| Identification |
|---|
| BMDB Protein ID
| BMDBP01064 |
| Secondary Accession Numbers
| None |
| Name
| Diacylglycerol kinase alpha |
| Synonyms
|
Not Available
|
| Gene Name
| DGKA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. |
| Pathways
|
- Glycerolipid Metabolism
- Phospholipid Biosynthesis
|
| Reactions
|
| DG(16:0/16:0/0:0) → PA(16:0/16:0) |
details
|
| DG(16:0/16:0/0:0) + Adenosine triphosphate → PA(16:0/16:0) + ADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| DGKA |
| Gene Sequence
|
>2205 bp
ATGGCCAAGGAGAGGGGCCTAATAAGCCCCAGTGATTTTGCCCAGCTGCAAAAATACATG
GAATACTCCACCAAAAAGGTCAGTGATGTTCTGAAGCTCTTTGAGGATGGTGAAATGGCT
GAATATCTCCAAGGAGATGCCATTGGATACGAGGGGTTCCAGCAATTCCTGAAAATCTAC
CTGGAGGTGGATAATGTTCCAGATCACCTAAGCCAGGCACTGTTTCAGTCCTTCCAGACT
GGCTACTACATAGAAGACACTGTAAGAGAAGATGTGGTGTGTCTCAGTGATGTCTCCTGC
TACTTTTCTCTTCTGGAGGGTGGCCGGCCAGAAGACAAGCTAGAATTCACCTTCAAGCTG
TACGACACGGACAGAAATGGGATCCTGGACAGCTCAGAAGTGGACAGGATCATCATACAG
ATGATGCGAATGGCTGAATACCTGGATTGGGATGTGTCTGAGCTGAGGCCGATTCTTCAA
GAGATGATGAAAGAGATTGACTATGATGGCAGTGGCTCTGTGTCCCTGGCTGAGTGGCTC
CGGGCTGGGGCCACCACCGTGCCACTGCTCGTGCTGCTGGGCCTGGAGATGACCCTGAAG
GACAATGGGCAGCACATGTGGAGACCCAAGAGATTCCCCCGACCAGTCTACTGCAACCTG
TGCGAGTCGAGCATTGGTCTTGGCAAACAGGGGCTGAGCTGTAACCTCTGTAAATACATC
GTTCACGACCAATGTGCCATGAAGGCCCTGCCCTGTGAAGTCAGCACCTATGCCAAGTCT
CGGAAGGACATTGGTGTCCAATCACACGTGTGGGTGCGAGGAGGCTGTGAATCTGGACGG
TGTGACCGCTGTCAGAAAAAGATCCGGATCTACCACAGTCTGGTTGGGCTGCATTGTGTG
TGGTGCCACCTAGAGATCCATGATGACTGCCTTCCAGCCATGGGCCATGAGTGTGACTGT
GGGCTGCTCCGAGATCACATCCTGCCTCCGTCTTCCATCTATCCCAGCGTCCTGGCCTCT
GGACAGGAGCGTAAAACTAGCAAAATAAGCCAGAAGACCATGGATGATTTAAGTTTGAGC
ACTTCTGAGGCTCTGCGGATTGATCCTGTTTCTAACACCCACCCACTTCTGGTCTTTGTG
AACCCCAAGAGTGGCGGGAAGCAAGGCGAGAGGGTGCTTTGGAAATTCCAGTATCTGCTG
AACCCTCGACAGGTGTTCAACCTCCTAAAGGATGGTCCTGAGCCAGGACTCAGATTCTTC
AGAGATGTTCCTGATTACAGGATTTTGGTGTGCGGCGGAGATGGCACAGTAGGCTGGATT
CTAGAGTCCATTGACAAAGCCAACTTGCCTTTTGTGCCTCCTGTCGCTGTGTTGCCCCTG
GGCACTGGAAATGATCTGGCTCGTTGCCTAAGATGGGGAGGAGGGTATGAGGGACAGAAT
CTGGGGAAGATCCTCAAGGATTTAGAGACAAGTAAGGTGGTACATATGGATCGATGGTCT
GTGGAGGTGATACCCCAACAAACTGAAGAAAAGAGTGACCCAGTCCCCTTTCAAATCATC
AATAACTACTTCTCCATCGGTGTGGATGCCTCTATTGCTCACCGATTCCACATTATGCGA
GAGAAATATCCTGAGAAGTTCAACAGCAGAATGAAGAACAAGCTATGGTACTTCGAATTT
GCCACTTCTGAATCCATCTTCTCAACGTGCAAAAAGCTGGAGGAATCTTTGACAGTTGAG
ATCTGTGGGAAACCACTGGATCTGAGCAACCTGTCCCTAGAAGGCATTGCAGTGCTGAAC
ATCCCAAGCACACATGGTGGCTCCAATCTCTGGGGTGACACCAAGAGACCACATGGCGAT
ATCCATGGGATCAACCAGGCCTTAGGTGCTACTGCCAAAGTCATCACCGACCCTGATATC
CTGAAGACCTGTGTACCAGACCTAAGTGACAAGCGGCTGGAAGTAGTGGGGCTGGAGGGT
GCAATTGAGATAGGCCAGATCTATACCAAGCTCAAGAATGCTGGACATCGGCTGGCCAAG
TGCTCTGAGATCACCTTCCACACCACAAAAACCCTCCCCATGCAAATTGACGGAGAACCC
TGGATGCAGACACCTTGTACAATCAAGATCACCCACAGGAACCAGATGCCTATGCTCGTG
GGCCCACCCCCTCGCTCCTCCAATTTTTTTGGCTTCTTGTGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 734 |
| Molecular Weight
| 82672.0 |
| Theoretical pI
| 6.27 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Diacylglycerol kinase alpha
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAEYLQGDAIGYEGFQQFLKIY
LEVDNVPDHLSQALFQSFQTGYYIEDTVREDVVCLSDVSCYFSLLEGGRPEDKLEFTFKL
YDTDRNGILDSSEVDRIIIQMMRMAEYLDWDVSELRPILQEMMKEIDYDGSGSVSLAEWL
RAGATTVPLLVLLGLEMTLKDNGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYI
VHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLVGLHCV
WCHLEIHDDCLPAMGHECDCGLLRDHILPPSSIYPSVLASGQERKTSKISQKTMDDLSLS
TSEALRIDPVSNTHPLLVFVNPKSGGKQGERVLWKFQYLLNPRQVFNLLKDGPEPGLRFF
RDVPDYRILVCGGDGTVGWILESIDKANLPFVPPVAVLPLGTGNDLARCLRWGGGYEGQN
LGKILKDLETSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMR
EKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLN
IPSTHGGSNLWGDTKRPHGDIHGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEG
AIEIGQIYTKLKNAGHRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHRNQMPMLV
GPPPRSSNFFGFLC
|
| External Links |
|---|
| GenBank ID Protein
| AAI26522.1 |
| UniProtKB/Swiss-Prot ID
| A0JN54 |
| UniProtKB/Swiss-Prot Entry Name
| DGKA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126521 |
| GeneCard ID
| DGKA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
