3
UniProtKB/Swiss-Prot Entry Name IMDH1_BOVIN
PDB IDs
GenBank Gene ID DAAA02011497
GeneCard ID IMPDH1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available