Showing Protein Ubiquitin carboxyl-terminal hydrolase 20 (BMDBP01048)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01048 |
| Secondary Accession Numbers | None |
| Name | Ubiquitin carboxyl-terminal hydrolase 20 |
| Synonyms | Not Available |
| Gene Name | USP20 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in cysteine-type peptidase activity |
| Specific Function | Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 11 |
| Locus | Not Available |
| SNPs | USP20 |
| Gene Sequence |
>2739 bp ATGGGGGACTCCAGGGACCTTTGTCCTCATCTTGACTCGATAGGGGAGGTGACCAAAGAG GACTTGCTGCTCAAATCCAAGAGCACCTGTCAGTCATGCGGGGTTTCTGGACCCAACCTG TGGGCCTGTCTCCAGGTCTCCTGCTCCTACGTTGGCTGCGGAGAATCCTTCGCTGACCAC AGCACCCTGCACGCACAGGCGAAAAAGCACAACCTGACGGTGAACCTGACCACGTTCCGG GTGTGGTGCTACGCCTGTGAGAAGGAAGTGTTCCTGGAGCCGCGCCTGGCGGCCCACCCG CCTGGCCCCGCGCCCAAGTTCTCAGAGCAGGACTCTCCGCCACCCTCCCACCCTCTGAAA GCCGTCCCCATCGCTGTGGCGGACGAAGGAGAGTCCGAGTCGGAGGACGACGACCTGAAG CCACGAGGCCTCACGGGCATGAAGAACCTCGGCAACTCCTGCTACATGAATGCGGCCTTG CAGGCTCTGTCCAACTGCCCCCCGCTCACCCAGTTCTTCTTGGAGTGTGGAGGCCTGGTC CGCACAGACAAGAAGCCAGCCCTGTGCAAAAGTTATCAGAAGCTGGTCTCTGAGGTCTGG CACAGGAAACGCCCCAGCTATGTGGTTCCCACCAGCCTGTCCCATGGGATCAAGTTGGTC AACCCAATGTTCCGAGGCTATGCCCAGCAGGACACCCAGGAATTCTTGCGCTGCCTGATG GACCAGCTGCACGAGGAACTCAAGGAGCCCGTGGTGGCCACAGCGGCGGCGCTGACCGAG GCGCGGGACTCGGACTCGAGCGACACGGATGAGAAGCGGGAGGGTGACCGGAGCCCCTCA GAGGACGAGTTCCTGTCCTGCGACTCCAGCAGCGACCGCGGCGAGGGCGACGGGCAGGGG CGCAGCGGGGGAGGCTCCCAGGCCGAGGCGGAGCTGCTGATGGCGGACGAGGCGGGCCGC GCCATCTCCGAGAAGGAGCGCATGAAGGACCGCAAGTTCTCGTGGGGCCAGCAGCGCACC AACTCGGAGCAGGTGGACGAGGACGCCGACGTGGACACCGCCATGGCCGCCCTGGAGCAG CAGCCCCCGGAGACGCAGCCCCCCTCCCCGCGGTCCACCAGTCCCTGCCGGACGCCAGAG CCGGACAACGAGGCGCACATGCGCAGCTCCCGGCCCTGCAGCCCCGTCCACCACCACGAA GGCCACGCCAAGCTGGCCAGCAGCCCTCATCGTGCGAGCCCTGTGAGGATGGGGCCGGCC TATGTGCTCAAGAAAGCCCAGGTCCCCGGCAGCCGGCGGCGGAAGGAGCAGAGCTACCGC AGCGTCATCTCGGACATCTTCGACGGCTCCGTCCTCAGCCTCGTGCAGTGTCTCACCTGT GACCGGGTGTCCACCACTGTGGAGACATTCCAGGACCTGTCACTGCCCATTCCTGGCAAG GAGGACCTGGCCAAACTCCACTCGGCCATCTACCAGAACGTGCCGGCCAAGCCGGGTGCC TGCGGGGACAGCTATGTGGCCCAGGGCTGGCTTGCCTTTATTGTGGAGTATATCCGACGG TTCGTGGTGTCCTGTACCCCTAGCTGGTTTTGGGGGCCAGTCGTCACCCTGGAAGACTGC CTGGCTGCCTTCTTTGCTGCTGATGAGCTGAAGGGTGACAACATGTACAGCTGTGAACGG TGTAAAAAGCTGCGCAACGGGGTGAAGTACTGTAAGGTCTTGCGGTTGCCGGAGATCCTG TGCATTCACCTGAAGCGCTTTAGGCACGAGGTCATGTACTCTTTCAAGATCAGCAGCCAT GTGTCCTTCCCCCTCGAGGGCCTTGACCTGCGCCCCTTCCTCGCCAAGGAGTGCACGTCC CAGATCACCACCTATGACCTCCTCTCGGTCATCTGCCACCACGGCACGGCAGGCAGTGGC CACTACATCGCCTACTGCCAGAACGTGATCAACGGGCAGTGGTATGAGTTCGACGACCAG TACGTCACCGAGGTCCACGAGACGGTGGTGCAGAACGCGGAGGCCTACGTGCTCTTCTAC AGGAAGAGCAGCGAGGAAGCTGTGCGGGAGCGACAGCAGGTGGTGTCCCTGGCCGCCATG CGGGAGCCCAGCCTGCTGCGGTTCTACGTGTCCCGGGAATGGCTCAACAAGTTTAACACC TTCGCGGAGCCAGGGCCCATCACCAACCACACGTTCCTCTGCTCCCACGGAGGGATCCCG CCCAACAAATATCACTACATCGATGACCTGGTGGTGATCCTGCCGCAGAACGTGTGGGAG CACCTCTACAGCAGGTTTGGGGGCGGCCCCGCTGTGAACCATCTGTACGTGTGCTCCATC TGCCAGGTGGAGATCGAGGCTCTGGCCAAGCGCAGGCGGGTGGAGATCGACACCTTCATC AAGCTGAACAAGGCGTTCCAGGCCGAGGAGTCGCCCAGCGTCATCTACTGTATCAGCATG CAGTGGTTCCGAGAGTGGGAGGCCTTCGTCAAGGGCAAGGACAACGAGCCCCCGGGGCCC ATTGACAACAGCAGGATCGCACAGGTCAAAGGAAGCGGCCACATCCAGCTGAAGCCGGGA GCTGACTATGGGCAGATCTCCGAGGAGACCTGGGTGTACCTGAACAACCTCTATGGCGGC GGCCCCGAGATTGCCATCCGCCAGAGCGTGGCTCAGCTCCCGGACCCGGAGAGCTTGCAC GGTGAACAGAAGATTGAAGCCGAGACCCGGGCCTTGTGA |
| Protein Properties | |
| Number of Residues | 912 |
| Molecular Weight | 101815.0 |
| Theoretical pI | 6.06 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ubiquitin carboxyl-terminal hydrolase MGDSRDLCPHLDSIGEVTKEDLLLKSKSTCQSCGVSGPNLWACLQVSCSYVGCGESFADH STLHAQAKKHNLTVNLTTFRVWCYACEKEVFLEPRLAAHPPGPAPKFSEQDSPPPSHPLK AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV RTDKKPALCKSYQKLVSEVWHRKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM DQLHEELKEPVVATAAALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQG RSGGGSQAEAELLMADEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALEQ QPPETQPPSPRSTSPCRTPEPDNEAHMRSSRPCSPVHHHEGHAKLASSPHRASPVRMGPA YVLKKAQVPGSRRRKEQSYRSVISDIFDGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGK EDLAKLHSAIYQNVPAKPGACGDSYVAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDC LAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKISSH VSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQ YVTEVHETVVQNAEAYVLFYRKSSEEAVRERQQVVSLAAMREPSLLRFYVSREWLNKFNT FAEPGPITNHTFLCSHGGIPPNKYHYIDDLVVILPQNVWEHLYSRFGGGPAVNHLYVCSI CQVEIEALAKRRRVEIDTFIKLNKAFQAEESPSVIYCISMQWFREWEAFVKGKDNEPPGP IDNSRIAQVKGSGHIQLKPGADYGQISEETWVYLNNLYGGGPEIAIRQSVAQLPDPESLH GEQKIEAETRAL |
| External Links | |
| GenBank ID Protein | AAI53255.1 |
| UniProtKB/Swiss-Prot ID | A7Z056 |
| UniProtKB/Swiss-Prot Entry Name | UBP20_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC153254 |
| GeneCard ID | USP20 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |