Showing Protein A disintegrin and metalloproteinase with thrombospondin motifs 2 (BMDBP01049)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01049 |
| Secondary Accession Numbers | None |
| Name | A disintegrin and metalloproteinase with thrombospondin motifs 2 |
| Synonyms | Not Available |
| Gene Name | ADAMTS2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in metalloendopeptidase activity |
| Specific Function | Cleaves the propeptides of type I and II collagen prior to fibril assembly (PubMed:7622483). Does not act on type III collagen (PubMed:7622483). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | ADAMTS2 |
| Gene Sequence |
>3618 bp ATGGATCCGCCGGCGGGAGCCGCCGGCCGCCTGCTCTGCCCCGCGCTGTTGCTGCTCCTG CTGCTGCCGCTGCCCGCGGACGCCCGGCTCGCCGCCGCTGCCGCCGACCCCCCAGGCGGG CCCCAGGGGCACGGAGCCGAGCGCATCCTGGCGGTGCCGGTGCGCACTGACGCCCAGGGC CGCTTGGTGTCCCACGTGGTGTCGGCGGCGACGGCCCCAGCTGGGGTGCGGACCCGCAGG GCCGCCCCTGCCCAGATCCCGGGGCTCTCTGGAGGCAGCGAGGAGGACCCCGGTGGCCGC CTCTTCTACAATGTTACGGTGTTTGGCCGAGACCTGCACCTGCGGCTGCGGCCCAACGCC CGCCTCGTGGCGCCTGGGGCCACGGTGGAGTGGCAGGGAGAATCGGGTGCCACCCGCGTG GAGCCCCTGCTTGGGACCTGCCTCTACGTCGGAGACGTCGCGGGCCTGGCTGAATCCTCT TCCGTGGCGCTCAGCAACTGCGATGGGCTGGCTGGCCTGATCCGTATGGAAGAGGAGGAA TTCTTTATTGAGCCCCTGGAGAAAGGTCTGGCGGCGAAGGAGGCCGAACAGGGCCGTGTA CACGTGGTGTATCATCGACCGACCACCTCCAGACCCCCTCCTCTGGGGGGGCCACAGGCC CTGGACACAGGGATCTCCGCAGACAGCCTGGACAGCCTCAGCCGTGCTCTGGGTGTTCTG GAGGAGCGAGTCAACAGCTCCAGGCGGAGGATGCGCAGGCATGCTGCCGACGACGACTAC AACATCGAGGTCCTGCTTGGGGTGGACGACTCTGTGGTCCAGTTCCACGGGACGGAGCAC GTGCAGAAGTACCTGCTCACCCTCATGAACATTGTCAACGAAATCTATCACGATGAGTCC TTGGGGGCCCACATCAATGTCGTCCTGGTGCGGATAATCCTGCTGAGCTACGGGAAGTCC ATGAGTCTCATTGAGATTGGGAACCCCTCTCAAAGTCTGGAGAATGTTTGCCGCTGGGCC TACCTCCAGCAGAAGCCAGACACTGATCACGACGAGTACCACGATCACGCCATATTCCTC ACACGGCAGGACTTCGGGCCCTCGGGCATGCAAGGCTATGCTCCTGTCACTGGGATGTGC CACCCCGTCCGCAGCTGCACGCTGAACCACGAGGACGGCTTCTCCTCTGCGTTCGTGGTG GCCCACGAGACTGGCCATGTGCTGGGCATGGAGCATGATGGGCAGGGCAACCGCTGCGGT GACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCAGCCTTCCATCGCTTC CACTGGTCCCGCTGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTG CGGGATGACCCCTTCACCCACGACTGGCCGGCGCTGCCCCAGCTCCCCGGGCTGCACTAC TCCATGAACGAGCAGTGCCGTTTCGACTTTGGCCTTGGTTACATGATGTGTACCGCGTTC CGGACCTTCGACCCGTGCAAACAGCTGTGGTGCAGCCACCCTGACAACCCCTACTTTTGC AAGACAAAGAAGGGGCCACCCCTGGATGGGACCATGTGTGCGCCTGGCAAGCACTGCTTT AAAGGACACTGCATCTGGCTGACACCTGACATTCTCAAACGAGATGGCAACTGGGGTGCC TGGAGTCCCTTCGGCTCCTGCTCGCGTACCTGCGGCACAGGTGTGAAGTTCAGGACCCGT CAGTGCGACAACCCACACCCAGCCAATGGGGGCCGCACATGCTCGGGCCTCGCCTACGAT TTCCAGCTCTGCAACTCGCAGGACTGCCCTGACGCGCTGGCCGACTTCCGCGAGGAGCAG TGCCGGCAGTGGGACCTGTACTTCGAGCATGGTGACGCTCAACACCACTGGCTGCCCCAC GAGCACCGGGACGCCAAGGAGCGGTGTCATCTCTACTGTGAGTCCAAGGAGACCGGGGAG GTGGTGTCCATGAAGCGTATGGTGCATGACGGGACACGCTGTTCCTACAAGGACGCCTTC AGCCTCTGCGTGCGTGGGGACTGCAGGAAGGTGGGCTGTGACGGGGTGATCGGCTCCAGC AAGCAGGAGGACAAGTGTGGTGTGTGCGGAGGGGACAACTCCCACTGCAAGGTGGTCAAG GGCACGTTCTCGCGCTCGCCCAAGAAGCTTGGTTACATCAAGATGTTTGAGATCCCGGCA GGAGCCAGACACCTGCTAATCCAGGAAGCAGACACCACCAGCCATCACCTGGCCGTCAAA AACCTGGAGACAGGCAAGTTCATTTTAAATGAGGAGAATGACGTGGATCCCAACTCCAAG ACCTTCATCGCCATGGGCGTGGAGTGGGAGTACCGGGATGAGGACGGCCGGGAGACGCTG CAGACCATGGGCCCCCTCCACGGCACCATCACTGTGCTGGTCATCCCAGAGGGGGACGCC CGCATCTCACTGACCTACAAGTACATGATCCATGAGGACTCGCTCAATGTGGATGACAAC AACGTCCTGGAAGACGACTCTGTGGGCTATGAGTGGGCCCTGAAGAAGTGGTCGCCCTGC TCCAAGCCCTGCGGTGGAGGGTCCCAATTCACCAAGTATGGCTGCCGCCGGAGGCTGGAC CACAAGATGGTGCACCGAGGCTTCTGCGACTCCGTCTCAAAGCCCAAAGCCATCCGCCGG ACCTGCAACCCACAGGAGTGCTCCCAGCCCGTGTGGGTCACGGGTGAGTGGGAGCCGTGC AGCCGGAGCTGTGGGCGGACAGGCATGCAGGTTCGCTCTGTGCGCTGTGTTCAGCCTCTG CACAACAACACCACCCGCTCCGTGCACACCAAGCACTGCAATGACGCTCGACCCGAGGGC CGCCGGGCCTGCAACCGCGAGCTGTGCCCTGGCCGGTGGCGGGCTGGATCCTGGTCCCAG TGCTCAGTAACCTGTGGAAACGGCACCCAGGAACGGCCAGTGCTCTGCCGAACTGCGGAC GACAGTTTCGGGGTGTGCCGGGAGGAGCGGCCTGAGACGGCAAGGATCTGCAGGCTTGGC CCCTGTCCCCGAAACACCTCTGACCCCTCCAAGAAGAGCTACGTGGTCCAGTGGCTATCC CGACCGGACCCCAACTCGCCAGTCCAGGAGACCTCGTCAAAGGGCCGCTGCCAAGGTGAC AAGTCAGTGTTCTGTAGGATGGAAGTCTTGTCTCGTTATTGCTCCATCCCAGGCTACAAT AAGCTGTGCTGCAAGTCCTGTAACCCGCACGACAACCTCACTGATGTGGACGACAGGGCA GAGCCACCCTCTGGGAAGCACAATGACATTGAAGAGCTCATGCCCACCCTTTCAGTGCCC ACTCTAGTCATGGAGGTGCAGCCTCCGCCAGGCATACCCCTGGAGGTGCCTCTCAATACT TCCAGCACCAATGCCACCGAGGACCATCCAGAAACCAATGCTGTGGATGTGCCCTACAAA ATCCCTGGCCTGGAAGATGAAGTCCAGCCACCCAACCTGATCCCTCGACGACCGAGCCCA TATGAAAAGACCAGAAACCAAAGAATCCAAGAGCTCATTGATGAGATGAGGAAGAAAGAG ATGCTCGGAAAGTTCTAA |
| Protein Properties | |
| Number of Residues | 1205 |
| Molecular Weight | 133888.0 |
| Theoretical pI | 6.8 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>A disintegrin and metalloproteinase with thrombospondin motifs 2 MDPPAGAAGRLLCPALLLLLLLPLPADARLAAAAADPPGGPQGHGAERILAVPVRTDAQG RLVSHVVSAATAPAGVRTRRAAPAQIPGLSGGSEEDPGGRLFYNVTVFGRDLHLRLRPNA RLVAPGATVEWQGESGATRVEPLLGTCLYVGDVAGLAESSSVALSNCDGLAGLIRMEEEE FFIEPLEKGLAAKEAEQGRVHVVYHRPTTSRPPPLGGPQALDTGISADSLDSLSRALGVL EERVNSSRRRMRRHAADDDYNIEVLLGVDDSVVQFHGTEHVQKYLLTLMNIVNEIYHDES LGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHDEYHDHAIFL TRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCG DEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPFTHDWPALPQLPGLHY SMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCF KGHCIWLTPDILKRDGNWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYD FQLCNSQDCPDALADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESKETGE VVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVK GTFSRSPKKLGYIKMFEIPAGARHLLIQEADTTSHHLAVKNLETGKFILNEENDVDPNSK TFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPEGDARISLTYKYMIHEDSLNVDDN NVLEDDSVGYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCDSVSKPKAIRR TCNPQECSQPVWVTGEWEPCSRSCGRTGMQVRSVRCVQPLHNNTTRSVHTKHCNDARPEG RRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDSFGVCREERPETARICRLG PCPRNTSDPSKKSYVVQWLSRPDPNSPVQETSSKGRCQGDKSVFCRMEVLSRYCSIPGYN KLCCKSCNPHDNLTDVDDRAEPPSGKHNDIEELMPTLSVPTLVMEVQPPPGIPLEVPLNT SSTNATEDHPETNAVDVPYKIPGLEDEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRKKE MLGKF |
| External Links | |
| GenBank ID Protein | CAA65253.1 |
| UniProtKB/Swiss-Prot ID | P79331 |
| UniProtKB/Swiss-Prot Entry Name | ATS2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | X96389 |
| GeneCard ID | ADAMTS2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |