Showing Protein Breast cancer type 1 susceptibility protein homolog (BMDBP01041)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01041 |
| Secondary Accession Numbers | None |
| Name | Breast cancer type 1 susceptibility protein homolog |
| Synonyms | Not Available |
| Gene Name | BRCA1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in DNA binding |
| Specific Function | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | BRCA1 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 1849 |
| Molecular Weight | 206279.0 |
| Theoretical pI | 5.29 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Breast cancer type 1 susceptibility protein homolog MDLSADHVEEVQNVLNAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQ CPLCKNDITKRSLQESTRFSQLVEELLKIIHAFELDTGLQFANSYNFSRKEDNSPEHLKE EVSIIQSMGYRNRAKRLWQSEPENPTLQETSLTVELSNLGIVRSLRTKQQTQSQNKSVYI ELGSDSSEDTVNKASYFSVGDHELLEITPQGAKAKTNLNPAEKAACEFSEKDITNTEHHQ LSIKDLITTQKHATETHPEKYQGISVSDFHVEPCGTDTHASSLQHENSSLLLTENRLNVE KAEFCNKSKQPVLVKSQQSRWAESKGTCKDRQIPSTEKKIVLNTDPLYRRKELRKQKPAC PDSPGDSQDVPWVTLNNSIQKVNDWFSRSDEILTSDDSCDGGSESNNEVAGAVEIPNKVD GYSGSSEKINLMASDPHGTLIHERVHSKPVESNIEDKIFGKTYRRKSSLPNFSHIAEDLI LGAFTVEPQITQEQPLTNKLKCKRRGTSGLQPEDFIKKVDLTIVPKTPEKMTEGTDQTEQ KCHGMNITSDGHENKTKRDYVQKEQNANPAESLEKESVFRTEAEPISISISNMELELNIH RSKAPKNRLKRKSSTRKIPELELVVSRNPSLPNHTELPIDSSSSNEEMKKKHSSQMPVRQ SQKLQLIGDKELTAGAKNNKTYEQINKRLASDAFPELKLTNTPGYFTNCSSKPEEFVHPS LQREENLGTIQVSNSTKDPKDLILREGKALQIERSVESTNISLVPDTDYSTQDSISLLEA KTPEKAKTAPNPCVSLCTATKNLKELIHRDFKDTKNNTEGFQDLLGHDINYVIQETSREM EDSELDTQYLQNTFKASKRQTFALFSNPGNPQKECATVFAHSGSLRDQSPRDPLKCRQKE DSQGKSESKSQHVQAICTTVHFPVADQQDRTPGDDAKCSAKEVTRVCQSSQLRGHKTELV FANKQGVSEKPNLIPSLSPIKSSVKTICKKSPSEKFEEPVTSPEKTLGSESIIQSAVSTI SQNNIQESTFKEVSSNSVNEVGSSTNEVGSSVNEVGSSGENIQAEPGRNREPKLRALLGL GLTQPEVYKQSLPVSNCHHPEIKRQGENEDMPQAVKADFSPCLISDNLEQPTGSRHASQV CSETPDNLLNDDEIKENSHFAESDIKERSAVFSESVQKGEFRGSPGPFTHTHLAQGHQRG AGKLESEETVSSEDEELPCFQQLLFGKVTSTLSPSTGCNTVATEGLSKETEGNLESLKSG LNDCSGQVTSAKVSQEHHLNEEARCSGSLFSSQCSAMEDLTTNTNTQDPFLMFERPSKQV YQSESEEVLSDKELVSDDEERETGLEEDSCQEEQSVDSDLGEAVSDHVSETSLSEDGVGL SSQSDILTTQQRDTMQDNLLKLQQEMAELEAVLERHGSQPSHSSASLTADSRGPEHLLNL EQDTSERAILTSEKSRDYSRSQNPESLSADKFPVSLDSSTNKNKEPGMERSSASKFQLSY NRWYMHSSRSLQDRNCPSQKEPINVADMEEQQLAKREAQDLMGSFLPRQDQEGTPYLKSG ISLFSHEPESDPSEDRAAEPAHVHSMPPSASALKLSQFRVEESTKNPAAAHIANTTRCNL REESMSKEKPEVISSTERSKKRLSMVASGLTPKELMLVQKFARKHHVTLTNLITEETTHV IMKTDPEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKEGKMLDEHDFEVRGDVVNGRNHQ GPKRARESRDKKIFKGLEICCYGPFTNMPTDQLEWMVQLCGASVVKEPSSFTPDQGTHPV VVVQPDAWTEDAGFHVIGQMCEAPVVTREWVLDSVALYQCQELDTYLVP |
| External Links | |
| GenBank ID Protein | AAL76094.1 |
| UniProtKB/Swiss-Prot ID | Q864U1 |
| UniProtKB/Swiss-Prot Entry Name | BRCA1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AY077732 |
| GeneCard ID | BRCA1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |