| Identification |
|---|
| BMDB Protein ID
| BMDBP01039 |
| Secondary Accession Numbers
| None |
| Name
| Angiotensin-converting enzyme 2 |
| Synonyms
|
Not Available
|
| Gene Name
| ACE2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carboxypeptidase activity |
| Specific Function
| Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| ACE2 |
| Gene Sequence
|
>2415 bp
ATGACAGGCTCTTTCTGGCTCCTTCTCAGCCTTGTTGCTGTAACTGCTGCTCAATCCACC
ACTGAAGAACAGGCCAAGACATTTTTGGAGAAGTTTAACCATGAAGCCGAAGACCTGTCT
TATCAAAGTTCACTTGCTTCTTGGAATTATAACACCAATATTACCGATGAGAATGTCCAA
AAGATGAATGAAGCCAGAGCCAAATGGTCTGCCTTTTATGAAGAACAGTCCCGGATGGCC
AAAACTTACTCACTCGAAGAAATTCAGAATCTCACACTCAAGCGTCAATTGAAGGCCCTT
CAGCATAGCGGGACCTCAGCGCTCTCGGCAGAGAAGAGCAAACGATTGAACACGATTCTA
AATAAAATGAGCACCATCTACAGTACTGGGAAAGTTTTGGACCCAAATACACAGGAGTGC
TTAGCACTTGAACCAGGTTTAGATGACATAATGGAAAACAGCAGAGACTACAATCGGAGG
CTCTGGGCTTGGGAAGGCTGGAGGGCTGAAGTTGGCAAGCAACTAAGGCCATTGTATGAA
GAGTATGTGGTCCTAGAAAATGAGATGGCAAGAGCCAACAATTATGAGGACTACGGGGAC
TATTGGAGAGGGGATTATGAGGTGACTGGGGCAGGGGACTATGACTACAGCCGTGACCAG
TTGATGAAAGATGTGGAACGCACCTTTGCAGAGATTAAACCATTATATGAACAACTTCAT
GCTTATGTGAGGGCAAAGTTGATGCATACCTACCCTTCCTATATCAGCCCTACTGGATGC
CTCCCTGCGCATTTGCTTGGTGATATGTGGGGGAGATTTTGGACAAATCTGTACTCTTTG
ACAGTCCCCTTTGAACACAAACCAAGCATAGATGTTACTGAAAAAATGGAGAACCAGTCC
TGGGATGCAGAAAGGATATTCAAGGAGGCTGAGAAGTTCTTTGTGTCTATCAGCCTTCCT
TACATGACTCAAGGATTCTGGGACAACTCCATGCTGACTGAGCCAGGCGATGGCCGGAAG
GTGGTCTGCCACCCCACAGCGTGGGACTTAGGGAAGGGTGACTTCAGGATCAAGATGTGC
ACGAAGGTCACAATGGATGATTTCCTGACAGCCCATCATGAGATGGGCCACATCCAGTAT
GACATGGCGTATGCCGCACAGCCCTACCTGCTCAGGAATGGCGCTAATGAAGGTTTCCAT
GAGGCTGTCGGGGAAATCATGTCACTGTCCGCAGCCACACCTCACTATTTGAAAGCGCTT
GGTCTTCTGGCACCTGATTTTCATGAAGACAATGAAACAGAAATAAACTTCCTGCTCAAA
CAAGCACTTACAATTGTTGGAACTCTACCATTTACTTACATGTTAGAAAAGTGGAGGTGG
ATGGTCTTTAAGGGTGAAATTCCCAAACAGCAGTGGATGGAAAAGTGGTGGGAGATGAAG
CGAGAGATAGTCGGAGTGGTGGAGCCTCTGCCCCATGATGAGACATACTGTGATCCTGCG
TGTCTGTTCCATGTGGCTGAAGATTACTCATTCATCCGGTATTACACAAGGACCATTTAT
CAATTCCAGTTTCATGAAGCCCTTTGTAAAACAGCTAAACATGAAGGTGCCCTGTTCAAA
TGTGATATCTCAAATTCCACGGAAGCTGGGCAGAGGCTGCTCCAAATGCTGCGCCTTGGA
AAATCAGAACCCTGGACCTTAGCATTGGAAAATATTGTGGGCATAAAGACTATGGATGTA
AAACCCCTGCTCAACTACTTTGAGCCCTTGTTTACCTGGCTGAAAGAGCAGAACAGGAAT
TCATTCGTGGGATGGAGCACGGAATGGACTCCATATTCTGACCAAAGCATCAAAGTGAGG
ATAAGCCTAAAATCAGCTCTTGGAGAAAATGCTTATGAATGGAATGACAACGAAATGTAC
TTGTTCCAGTCGTCTGTGGCATATGCCATGAGAAAGTATTTTTCAGAAGCCAGAAATGAG
ACCGTTCTTTTTGGAGAAGACAACGTGTGGGTGAGTGACAAGAAACCAAGGATCTCCTTC
AAGTTCTTTGTCACGTCACCTAACAACGTGTCTGACATCATTCCGAGAACTGAAGTTGAA
AACGCCATCAGGTTGTCCCGGGACCGTATCAATGATGTCTTCCAGCTGGATGACAACAGC
CTGGAGTTTCTGGGGATTCAGCCGACGCTGGGACCCCCTTACGAGCCACCTGTCACCATA
TGGCTGATTATCTTTGGGGTCGTGATGGGAGTGGTAGTGATTGGTATTGTTGTGCTCATC
TTCACTGGGATCAGAAATCGAAGGAAGAAAAATCAAGCAAGCAGTGAAGAAAATCCTTAT
GGCTCTGTGGACTTGAATAAAGGAGAAAATAATTCAGGATTCCAAAATATTGATGATGTT
CAGACTTCGCTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 804 |
| Molecular Weight
| 93067.0 |
| Theoretical pI
| 4.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Angiotensin-converting enzyme 2
MTGSFWLLLSLVAVTAAQSTTEEQAKTFLEKFNHEAEDLSYQSSLASWNYNTNITDENVQ
KMNEARAKWSAFYEEQSRMAKTYSLEEIQNLTLKRQLKALQHSGTSALSAEKSKRLNTIL
NKMSTIYSTGKVLDPNTQECLALEPGLDDIMENSRDYNRRLWAWEGWRAEVGKQLRPLYE
EYVVLENEMARANNYEDYGDYWRGDYEVTGAGDYDYSRDQLMKDVERTFAEIKPLYEQLH
AYVRAKLMHTYPSYISPTGCLPAHLLGDMWGRFWTNLYSLTVPFEHKPSIDVTEKMENQS
WDAERIFKEAEKFFVSISLPYMTQGFWDNSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMC
TKVTMDDFLTAHHEMGHIQYDMAYAAQPYLLRNGANEGFHEAVGEIMSLSAATPHYLKAL
GLLAPDFHEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKQQWMEKWWEMK
REIVGVVEPLPHDETYCDPACLFHVAEDYSFIRYYTRTIYQFQFHEALCKTAKHEGALFK
CDISNSTEAGQRLLQMLRLGKSEPWTLALENIVGIKTMDVKPLLNYFEPLFTWLKEQNRN
SFVGWSTEWTPYSDQSIKVRISLKSALGENAYEWNDNEMYLFQSSVAYAMRKYFSEARNE
TVLFGEDNVWVSDKKPRISFKFFVTSPNNVSDIIPRTEVENAIRLSRDRINDVFQLDDNS
LEFLGIQPTLGPPYEPPVTIWLIIFGVVMGVVVIGIVVLIFTGIRNRRKKNQASSEENPY
GSVDLNKGENNSGFQNIDDVQTSL
|
| External Links |
|---|
| GenBank ID Protein
| AAX46514.1 |
| UniProtKB/Swiss-Prot ID
| Q58DD0 |
| UniProtKB/Swiss-Prot Entry Name
| ACE2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021667 |
| GeneCard ID
| ACE2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
