| Identification |
|---|
| BMDB Protein ID
| BMDBP01020 |
| Secondary Accession Numbers
| None |
| Name
| Putative oxidoreductase GLYR1 |
| Synonyms
|
Not Available
|
| Gene Name
| GLYR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes. Binds DNA (in vitro). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Putative oxidoreductase. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| GLYR1 |
| Gene Sequence
|
>810 bp
ATGGCGGCTGTGAGTCTGCGGCTCGGCGATTTGGTGTGGGGGAAACTCGGCCGGTATCCT
CCTTGGCCGGGAAAGATTGTTAACCCACCCAAGGACTTAAAGAAACCACGTGGGAAGAAA
TGCTTCTTTGTAAAGTTTTTTGGAACAGAAGATCATGCCTGGATCAAAGTGGAACAGCTC
AAGCCCTATCATGCACATAAGGAGGAAATGATAAAGATCAACAAGGGGAAGCGATTCCAG
CAAGCTGTGGACGCCGTGGAGGAGTTCCTCAGGAGAGCCAAAGGGAAGGACCAGACATCA
TCCCACAGTTCTGCTGATGACAAGAATCGGCGTAATTCCAGTGAGGAGAGAAGTAGGCCA
ATCTCAGGTGATGAGAAGCGCAAGCTTAGCCTGTCTGAAGGGAAGGTGAAGAAGAACATG
GGAGAAGGAAAGAAGAGGGTGCCTTCAGGCTCCTCAGAGCGAGGCTCCAAGTCCCCTCTG
AAGAGAGCCCAGGAGCAGAGTCCCCGGAAGCGGGGTCGGCCCCCCAAGGACGAGAAGGAC
CTCAGCATCCCTGAGTCTAGTACTGTGAAGGGGATGATGGCTGGACCCATGGCCACGTTT
AAATGGCAGCCGAACGTGAGTGAGCCTGTTAAAGATGCAGACCCTCATTTCCATCACTTC
CTGCTCAGCCAAACTGAGAAGCCAGCTGTCTGTTACCAGGCAATCACAAAGAAGTTGAAA
ATATGTGAAGAGGAGACGGGGTCCACCTCCATCCAGGCCGCAGACAGCACGGCGGTGAAT
GGCAGCGTCACACCCACAGACAAAAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 553 |
| Molecular Weight
| 60556.0 |
| Theoretical pI
| 9.7 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nuclear protein NP60
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQL
KPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHSSADDKNRRNSSEERSRP
ISGDEKRKLSLSEGKVKKNMGEGKKRVPSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKD
LSIPESSTVKGMMAGPMATFKWQPNVSEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLK
ICEEETGSTSIQAADSTAVNGSVTPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTA
EKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDM
STVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAM
GKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASI
FLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQS
DNDMSAVYRAYIH
|
| External Links |
|---|
| GenBank ID Protein
| AAX46521.1 |
| UniProtKB/Swiss-Prot ID
| A4FUF0 |
| UniProtKB/Swiss-Prot Entry Name
| GLYR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021674 |
| GeneCard ID
| GLYR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
