| Identification |
|---|
| BMDB Protein ID
| BMDBP01016 |
| Secondary Accession Numbers
| None |
| Name
| Pyrroline-5-carboxylate reductase 3 |
| Synonyms
|
Not Available
|
| Gene Name
| PYCR3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. |
| Pathways
|
- Amino-acid biosynthesis
- L-proline biosynthesis
- L-proline from L-glutamate 5-semialdehyde: step 1/1
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| PYCR3 |
| Gene Sequence
|
>927 bp
ATGGCGGCGGCGGCGGAGGAGTCCGGCTGGAGGCGAGTGGGCTTCGTGGGCGCGGGCCGC
ATGGCGGAGGCCATCGCCCAGGGCCTCATCCAAGCAGGAAAAGTGGAAGCTGAGCACGTG
CTGGCCAGCGCGCCCTCCGACAGGAACCTCTGCCGTTTCCGGGCCATGGGCTGCCAGACC
ACCCACTCCAACCTGGAGGTGCTGCATAGCTGCTCCCTCGTCTTCTTCGCCACCAAACCC
CACATCCTGCCGGCTGTGCTGGTGGAGGTGGCTCCTGCCGTCACTGCTGAGCACATCTTG
GTGTCTGTGGCCGCCGGGGTGTCCCTAAGCACCCTGGAGAAGCTGCTGCCCCCGATGGCT
CGGGTGCTCAGGGTCTCACCCAACCTGCCCTGCATCGTCCAGGAGGGTGCCATGGTGATG
GCGCGGGGCTGCTGCGCTGGGAGCTATGAGGCCCAGCTCCTGCGGTCCCTGCTGGAGGCC
TGTGGGCAGTGCGAGGAGGTGCCTGAGGCCCAGGTGGACGTCCATACCGGCCTCAGCGGC
AGCGGCGTAGCCTTTGTGTGTGCCTTCTCCGAGGCCTTGGCCGAAGGTGCCATCAAAATG
GGCATGCCCAGTGGCCTGGCCCACCGCATTGCTGCCCAGACCCTGCTGGGGACGGCCAAG
GTGCTTCTGCAGAAGGGGCAGCACCCAGCTCAGCTGCGGACTGACGTGTGCACGCCGGGC
GGCACTACCATCTACGGGCTCCATGTGCTGGAGCAAGGCGGGCTGCGGGCCACAGCCATG
AGCGCTGTGGAGGCTGCCACCTGCCGGGCCAGGGAGCTCAGCAGGAACCCCTCCCCCGTG
GTGGCTCAGGTCCCCTCTGTCCTGCAAGCCCTGCAGGGAGAAGGGGCCCTGGCCCACAGG
GAACACAGCAGTGTGGCCCGTTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 308 |
| Molecular Weight
| 32035.0 |
| Theoretical pI
| 7.26 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyrroline-5-carboxylate reductase 3
MAAAAEESGWRRVGFVGAGRMAEAIAQGLIQAGKVEAEHVLASAPSDRNLCRFRAMGCQT
THSNLEVLHSCSLVFFATKPHILPAVLVEVAPAVTAEHILVSVAAGVSLSTLEKLLPPMA
RVLRVSPNLPCIVQEGAMVMARGCCAGSYEAQLLRSLLEACGQCEEVPEAQVDVHTGLSG
SGVAFVCAFSEALAEGAIKMGMPSGLAHRIAAQTLLGTAKVLLQKGQHPAQLRTDVCTPG
GTTIYGLHVLEQGGLRATAMSAVEAATCRARELSRNPSPVVAQVPSVLQALQGEGALAHR
EHSSVARS
|
| External Links |
|---|
| GenBank ID Protein
| AAX46636.1 |
| UniProtKB/Swiss-Prot ID
| Q58D08 |
| UniProtKB/Swiss-Prot Entry Name
| P5CR3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021789 |
| GeneCard ID
| PYCR3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
