| Identification |
|---|
| BMDB Protein ID
| BMDBP01018 |
| Secondary Accession Numbers
| None |
| Name
| Pyrroline-5-carboxylate reductase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| PYCR2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity). |
| Pathways
|
- Amino-acid biosynthesis
- Arginine and Proline Metabolism
- L-proline biosynthesis
- L-proline from L-glutamate 5-semialdehyde: step 1/1
|
| Reactions
|
| L-Proline + NAD → 1-Pyrroline-5-carboxylic acid + NADH |
details
|
| Hydroxyproline + NAD → Pyrroline hydroxycarboxylic acid + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| PYCR2 |
| Gene Sequence
|
>963 bp
ATGAGCGTGGGTTTCATCGGCGCCGGCCAGCTGGCCTGCGCCTTGGCGCGGGGCTTCACG
GCCGCAGGCATCCTGTCGGCTCACAAAATAATAGCCAGCTCCCCGGAAATGGACCTGCCC
ACGGTGTCCGCTCTCAGGAAGATGGGTGTGAACCTGACCCGGAGCAACAAGGAGACGGTC
AGGCACAGTGACGTCCTGTTCCTGGCCGTGAAGCCACACATCATCCCCTTTATCCTGGAC
GAGATCGGTGCCGACGTCCAGGCCAGGCACATCGTGGTGTCCTGTGCGGCTGGCGTCACC
ATCAGCTCTGTGGAAAAGAAGCTGATGGCGTTCCAGCCGGCACCCAAAGTGATCCGCTGC
ATGACCAACACACCTGTGTTGGTGCGGGAGGGTGCAACAGTGTATGCCACAGGCACCCAC
GCCTTGGTGGAGGACGGGCAGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTCTGCACG
GAGGTGGAGGAGGACCTGATCGATGCCGTCACAGGGCTCAGCGGCAGCGGGCCTGCCTAT
GCGTTCATGGCCCTGGACGCATTGGCTGACGGTGGGGTGAAGATGGGCCTGCCACGGCGC
CTGGCCGTCCGACTGGGGGCCCAGGCCTTGCTGGGAGCTGCCAAGATGCTGCTGGACTCA
GAACAGCATCCCGGCCAGCTCAAGGACAACGTGTGCTCCCCTGGGGGGGCCACCATCCAC
GCCCTGCACTTCCTAGAGAGCGGGGGCTTCCGCTCCCTGCTCATCAATGCGGTTGAGGCC
TCCTGTATCCGAACACGAGAGCTGCAGTCCATGGCTGACCAAGAGAAGATCTCCCCAGCT
GCCCTCAAGAAGACCCTCCTGGACAGAGTGAAGCTGGAATCCCCCACAGTGACCACACTG
ACCCCAACCAGCTCAGGGAAGCTCCTCACGAGAAGCCCAGTCCCAGGAGGCAAGAAGGAC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 320 |
| Molecular Weight
| 33630.0 |
| Theoretical pI
| 8.15 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyrroline-5-carboxylate reductase 2
MSVGFIGAGQLACALARGFTAAGILSAHKIIASSPEMDLPTVSALRKMGVNLTRSNKETV
RHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVLVREGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVTTL
TPTSSGKLLTRSPVPGGKKD
|
| External Links |
|---|
| GenBank ID Protein
| AAI18325.1 |
| UniProtKB/Swiss-Prot ID
| Q17QJ7 |
| UniProtKB/Swiss-Prot Entry Name
| P5CR2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118324 |
| GeneCard ID
| PYCR2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
