Showing Protein Pyrroline-5-carboxylate reductase 2 (BMDBP01018)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 metabolites
Identification
BMDB Protein ID BMDBP01018
Secondary Accession Numbers None
Name Pyrroline-5-carboxylate reductase 2
Synonyms Not Available
Gene Name PYCR2
Protein Type Enzyme
Biological Properties
General Function Amino acid transport and metabolism
Specific Function Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).
Pathways
  • Amino-acid biosynthesis
  • Arginine and Proline Metabolism
  • L-proline biosynthesis
  • L-proline from L-glutamate 5-semialdehyde: step 1/1
Reactions
L-Proline + NAD → 1-Pyrroline-5-carboxylic acid + NADH details
Hydroxyproline + NAD → Pyrroline hydroxycarboxylic acid + NADH details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 16
Locus Not Available
SNPs PYCR2
Gene Sequence 
>963 bp
ATGAGCGTGGGTTTCATCGGCGCCGGCCAGCTGGCCTGCGCCTTGGCGCGGGGCTTCACG
GCCGCAGGCATCCTGTCGGCTCACAAAATAATAGCCAGCTCCCCGGAAATGGACCTGCCC
ACGGTGTCCGCTCTCAGGAAGATGGGTGTGAACCTGACCCGGAGCAACAAGGAGACGGTC
AGGCACAGTGACGTCCTGTTCCTGGCCGTGAAGCCACACATCATCCCCTTTATCCTGGAC
GAGATCGGTGCCGACGTCCAGGCCAGGCACATCGTGGTGTCCTGTGCGGCTGGCGTCACC
ATCAGCTCTGTGGAAAAGAAGCTGATGGCGTTCCAGCCGGCACCCAAAGTGATCCGCTGC
ATGACCAACACACCTGTGTTGGTGCGGGAGGGTGCAACAGTGTATGCCACAGGCACCCAC
GCCTTGGTGGAGGACGGGCAGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTCTGCACG
GAGGTGGAGGAGGACCTGATCGATGCCGTCACAGGGCTCAGCGGCAGCGGGCCTGCCTAT
GCGTTCATGGCCCTGGACGCATTGGCTGACGGTGGGGTGAAGATGGGCCTGCCACGGCGC
CTGGCCGTCCGACTGGGGGCCCAGGCCTTGCTGGGAGCTGCCAAGATGCTGCTGGACTCA
GAACAGCATCCCGGCCAGCTCAAGGACAACGTGTGCTCCCCTGGGGGGGCCACCATCCAC
GCCCTGCACTTCCTAGAGAGCGGGGGCTTCCGCTCCCTGCTCATCAATGCGGTTGAGGCC
TCCTGTATCCGAACACGAGAGCTGCAGTCCATGGCTGACCAAGAGAAGATCTCCCCAGCT
GCCCTCAAGAAGACCCTCCTGGACAGAGTGAAGCTGGAATCCCCCACAGTGACCACACTG
ACCCCAACCAGCTCAGGGAAGCTCCTCACGAGAAGCCCAGTCCCAGGAGGCAAGAAGGAC
TAA
Protein Properties
Number of Residues 320
Molecular Weight 33630.0
Theoretical pI 8.15
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Pyrroline-5-carboxylate reductase 2
MSVGFIGAGQLACALARGFTAAGILSAHKIIASSPEMDLPTVSALRKMGVNLTRSNKETV
RHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVLVREGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVTTL
TPTSSGKLLTRSPVPGGKKD
GenBank ID Protein AAI18325.1
UniProtKB/Swiss-Prot ID Q17QJ7
UniProtKB/Swiss-Prot Entry Name P5CR2_BOVIN
PDB IDs Not Available
GenBank Gene ID BC118324
GeneCard ID PYCR2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available