| Identification |
|---|
| BMDB Protein ID
| BMDBP01024 |
| Secondary Accession Numbers
| None |
| Name
| Pyrroline-5-carboxylate reductase 1, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| PYCR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. |
| Pathways
|
- Amino-acid biosynthesis
- L-proline biosynthesis
- L-proline from L-glutamate 5-semialdehyde: step 1/1
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| PYCR1 |
| Gene Sequence
|
>963 bp
ATGAGCGTGGGCTTCATCGGGGCTGGCCAGTTGGCCTTTGCGCTGGCCAAGGGCTTCACA
GCAGCAGGTGTTGTTGCTGCCCACAAGATAATGGCCAGTTCTCCAGACATGGACCTGGCC
ACCGTTTCTGCCCTCAGGAAGATGGGGGTGAACCTCACGCATCACAACAAGGAGACCGTG
CAGCACAGCGACGTGCTCTTCCTGGCCGTGAAGCCACACATCATCCCCTTCATCCTGGAT
GAGATCGCCGCCAACATTGAGGCTCGGCACATCGTGGTGTCCTGTGCAGCCGGTGTCACC
ATCAGCTCCATTGAGAAGAAGCTGACGGCGTTCCAGCCAGCTCCCAAAGTCATCCGCTGC
ATGACCAACACGCCGGTCGTGGTGCGGGAAGGGGCCACAGTGTATGCCACAGGCACCCAT
GCCCAGGTGGAGGACGGCAGGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTCTGCACG
GAGGTGGAGGAGGACCTGATTGATGCCGTCACAGGGCTCAGTGGCAGTGGCCCAGCCTAT
GCATTCACAGCCCTGGACGCACTGGCTGATGGAGGTGTGAAGATGGGACTTCCAAGACGC
CTGGCAGTCCGCCTCGGGGCCCAGGCTCTGCTGGGGGCTGCCAAGATGCTACTGGACTCT
GAACAGCACCCAGGCCAACTCAAGGACAACGTCTGCTCACCAGGCGGGGCCACGATCCAT
GCGTTGCACGTGCTGGAGAGTGGGGGCTTTCGCTCGCTGCTCATCAAGGCCGTGGAGGCC
TCCTGCACCCGCACACGAGAGCTGCAGTCCATGGCCGACCAGGAGAAGGTCTCACCAGCT
GCCATCAAGAAAACCATCCTGGACAAGGTGAAACTGGACTCCCCTCCCGGCACCTCGCTG
GCCCCTTCTGGCCACTCCAAGCTGCTGCCCCGCAGCATGGCCCCAGCAGGCAAACAGGAC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 320 |
| Molecular Weight
| 33454.0 |
| Theoretical pI
| 7.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyrroline-5-carboxylate reductase 1, mitochondrial
MSVGFIGAGQLAFALAKGFTAAGVVAAHKIMASSPDMDLATVSALRKMGVNLTHHNKETV
QHSDVLFLAVKPHIIPFILDEIAANIEARHIVVSCAAGVTISSIEKKLTAFQPAPKVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIH
ALHVLESGGFRSLLIKAVEASCTRTRELQSMADQEKVSPAAIKKTILDKVKLDSPPGTSL
APSGHSKLLPRSMAPAGKQD
|
| External Links |
|---|
| GenBank ID Protein
| AAX46360.1 |
| UniProtKB/Swiss-Prot ID
| Q58DT4 |
| UniProtKB/Swiss-Prot Entry Name
| P5CR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021513 |
| GeneCard ID
| PYCR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
