Showing Protein DNA topoisomerase (BMDBP01051)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01051 |
| Secondary Accession Numbers | None |
| Name | DNA topoisomerase |
| Synonyms | Not Available |
| Gene Name | TOP3A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Replication, recombination and repair |
| Specific Function | Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | TOP3A |
| Gene Sequence |
>3009 bp ATGATATTTCCGGCCGCCCACCGCGCTCTCCGGGGGCTGCCGCGGCCCGGTACTCGGGCC CTGACTCGCGCCGCCATGGAGGTGGCCCTGCGAGGCGTGCGGAAAATCCTTTGCGTGGCC GAGAAGAACGACGCGGCCAAGGGCATAGCCGACTTGCTGTCTGGCGGCCGCATGCGGCGG AGGGAAGGACTTTCAAGATTCAACAAGATCTATGAGTTTGATTATCATCTGTGTGGCCAG AATGTCACCATGGTAATGACCTCAGTCTCAGGACACTTGCTGGCCCATGATTTCCGGATG CAGTTTCGCAAATGGCAGAGCTGCAATCCTCTTGTCCTGTTTGAAGCAGAAATTGAAAAG TACTGCCCAGAGAATTTTGTAGACATCAAGAAAACTCTGGAGCGAGAGGCCCAGCAATGC CAGGCCCTGGTGATTTGGACCGACTGCGACAGAGAGGGTGAAAACATTGGGTTTGAGGTC ATCCACGTGTGCAAGGCCGTGAAGCCCAGCCTGCAGGTGCTGCGAGCCCGTTTCTCCGAG ATCACCACCCGCGCTGTCCGGACGGCATGTGAAAACCTTACGGAGCCCGACCAGAGAGTG AGCGATGCCGTGGATGTGAGGCAGGAGTTGGACCTGCGGATCGGGGCGGCCTTCACCAGG TTCCAGACGCTGCGGCTGCAGAAGATCTTCCCCGAGGTGCTGGCAGAGCAGCTTATCAGC TACGGCAGCTGCCAGTTCCCCACCCTGGGGTTCGTGGTGGAGAGGTTCAAAGCCATTCAG GCATTTGTGCCAGAAGTCTTCCACAAGATCCGAGTGACTCATGACCACAGGGACGGCGTG GTAGAGTTCAGCTGGAAAAGGCATCGTCTCTTCAATCACACGGCATGTCTCGTCCTCTAC CAGATGTGCATGGAGGATCCCAGGGCGATGGTGGTAGAGGTCAGGTCAAAAGCCAAGAGC AAGTGGAGGCCTCAGGCTCTGGACACTGTGGAGCTGGAGAAGCTGGCATCTCGGAAGTTG AGGATAAATGCTAAAGAAACCATGAGGATTGCAGAAAAGCTCTACACCCAAGGGTACATC AGCTATCCTCGAACTGAAACGAACATTTTCCCCAAAGACCTAGACCTGGCGGCACTGGTG GAGCAACAGACCCCGGATCCACGCTGGGGGGCCTTTGCTCGAAACATTCTAGAGCGCGGT GGCCCCACCCCACGCAATGGGAATAAGTCTGACCAAGCGCACCCTCCCATCCACCCCACC AAATACACTGACAGCCTGCAGGGGGATGAGCAGCGACTGTACGAGCTCATCGTCCGCCAC TTCCTGGCCTGCTGCTCGCAGGATGCCCAGGGCCAGGAGACCACTGTGGAGATCGACATC GCGCAGGAGCGCTTCGTGGCCCACGGCCTCATGATCCTGGCCCGGAACTATCTGGACGTG TACCCGTATGATCGCTGGAGTGACAAGACCCTCCCTGTCTATGAGCAAGGCACCTGCTTT CAGCCCAGCACTGTGGAGATGGTGGACGGGGAGACCAGTCCCCCCCAGCTGCTCACCGAG GCTGACCTCATTGCCCTCATGGAGAAGCACGGCATTGGTACGGACGCCACGCACGCTGAG CACATCGAGACCATCAAGGCCCGGATGTACGTCGGGCTCACGCCAGATAAGCGCTTTCTC CCTGGGCACCTGGGCATGGGGCTCGTGGAAGGCTATGACTCCATGGGCTACGAGATGTCC AAGCCTGATCTGCGGGCCGAGCTGGAGGCTGACCTGAAGCTCATCTGCGAGGGGAAGAAG GACAAGCTGGTGGTCCTGCATCAGCAGGTGCAGAAGTACAAGCAGGTGTTCATCGAAGCC GTGGCCAAAGCCAGGAAGTTGGACGAGGCCTTGTCCCAGTACTTCGGGGCGGCTACAGAG GTAGCCCCACAGGACGCCCTCCCGGCTGTGCCCGAGCCCATCAGGAAGTGTCCTCAGTGC AGCCGGGACATGGTTCTTAAGACCAGAAAGAGTGGCGGGTTTTACCTCGGTTGCACGGGC TTCCCTGAGTGTCGGTCGGCTGTCTGGTTCCCGGACAGCGTGCTGGAGGCCAGCAGGGAT GTGAGCGTGTGCCCAGTGTGCCAGCCGCACCCAGTTTACAGGTTGAAGTTCAAGTTTAAA CGAGGCAGCCTGCCCCCAACCATGCCCCTAGAATTTGTCGGCTGCATCGGCGGGTGTGAT GAGACCCTGAGGGAGATCCTGGCCCTCAGGTTCTCCCAGGGCGCTGCCCGAGTCAGCCAG CCTGCCAGCCAGACCTCCGGCTACCTGCAGGCTAGCCAGTCCCTGAACAGAATGGACAGT GGCCAGCAGGGCCAGCCCCGGCCCCCCGTCACCAGGCCCTCGAAGGCTTTGACCAGGACT CTTCCTCCACCCGCCGTTGAGAGTGAGAGCAACTCGGTGACCTGCAACTGTGGCCAGGAG GCCCTGCTGCTCACCGTCCGGAAGGAGGGCCCCAACCAGGGCCGCCAGTTCTACAAGTGT GGCAGTGGTGGCTGCAGCTTCTTTCTATGGGCTGACAGCGGCCACCCAGGAGCCGGGCCT CCCTCCTCAGCGTCCAGACCCCCAGGCGGCCCCCTGGAACACCCCCCGGGCTCAGGGACT CTCTTGGGCGGGTCCAGCAGGCCTGGCAGTGGTGGCAGCGGTGGCGCATCCTGCCTGTGT GGCCAGCCGGCTGTCACGCGCACCGTGCAGAAGGAGGGGCCCAACCAGGGCCGCCAGTTC CACACGTGTGCCCAGCCCCGTGAGCACCAGTGCGGCTTCTTCCAGTGGGTGGACGAGAAC GTGGCCCCAGGGACCTTCGGAGGCCCCCTCTGGCCAGGAAGCAGGAGAGGAACCCAGGGG CTGGAGGCCAGAAGCAAGAGGCCTCGGGCCGGCTCCTCAGACACAGGGTCTGCAACCAAG AAACCCCGGAAGTGCAGCCTTTGCCACCAGCCTGGACATACCCGTCCCTTCTGTCCTCAG AACAGATGA |
| Protein Properties | |
| Number of Residues | 1002 |
| Molecular Weight | 111512.0 |
| Theoretical pI | 8.59 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>DNA topoisomerase MIFPAAHRALRGLPRPGTRALTRAAMEVALRGVRKILCVAEKNDAAKGIADLLSGGRMRR REGLSRFNKIYEFDYHLCGQNVTMVMTSVSGHLLAHDFRMQFRKWQSCNPLVLFEAEIEK YCPENFVDIKKTLEREAQQCQALVIWTDCDREGENIGFEVIHVCKAVKPSLQVLRARFSE ITTRAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKIFPEVLAEQLIS YGSCQFPTLGFVVERFKAIQAFVPEVFHKIRVTHDHRDGVVEFSWKRHRLFNHTACLVLY QMCMEDPRAMVVEVRSKAKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYI SYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGPTPRNGNKSDQAHPPIHPT KYTDSLQGDEQRLYELIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDV YPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAE HIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKK DKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAATEVAPQDALPAVPEPIRKCPQC SRDMVLKTRKSGGFYLGCTGFPECRSAVWFPDSVLEASRDVSVCPVCQPHPVYRLKFKFK RGSLPPTMPLEFVGCIGGCDETLREILALRFSQGAARVSQPASQTSGYLQASQSLNRMDS GQQGQPRPPVTRPSKALTRTLPPPAVESESNSVTCNCGQEALLLTVRKEGPNQGRQFYKC GSGGCSFFLWADSGHPGAGPPSSASRPPGGPLEHPPGSGTLLGGSSRPGSGGSGGASCLC GQPAVTRTVQKEGPNQGRQFHTCAQPREHQCGFFQWVDENVAPGTFGGPLWPGSRRGTQG LEARSKRPRAGSSDTGSATKKPRKCSLCHQPGHTRPFCPQNR |
| External Links | |
| GenBank ID Protein | AAI26548.1 |
| UniProtKB/Swiss-Prot ID | A0JN73 |
| UniProtKB/Swiss-Prot Entry Name | A0JN73_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC126547 |
| GeneCard ID | TOP3A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |