| Identification |
|---|
| BMDB Protein ID
| BMDBP01072 |
| Secondary Accession Numbers
| |
| Name
| D-3-phosphoglycerate dehydrogenase |
| Synonyms
|
Not Available
|
| Gene Name
| PHGDH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. |
| Pathways
|
- Amino-acid biosynthesis
- L-serine biosynthesis
- L-serine from 3-phospho-D-glycerate: step 1/3
|
| Reactions
|
| 3-Phosphoglyceric acid + NAD → Phosphohydroxypyruvic acid + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| PHGDH |
| Gene Sequence
|
>1602 bp
ATGGCCTTTGCAAATCTACGGAAAGTGCTTATCAGTGATAGCCTGGACCCTTGCTGCCGG
AAGATCCTGCAAGACGGAGGGCTGCAGGTGGTGGAGAAGCAGAACCTGAGCAAAGAGGAG
CTGATAGCCGAGCTGCAGGACTGTGAAGGCCTTATTGTCCGCTCGGCCACCAAGGTGACC
TCTGACATCATCAACGCGGCAGAGAAGCTGCAGGTGGTGGGCAGGGCTGGCACAGGCGTG
GACAACGTGGATCTGGAGGCCGCAACCAGAAAGGGCATCCTGGTCATGAATACCCCCAAT
GGGAACAGCCTCAGTGCTGCAGAGCTCACCTGTGGAATGATCATGTGTCTCGCCAGGCAG
ATTCCTCAGGCGGCGGCATCTATGAAGGATGGCAAGTGGGAGCGGAAGAAGTTCATGGGA
ACCGAGCTGAATGGAAAGGTCCTAGGAATTCTTGGCTTGGGCAGAATCGGGAGAGAAGTG
GCCACCCGGATGCAGTCCTTTGGGATGAAGACCATAGGCTACGACCCCATCATCTCGCCA
GAGGTCTCGGCCTCCTTCGGTGTGCAGCAGCTGCCCCTGGAGCAGATCTGGCCTCTCTGT
GACTTTATCACTGTGCACACACCTCTCCTGCCCTCCACCACAGGCCTGCTGAACGACAGC
ACCTTTGCCCAGTGCAAGAAGGGGGTGTGCGTGGTGAACTGTGCTCGAGGAGGGATCGTG
GACGAAGGTGCCCTGCTCCGGGCCCTGCAGTCGGGTCAGTGTGCTGGCGCTGCACTGGAC
GTGTTCACGGAGGAACCACCCCGGGACCGGGCCTTGGTGAACCATGAGAATGTCATCAGC
TGCCCCCACCTGGGCGCCAGCACCAAGGAGGCTCAGAGTCGCTGCGGGGAGGAGATCGCC
CTCCAGTTTGTGGACATGGTGAAGGGGAAGGCCCTGGCGGGGGTTGTAAATGCCCAGGCC
CTTGCCAGCATCTTCTGTCCACACACCAAGCCTTGGGTCAGTCTGGCTAAAGCTCTTGGG
GCGCTGATGCAGGCCTGGGCTGGGTCTCCCAAAGGGGCCATCCAGGTGGTGACACAGGGA
TCATCCCTGAAGAACTCCGGGAGCTGCCTGGCCCCTGCCGTCATCATCGGCCTCCTGAAG
GACGCGTCCCAGCAGTCGAATGTGAACCTGGTGAACGCCATGCTGCTGGTGAAAGAGGCC
GGCCTCGATGTGACCACCTCCCACAACCCTGCCACACCACGGGAGCAGGACTTTGGGGAA
TGCCTGCTGACCGTGGCCCTGGCAGGTGCCCCCTACCAGGCTGTGGGCTTGGTCCAGGGC
ACCAAGCCTGTGCTGCAGGCGCTCAACGGAGCTGTCTTCAGACCAGAAGTGCCTCTCCAC
CCTGGCCAGCCGCTGCTCATGTTCCGGGCTCAGGCCTCCAACCCTGCGATGCTGCCGACC
ATGATTGGCCTCCTTGCAGAGGCAGGGGTGCAGCTGCTGTCCTACCAGAGCTCCGTGGTG
TCAGATGGGGAGACCTGGCACGTCATGAGTATCTCCTCCCTACTCCCCAGCCTGGCACCC
TGGAAGCCGCACGTGACCGAGGCTTTCCAGTTCTGCTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 533 |
| Molecular Weight
| 56452.0 |
| Theoretical pI
| 6.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>D-3-phosphoglycerate dehydrogenase
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
SDIINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQAAASMKDGKWERKKFMGTELNGKVLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEQIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVCVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVNHENVISCPHLGASTKEAQSRCGEEIA
LQFVDMVKGKALAGVVNAQALASIFCPHTKPWVSLAKALGALMQAWAGSPKGAIQVVTQG
SSLKNSGSCLAPAVIIGLLKDASQQSNVNLVNAMLLVKEAGLDVTTSHNPATPREQDFGE
CLLTVALAGAPYQAVGLVQGTKPVLQALNGAVFRPEVPLHPGQPLLMFRAQASNPAMLPT
MIGLLAEAGVQLLSYQSSVVSDGETWHVMSISSLLPSLAPWKPHVTEAFQFCF
|
| External Links |
|---|
| GenBank ID Protein
| AAX08654.1 |
| UniProtKB/Swiss-Prot ID
| Q5EAD2 |
| UniProtKB/Swiss-Prot Entry Name
| SERA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020637 |
| GeneCard ID
| PHGDH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
