Showing Protein 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (BMDBP01022)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 8 metabolites
Identification
BMDB Protein ID BMDBP01022
Secondary Accession Numbers
  • BMDBP03125
Name 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Synonyms Not Available
Gene Name HSD3B
Protein Type Enzyme
Biological Properties
General Function Cell wall/membrane/envelope biogenesis
Specific Function 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Pathways
  • Lipid metabolism
  • Steroid Biosynthesis
Reactions
3 beta,7 alpha-Dihydroxy-5-cholestenoate + NAD → 7 alpha-Hydroxy-3-oxo-4-cholestenoate + NADH details
7-a,27-dihydroxycholesterol + NADP → 7 alpha,26-Dihydroxy-4-cholesten-3-one + NADPH details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 3
Locus 3q12
SNPs HSD3B
Gene Sequence 
>1122 bp
ATGGCAGGGTGGAGCTGCCTCGTGACCGGAGGAGGAGGCTTTCTGGGCCAGAGGATCATC
TGCCTGTTGGTGGAGGAGAAGGATCTGCAGGAAATCCGGGTGCTAGACAAAGTCTTCAGA
CCAGAAGTTCGGGAGGAATTTTCTAAGCTCCAGAGCAAGATCAAGCTGACCCTGCTGGAA
GGAGACATTCTGGATGAGCAGTGCCTGAAGGGGGCCTGCCAGGGCACCTCAGTGGTCATC
CACACCGCCTCTGTCATTGACGTCAGGAATGCTGTCCCGCGAGAGACCATCATGAACGTC
AATGTGAAAGGTACCCAGCTGCTGTTGGAGGCCTGTGTCCAGGCCAGCGTACCGGTCTTT
ATCCACACCAGCACCATAGAAGTGGCTGGGCCCAACTCCTACAGGGAGATCATCCAAGAC
GGCCGTGAAGAAGAGCATCATGAATCGGCATGGTCCTCTCCATACCCATACAGCAAGAAG
CTTGCCGAGAAGGCTGTGCTGGGAGCTAATGGGTGGGCTCTGAAAAATGGTGGCACCTTG
TACACTTGTGCCCTGAGGCCCATGTACATCTACGGGGAGGGGAGCCCATTCCTTTCTGCC
TACATGCACGGAGCCTTGAATAACAACGGCATCCTGACCAATCACTGCAAGTTCTCAAGA
GTCAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACATTCTGGCCTTGAGGGCCCTG
AGGGACCCCAAAAAGGTCCCAAACATCCAAGGACAGTTCTACTACATCTCAGACGACACG
CCACACCAAAGCTACGATGACCTCAATTACACTTTGAGCAAAGAATGGGGCTTCTGCCTG
GATTCCCGGATGAGCCTTCCTATTTCTCTGCAGTACTGGCTTGCCTTCCTGCTGGAAATA
GTGAGCTTCCTGCTCAGTCCAATTTACAAATATAACCCTTGCTTCAACCGCCACCTAGTG
ACTCTTTCCAACAGCGTGTTCACCTTCTCCTATAAGAAAGCTCAGCGAGATCTGGGGTAT
GAGCCCCTCTACACTTGGGAGGAAGCCAAGCAGAAAACCAAGGAGTGGATTGGCTCCCTG
GTGAAACAGCACAAAGAGACCCTGAAAACAAAGATTCACTGA
Protein Properties
Number of Residues 373
Molecular Weight 42220.0
Theoretical pI 7.96
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 288-308
Protein Sequence 
>3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
MAGWSCLVTGGGGFLGQRIICLLVEEKDLQEIRVLDKVFRPEVREEFSKLQSKIKLTLLE
GDILDEQCLKGACQGTSVVIHTASVIDVRNAVPRETIMNVNVKGTQLLLEACVQASVPVF
IHTSTIEVAGPNSYREIIQDGREEEHHESAWSSPYPYSKKLAEKAVLGANGWALKNGGTL
YTCALRPMYIYGEGSPFLSAYMHGALNNNGILTNHCKFSRVNPVYVGNVAWAHILALRAL
RDPKKVPNIQGQFYYISDDTPHQSYDDLNYTLSKEWGFCLDSRMSLPISLQYWLAFLLEI
VSFLLSPIYKYNPCFNRHLVTLSNSVFTFSYKKAQRDLGYEPLYTWEEAKQKTKEWIGSL
VKQHKETLKTKIH
GenBank ID Protein CAA35615.1
UniProtKB/Swiss-Prot ID P14893
UniProtKB/Swiss-Prot Entry Name 3BHS_BOVIN
PDB IDs Not Available
GenBank Gene ID X17614
GeneCard ID HSD3B
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available