Showing Protein AFG3-like protein 2 (BMDBP01050)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01050 |
| Secondary Accession Numbers | None |
| Name | AFG3-like protein 2 |
| Synonyms | Not Available |
| Gene Name | AFG3L2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Posttranslational modification, protein turnover, chaperones |
| Specific Function | ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 24 |
| Locus | Not Available |
| SNPs | AFG3L2 |
| Gene Sequence |
>2418 bp ATGGCGCACCGCTGCTTGCTGCTATGGGGCCGGGGCGCCTGCCGGCCCCGCGGGATGCCC CCGATGCTCTTGCCTGGCGGCCGCACGGGCTCCACCGAACGGCTCTACCTGCGGATGCTT TATCGATATGCCACGACTCAGGCGAAAACCAGCAGGAATTCCCTTCTGACAGATGTGATT GCTGCTTATCAGAGACTCTGTTCTCGGCCTCCAAAAGGATTTGAAAAATACTTTCCCAAT GGAAAAAATGGAAAAAAAACTAGTGAACCTAAAGAAGTTATGGGAGAAAAAAAAGAACCC AAGCCAGCTGCTGCCCCGCGTCCTTCTGGAGGAGGAGTTGGTGGCGGTGGAAAACGAGGC GGCAAGAAAGATGACTCTCACTGGTGGTCCAGGTTCCAGAAGGGTGACATCCCATGGGAT GATAAGGAATTCAAGATGTACTTTCTCTGGACCGCCCTGTTTTGGGGAGGATTCCTGTTT TACTTCCTGTTCAAGAGCTCCGGGAGAGAAATCACGTGGAAGGACTTTGCTAACAACTAT CTTTCCAAGGGAGTTGTAGACAGACTGGAAGTTGTCAACAAGCGATTTGTTCGAGTGACT TTTACACCAGGAAAAACTCCTGTTGATGGACAGTACGTCTGGTTCAATATTGGCAGTGTG GACACCTTTGAGCGGAACCTGGAGACGCTGCAGCAGGAACTAGGCATAGAAGGAGAGAAC CGGGTCCCTGTGGTCTACATCGCCGAGAGTGACGGCTCCTTCCTCCTGAGCATGCTGCCC ACCGTGCTCATCATCGCCTTCCTGCTCTACACCATCCGGAGGGGCCCAGCCGGCATCGGC CGCACAGGCCGGGGCATGGGCGGACTCTTCAGTGTTGGAGAGACCACCGCCAAGGTCCTC AAGGATGAGATTGACGTGAAGTTCAAAGACGTGGCCGGCTGTGAGGAGGCCAAGCTGGAG ATCATGGAATTTGTGAATTTCCTAAAAAATCCAAAGCAGTATCAAGACCTGGGAGCAAAA ATCCCAAAGGGTGCCATTCTCACTGGTCCTCCAGGCACTGGGAAGACACTGCTGGCTAAG GCCACGGCTGGAGAAGCCAATGTCCCTTTCATCACCGTTAGCGGGTCTGAGTTCTTGGAG ATGTTTGTTGGTGTAGGCCCAGCTAGAGTCCGTGACTTATTCGCTCTTGCTCGGAAGAAC GCCCCTTGCATCCTCTTCATCGATGAAATAGATGCGGTGGGAAGGAAGAGAGGCAGGGGC AACTTCGGCGGGCAGAGTGAGCAGGAGAACACGCTCAACCAGCTGCTTGTGGAGATGGAC GGATTTAACACAACAACCAATGTGGTCATCTTGGCGGGCACCAACCGACCGGATATCCTA GACCCAGCTCTGATGAGGCCAGGCCGCTTCGACAGGCAGATCTTCATTGGACCGCCGGAC ATTAAGGGAAGAGCCTCTATTTTCAAAGTTCATCTCCGACCCCTGAAGCTGGATAGCACC CTGGAAAAGGAGAAGCTGGCGAGGAAGCTCGCATCCTTGACCCCGGGGTTTTCAGGAGCC GATGTTGCCAACGTGTGCAACGAAGCTGCTTTGATCGCTGCGAGACACCTTTCAGATTCC ATAAACCAGAAACACTTTGAACAAGCAATTGAACGAGTGATTGGCGGCTTAGAGAAGAAA ACGCAGGTCCTACAGCCTGAGGAGAAGAAGACAGTGGCATACCATGAGGCAGGCCACGCA GTTGCCGGTTGGTACCTGGAGCACGCAGACCCCCTCTTGAAGGTGTCCATCATCCCACGA GGCAAAGGGCTGGGCTACGCTCAGTACCTGCCCCGGGAGCAGTACCTCTACACCCGGGAG CAGCTCCTGGACCGCATGTGCATGACCTTGGGCGGCCGCGTGTCCGAGGAGATCTTCTTT GGCAGGATCACTACCGGTGCCCAGGACGACTTGCGCAAAGTGACCCAGAGTGCCTACGCC CAGATTGTTCAGTTTGGCATGAACGAGAAGGTCGGGCAGATCTCCTTTGACCTCCCACGT CAGGGGGACATGGTGTTGGAGAAGCCGTACAGCGAGGCCACCGCCAGACTCATAGATGAC GAAGTACGAATCCTTATCAACGATGCTTACAAGAGGACAGTGGCCCTCCTCACAGAGAAG AAAGCTGACGTGGAGAAGGTTGCTCTGCTGTTGTTAGAAAAAGAAGTGTTAGACAAGAAC GACATGGTGGAACTTCTGGGCCCCAGGCCATTTGCGGAGAAGTCTACGTACGAGGAGTTT GTGGAAGGCACTGGTAGCCTAGACGAGGACACCTCACTCCCCGAGGGCCTGAAGGACTGG AACAGGGAGCGTGAGGGCTCAGAGGAGCCCTCGGGCGAGAAGGTGACCAGCCCGGTCCAG GGTGCCGGCCCTGCGTAG |
| Protein Properties | |
| Number of Residues | 805 |
| Molecular Weight | 89388.0 |
| Theoretical pI | 9.05 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>AFG3-like protein 2 MAHRCLLLWGRGACRPRGMPPMLLPGGRTGSTERLYLRMLYRYATTQAKTSRNSLLTDVI AAYQRLCSRPPKGFEKYFPNGKNGKKTSEPKEVMGEKKEPKPAAAPRPSGGGVGGGGKRG GKKDDSHWWSRFQKGDIPWDDKEFKMYFLWTALFWGGFLFYFLFKSSGREITWKDFANNY LSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGEN RVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVL KDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAK ATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRG NFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALMRPGRFDRQIFIGPPD IKGRASIFKVHLRPLKLDSTLEKEKLARKLASLTPGFSGADVANVCNEAALIAARHLSDS INQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPR GKGLGYAQYLPREQYLYTREQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYA QIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEK KADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDW NREREGSEEPSGEKVTSPVQGAGPA |
| External Links | |
| GenBank ID Protein | AAI05323.1 |
| UniProtKB/Swiss-Prot ID | Q2KJI7 |
| UniProtKB/Swiss-Prot Entry Name | AFG32_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC105322 |
| GeneCard ID | AFG3L2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |