| Identification |
|---|
| BMDB Protein ID
| BMDBP01058 |
| Secondary Accession Numbers
| |
| Name
| Aminopeptidase N |
| Synonyms
|
Not Available
|
| Gene Name
| ANPEP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| ANPEP |
| Gene Sequence
|
>2898 bp
ATGGCCAAAGGATTCTACATTTCCAAGGCCCTGGGCATCCTGGCCATTCTCCTGGGCGTG
GCGGCCGTGGCCACCATCATCGCTCTGTCTGTGGTGTACGCCCAGGAGAAGAACAAGAAT
GCCGAGCGTGGCACCGCGGCCCCCACGAGCCCCACAGGCCCGACAACCACCTCGGCCACC
ACCTTGGACCAGAGCAAGCCGTGGAACCGATACCGCCTCCCCACGACCCTCTTGCCCGAC
TCCTATAGGGTGACGCTGAGGCCCTACCTCACTCCCAACAATAACGGCCTGTATATCTTC
ACGGGCTCAAGCACTGTCCGCTTCACCTGCAAGGAGCCCACGGACGTCATCATCATCCAC
AGCAAGAAGCTCAACTACACCCAGCACAGTGGGCACTTGGCGGCCCTGAAGGGTGTGGGG
GACACCCAGGCCCCCGAAATCGACAGGACCGAGCTGGTGTTGCTCACAGAGTACCTGGTG
GTGCACCTCAAGAGCTCCCTGGAAGCAGGCAAGACATACGAGATGGAGACCACCTTTCAG
GGGGAGCTGGCCGATGACCTGGCGGGCTTCTACCGCAGCGAGTACATGGACGGCAACGTC
AAAAAGGTCCTGGCCACCACACAGATGCAGTCAACAGATGCCCGGAAGTCCTTCCCCTGC
TTTGACGAGCCCGCCATGAAGGCCACATTTAACATCACCCTCATCCACCCCAAGGATCTC
ACAGCCCTGTCCAACATGCCACCCAAAGGTCCCAGTGTCCCGTTTGACGGAGATTCCAAC
TGGAGCGTCACTGAGTTTGAAACCACGCCGGTAATGTCCACGTACCTCCTGGCCTACATC
GTGAGCGAGTTCACGAGTGTGGAGTCAGTGGCTCCCAATGATGTCCAGATCCGGATCTGG
GCTCGGCCAAAAGCAACTGCAGACAACCATGGCCTTTACGCCCTGAATGTGACAGGTCCC
ATCCTGAACTTCTTTGCCAATCATTACAATACAGCCTACCCACTCCCCAAATCTGACCAG
ATTGCCCTGCCCGACTTCAACGCCGGTGCCATGGAGAACTGGGGGCTGGTGACCTACCGG
GAGAACGCGCTGCTCTATGACCCTCAGTCTTCCTCCAGCAGCAACAAAGAGCGAGTAGTC
ACTGTGATTGCTCATGAGCTGGCCCACCAGTGGTTTGGGAACCTGGTGACCCTGGCCTGG
TGGAATGACCTGTGGCTGAACGAGGGCTTTGCCTCCTATGTGGAGTACCTGGGAGCTGAC
TATGCAGAGCCCACCTGGAATCTGAAAGACCTCATGGTGCCGAATGACGTGTACAGTGTG
ATGGCCGTGGACGCGCTGGTCACCTCTCACCCACTGACCACCCCTGCCAACGAGGTCAAC
ACCCCTGCCCAGATCAGCGAGATGTTCGATACCATCTCCTACAGCAAGGGAGCCTCGGTC
ATCCGGATGCTCTCGAATTTCCTGACTGAGGACCTGTTCAAGAAGGGCCTGGCGTCCTAC
TTGCAGACCTTTGCCTATCAGAACACCACCTACCTGAACCTGTGGGAGCACCTGCAGATG
GCTGTGGAAAATCAGTTGTCCATCAGGCTGCCAGACACCGTGAGTGCCATCATGGACCGC
TGGACCCTACAGATGGGCTTCCCTGTCATCACCGTGGATACTAACACAGGGACCATCTCC
CAGAAGCACTTCCTCCTTGATCCCAACTCCACCGTCACCCGCCCCTCACAGTTCAACTAT
CTGTGGATTGTTCCCATCTCATCCATCAGAAATGGCCAGCCGCAAGAACACTACTGGCTT
CGGGGCGAAGAGAGAAACCAGAATGAACTCTTCAAAGCCGCAGCAGACGACTGGGTCCTG
CTGAACATCAACGTGACGGGCTATTACCAGGTGAACTACGACGAGAACAACTGGAAGAAG
ATTCAGAATCAGCTGATGTCAAGGCGGGAGAACATCCCTGTCATCAACCGGGCACAGGTC
ATCTACGACAGCTTCAACCTGGCCAGTGCCCACATGGTCCCTGTCACCCTGGCGCTGAAC
AACACCCTCTTCCTGAAAAATGAGATGGAGTACATGCCCTGGCAGGCCGCCGTGAGCAGC
CTGAACTACTTCAAGCTCATGTTCGACCGCACAGAGGTCTATGGCCCCATGCAGAATTAC
CTCAAGAACCAGGTTGAACCCATCTTCCTATATTTTGAAAATCTCACCAAAAACTGGACT
GAGATCCCGGAAAACCTGATGGACCAATACAGCGAGATTAACGCCATCAGCACTGCCTGC
TCCAATGGGTTGCCTAAGTGTGAGGAGCTGGCCAAAACACTTTTCAACCAGTGGATGAAT
AACCCTAACGTTAACCCGATCGACCCCAACCTGCGGTCCACCATCTACTGCAACGCCATC
GCCCAGGGTGGCCAGGAAGAGTGGGACTTTGCTTGGAATCAGTTACAACAAGCAGAGCTG
GTTAATGAAGCTGACAAACTCCGCTCAGCGCTGGCCTGCACCAACCACGTCTGGCTCCTG
AACAGGTACCTGAGTTACACCCTGAACCCCGACCTCATCCGGAAGCAGGACGCCACCTCC
ACCATTACCAGCATTGCCAGCAATGTCATCGGGCAGTCTCTGGCCTGGGACTTCATCCGG
AGCAACTGGAAGAAACTCTTTGAGGATTATGGTGGTGGTTCCTTTTCCTTCTCCAACCTC
ATCCAGGGTGTGACCCGAAGATTCTCCACTGAGTTTGAGCTCCAGCAGCTGGAGGAGTTC
AAGGAGAACAACATGGACGTCGGCTTCGGCTCAGGAACACGGGCTCTGGAGCAAGCCCTG
GAGAAGACTAAAGCCAACATCAACTGGGTGAAGGAGAACAAGGAGGTGGTGCTAAACTGG
TTCAAAGACCACAGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 965 |
| Molecular Weight
| 109276.0 |
| Theoretical pI
| 4.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Aminopeptidase N
MAKGFYISKALGILAILLGVAAVATIIALSVVYAQEKNKNAERGTAAPTSPTGPTTTSAT
TLDQSKPWNRYRLPTTLLPDSYRVTLRPYLTPNNNGLYIFTGSSTVRFTCKEPTDVIIIH
SKKLNYTQHSGHLAALKGVGDTQAPEIDRTELVLLTEYLVVHLKSSLEAGKTYEMETTFQ
GELADDLAGFYRSEYMDGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPKDL
TALSNMPPKGPSVPFDGDSNWSVTEFETTPVMSTYLLAYIVSEFTSVESVAPNDVQIRIW
ARPKATADNHGLYALNVTGPILNFFANHYNTAYPLPKSDQIALPDFNAGAMENWGLVTYR
ENALLYDPQSSSSSNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGAD
YAEPTWNLKDLMVPNDVYSVMAVDALVTSHPLTTPANEVNTPAQISEMFDTISYSKGASV
IRMLSNFLTEDLFKKGLASYLQTFAYQNTTYLNLWEHLQMAVENQLSIRLPDTVSAIMDR
WTLQMGFPVITVDTNTGTISQKHFLLDPNSTVTRPSQFNYLWIVPISSIRNGQPQEHYWL
RGEERNQNELFKAAADDWVLLNINVTGYYQVNYDENNWKKIQNQLMSRRENIPVINRAQV
IYDSFNLASAHMVPVTLALNNTLFLKNEMEYMPWQAAVSSLNYFKLMFDRTEVYGPMQNY
LKNQVEPIFLYFENLTKNWTEIPENLMDQYSEINAISTACSNGLPKCEELAKTLFNQWMN
NPNVNPIDPNLRSTIYCNAIAQGGQEEWDFAWNQLQQAELVNEADKLRSALACTNHVWLL
NRYLSYTLNPDLIRKQDATSTITSIASNVIGQSLAWDFIRSNWKKLFEDYGGGSFSFSNL
IQGVTRRFSTEFELQQLEEFKENNMDVGFGSGTRALEQALEKTKANINWVKENKEVVLNW
FKDHS
|
| External Links |
|---|
| GenBank ID Protein
| AAI05143.1 |
| UniProtKB/Swiss-Prot ID
| P79098 |
| UniProtKB/Swiss-Prot Entry Name
| AMPN_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105142 |
| GeneCard ID
| ANPEP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
