You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Bovine Metabolome Database.
Identification |
BMDB Protein ID
| BMDBP01057 |
Secondary Accession Numbers
| |
Name
| Betaine--homocysteine S-methyltransferase 1 |
Synonyms
|
Not Available
|
Gene Name
| BHMT |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Amino acid transport and metabolism |
Specific Function
| Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). |
Pathways
|
- Amine and polyamine degradation
- Amino-acid biosynthesis
- Betaine degradation
- L-methionine biosynthesis via de novo pathway
- L-methionine from L-homocysteine (BhmT route): step 1/1
- Sarcosine from betaine: step 1/2.
|
Reactions
|
Betaine + Homocysteine → Dimethylglycine + L-Methionine |
details
|
L-Cystathionine → Homocysteine |
details
|
|
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 10 |
Locus
| Not Available |
SNPs
| BHMT |
Gene Sequence
|
>1224 bp
ATGGCACCGGCTGGGGGCAAAAATGTCAAGAAGGGCATCCTAGAACGGCTAAACTCTGGA
GAGGTCATCATCGGAGACGGAGGGTTTGTCTTTGCGCTGGAGAAGAGGGGCTACGTGAAG
GCAGGGCCCTGGACCCCAGAAGCTGCTGTGGAACACCCAGAAGCAGTTCGCCAACTTCAT
CGAGAGTTCCTCAGAGCTGGCTCGAATGTCATGCAGACCTTCACCTTCTATGCCAGTGAA
GACAAGCTGGAGAACAGGGGGAACTATGTTGCAGAGAAAATATCCGGGCAGAAAGTCAAT
GAAGCCGCTTGTGACATTGCCCGGCAAGTGGCTGATGAAGGAGATGCTTTGGTAGCAGGG
GGTGTGAGCCAGACACCTTCGTACCTTAGCTGCAAGAGCGAAACTGAAGTCAAAAAAGTC
TTTCAGCAACAGTTAGAGGTCTTCGTAAAGAAGAACGTGGACTTCTTGATCGCAGAGTAT
TTTGAACATGTTGAAGAGGCTGTATGGGCAGTTGAAGCCTTGAAAGCATCAGGGAAACCA
GTGGCGGCAACTATGTGCATCGGCCCAGAGGGAGACTTGCACAGCGTGACCCCTGGCGAG
TGTGCAGTGCGCCTGGTTAAAGCAGGAGCTTCCATCGTGGGGGTAAACTGCCATTTTGAC
CCCACAATTAGCTTACAGACAGTGAAGCTCATGAAAGAAGGCTTGGAGGCTGCCGGACTG
AAAGCCCACCTCATGAGCCAGCCCTTGGCCTACCACACTCCTGACTGCGGCAAGCAGGGG
TTTATTGACCTGCCAGAATTCCCCTTTGGACTGGAACCCAGAGTTGCAACCAGATGGGAT
ATTCAAAAGTATGCCAGAGAGGCCTACAACCTGGGGGTCAGGTACATAGGTGGGTGCTGT
GGATTTGAACCCTACCACATCAGGGCAATTGCAGAGGAGCTGGCTCCGGAGAGGGGATTT
TTGCCACTGGCTTCAGAAAAACATGGCAGCTGGGGAAGTGGTTTGGATATGCACACCAAA
CCCTGGATTAGAGCCAGGGCCAGGAAGGAATACTGGGAGAATCTTCAGATAGCCTCGGGC
AGGCCGTACAACCCTTCCATGTCAAAGCCGGACGCCTGGGGAGTGACCAAAGGAACAGCC
GAGCTTATGCAGCAGAAGGAAGCCACAACGGAGCAGCAGCTGAGAGAGCTCTTCGAAAAA
CAGAAGTTCAAGTCTGCACAGTAG
|
Protein Properties |
Number of Residues
| 407 |
Molecular Weight
| 44878.0 |
Theoretical pI
| 6.84 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Betaine--homocysteine S-methyltransferase 1
MAPAGGKNVKKGILERLNSGEVIIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
REFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAG
GVSQTPSYLSCKSETEVKKVFQQQLEVFVKKNVDFLIAEYFEHVEEAVWAVEALKASGKP
VAATMCIGPEGDLHSVTPGECAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLEAAGL
KAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
GFEPYHIRAIAEELAPERGFLPLASEKHGSWGSGLDMHTKPWIRARARKEYWENLQIASG
RPYNPSMSKPDAWGVTKGTAELMQQKEATTEQQLRELFEKQKFKSAQ
|
External Links |
GenBank ID Protein
| AAW39034.1 |
UniProtKB/Swiss-Prot ID
| Q5I597 |
UniProtKB/Swiss-Prot Entry Name
| BHMT1_BOVIN |
PDB IDs
|
|
GenBank Gene ID
| AY854632 |
GeneCard ID
| BHMT |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |