Showing Protein Angiotensin-converting enzyme 2 (BMDBP01039)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01039 |
| Secondary Accession Numbers | None |
| Name | Angiotensin-converting enzyme 2 |
| Synonyms | Not Available |
| Gene Name | ACE2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in carboxypeptidase activity |
| Specific Function | Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity (By similarity). |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | Not Available |
| Locus | Not Available |
| SNPs | ACE2 |
| Gene Sequence |
>2415 bp ATGACAGGCTCTTTCTGGCTCCTTCTCAGCCTTGTTGCTGTAACTGCTGCTCAATCCACC ACTGAAGAACAGGCCAAGACATTTTTGGAGAAGTTTAACCATGAAGCCGAAGACCTGTCT TATCAAAGTTCACTTGCTTCTTGGAATTATAACACCAATATTACCGATGAGAATGTCCAA AAGATGAATGAAGCCAGAGCCAAATGGTCTGCCTTTTATGAAGAACAGTCCCGGATGGCC AAAACTTACTCACTCGAAGAAATTCAGAATCTCACACTCAAGCGTCAATTGAAGGCCCTT CAGCATAGCGGGACCTCAGCGCTCTCGGCAGAGAAGAGCAAACGATTGAACACGATTCTA AATAAAATGAGCACCATCTACAGTACTGGGAAAGTTTTGGACCCAAATACACAGGAGTGC TTAGCACTTGAACCAGGTTTAGATGACATAATGGAAAACAGCAGAGACTACAATCGGAGG CTCTGGGCTTGGGAAGGCTGGAGGGCTGAAGTTGGCAAGCAACTAAGGCCATTGTATGAA GAGTATGTGGTCCTAGAAAATGAGATGGCAAGAGCCAACAATTATGAGGACTACGGGGAC TATTGGAGAGGGGATTATGAGGTGACTGGGGCAGGGGACTATGACTACAGCCGTGACCAG TTGATGAAAGATGTGGAACGCACCTTTGCAGAGATTAAACCATTATATGAACAACTTCAT GCTTATGTGAGGGCAAAGTTGATGCATACCTACCCTTCCTATATCAGCCCTACTGGATGC CTCCCTGCGCATTTGCTTGGTGATATGTGGGGGAGATTTTGGACAAATCTGTACTCTTTG ACAGTCCCCTTTGAACACAAACCAAGCATAGATGTTACTGAAAAAATGGAGAACCAGTCC TGGGATGCAGAAAGGATATTCAAGGAGGCTGAGAAGTTCTTTGTGTCTATCAGCCTTCCT TACATGACTCAAGGATTCTGGGACAACTCCATGCTGACTGAGCCAGGCGATGGCCGGAAG GTGGTCTGCCACCCCACAGCGTGGGACTTAGGGAAGGGTGACTTCAGGATCAAGATGTGC ACGAAGGTCACAATGGATGATTTCCTGACAGCCCATCATGAGATGGGCCACATCCAGTAT GACATGGCGTATGCCGCACAGCCCTACCTGCTCAGGAATGGCGCTAATGAAGGTTTCCAT GAGGCTGTCGGGGAAATCATGTCACTGTCCGCAGCCACACCTCACTATTTGAAAGCGCTT GGTCTTCTGGCACCTGATTTTCATGAAGACAATGAAACAGAAATAAACTTCCTGCTCAAA CAAGCACTTACAATTGTTGGAACTCTACCATTTACTTACATGTTAGAAAAGTGGAGGTGG ATGGTCTTTAAGGGTGAAATTCCCAAACAGCAGTGGATGGAAAAGTGGTGGGAGATGAAG CGAGAGATAGTCGGAGTGGTGGAGCCTCTGCCCCATGATGAGACATACTGTGATCCTGCG TGTCTGTTCCATGTGGCTGAAGATTACTCATTCATCCGGTATTACACAAGGACCATTTAT CAATTCCAGTTTCATGAAGCCCTTTGTAAAACAGCTAAACATGAAGGTGCCCTGTTCAAA TGTGATATCTCAAATTCCACGGAAGCTGGGCAGAGGCTGCTCCAAATGCTGCGCCTTGGA AAATCAGAACCCTGGACCTTAGCATTGGAAAATATTGTGGGCATAAAGACTATGGATGTA AAACCCCTGCTCAACTACTTTGAGCCCTTGTTTACCTGGCTGAAAGAGCAGAACAGGAAT TCATTCGTGGGATGGAGCACGGAATGGACTCCATATTCTGACCAAAGCATCAAAGTGAGG ATAAGCCTAAAATCAGCTCTTGGAGAAAATGCTTATGAATGGAATGACAACGAAATGTAC TTGTTCCAGTCGTCTGTGGCATATGCCATGAGAAAGTATTTTTCAGAAGCCAGAAATGAG ACCGTTCTTTTTGGAGAAGACAACGTGTGGGTGAGTGACAAGAAACCAAGGATCTCCTTC AAGTTCTTTGTCACGTCACCTAACAACGTGTCTGACATCATTCCGAGAACTGAAGTTGAA AACGCCATCAGGTTGTCCCGGGACCGTATCAATGATGTCTTCCAGCTGGATGACAACAGC CTGGAGTTTCTGGGGATTCAGCCGACGCTGGGACCCCCTTACGAGCCACCTGTCACCATA TGGCTGATTATCTTTGGGGTCGTGATGGGAGTGGTAGTGATTGGTATTGTTGTGCTCATC TTCACTGGGATCAGAAATCGAAGGAAGAAAAATCAAGCAAGCAGTGAAGAAAATCCTTAT GGCTCTGTGGACTTGAATAAAGGAGAAAATAATTCAGGATTCCAAAATATTGATGATGTT CAGACTTCGCTTTAG |
| Protein Properties | |
| Number of Residues | 804 |
| Molecular Weight | 93067.0 |
| Theoretical pI | 4.97 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Angiotensin-converting enzyme 2 MTGSFWLLLSLVAVTAAQSTTEEQAKTFLEKFNHEAEDLSYQSSLASWNYNTNITDENVQ KMNEARAKWSAFYEEQSRMAKTYSLEEIQNLTLKRQLKALQHSGTSALSAEKSKRLNTIL NKMSTIYSTGKVLDPNTQECLALEPGLDDIMENSRDYNRRLWAWEGWRAEVGKQLRPLYE EYVVLENEMARANNYEDYGDYWRGDYEVTGAGDYDYSRDQLMKDVERTFAEIKPLYEQLH AYVRAKLMHTYPSYISPTGCLPAHLLGDMWGRFWTNLYSLTVPFEHKPSIDVTEKMENQS WDAERIFKEAEKFFVSISLPYMTQGFWDNSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMC TKVTMDDFLTAHHEMGHIQYDMAYAAQPYLLRNGANEGFHEAVGEIMSLSAATPHYLKAL GLLAPDFHEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKQQWMEKWWEMK REIVGVVEPLPHDETYCDPACLFHVAEDYSFIRYYTRTIYQFQFHEALCKTAKHEGALFK CDISNSTEAGQRLLQMLRLGKSEPWTLALENIVGIKTMDVKPLLNYFEPLFTWLKEQNRN SFVGWSTEWTPYSDQSIKVRISLKSALGENAYEWNDNEMYLFQSSVAYAMRKYFSEARNE TVLFGEDNVWVSDKKPRISFKFFVTSPNNVSDIIPRTEVENAIRLSRDRINDVFQLDDNS LEFLGIQPTLGPPYEPPVTIWLIIFGVVMGVVVIGIVVLIFTGIRNRRKKNQASSEENPY GSVDLNKGENNSGFQNIDDVQTSL |
| External Links | |
| GenBank ID Protein | AAX46514.1 |
| UniProtKB/Swiss-Prot ID | Q58DD0 |
| UniProtKB/Swiss-Prot Entry Name | ACE2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT021667 |
| GeneCard ID | ACE2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |