Showing Protein D-3-phosphoglycerate dehydrogenase (BMDBP01072)
| Identification | |||
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| BMDB Protein ID | BMDBP01072 | ||
| Secondary Accession Numbers |
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| Name | D-3-phosphoglycerate dehydrogenase | ||
| Synonyms | Not Available | ||
| Gene Name | PHGDH | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Coenzyme transport and metabolism | ||
| Specific Function | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 3 | ||
| Locus | Not Available | ||
| SNPs | PHGDH | ||
| Gene Sequence |
>1602 bp ATGGCCTTTGCAAATCTACGGAAAGTGCTTATCAGTGATAGCCTGGACCCTTGCTGCCGG AAGATCCTGCAAGACGGAGGGCTGCAGGTGGTGGAGAAGCAGAACCTGAGCAAAGAGGAG CTGATAGCCGAGCTGCAGGACTGTGAAGGCCTTATTGTCCGCTCGGCCACCAAGGTGACC TCTGACATCATCAACGCGGCAGAGAAGCTGCAGGTGGTGGGCAGGGCTGGCACAGGCGTG GACAACGTGGATCTGGAGGCCGCAACCAGAAAGGGCATCCTGGTCATGAATACCCCCAAT GGGAACAGCCTCAGTGCTGCAGAGCTCACCTGTGGAATGATCATGTGTCTCGCCAGGCAG ATTCCTCAGGCGGCGGCATCTATGAAGGATGGCAAGTGGGAGCGGAAGAAGTTCATGGGA ACCGAGCTGAATGGAAAGGTCCTAGGAATTCTTGGCTTGGGCAGAATCGGGAGAGAAGTG GCCACCCGGATGCAGTCCTTTGGGATGAAGACCATAGGCTACGACCCCATCATCTCGCCA GAGGTCTCGGCCTCCTTCGGTGTGCAGCAGCTGCCCCTGGAGCAGATCTGGCCTCTCTGT GACTTTATCACTGTGCACACACCTCTCCTGCCCTCCACCACAGGCCTGCTGAACGACAGC ACCTTTGCCCAGTGCAAGAAGGGGGTGTGCGTGGTGAACTGTGCTCGAGGAGGGATCGTG GACGAAGGTGCCCTGCTCCGGGCCCTGCAGTCGGGTCAGTGTGCTGGCGCTGCACTGGAC GTGTTCACGGAGGAACCACCCCGGGACCGGGCCTTGGTGAACCATGAGAATGTCATCAGC TGCCCCCACCTGGGCGCCAGCACCAAGGAGGCTCAGAGTCGCTGCGGGGAGGAGATCGCC CTCCAGTTTGTGGACATGGTGAAGGGGAAGGCCCTGGCGGGGGTTGTAAATGCCCAGGCC CTTGCCAGCATCTTCTGTCCACACACCAAGCCTTGGGTCAGTCTGGCTAAAGCTCTTGGG GCGCTGATGCAGGCCTGGGCTGGGTCTCCCAAAGGGGCCATCCAGGTGGTGACACAGGGA TCATCCCTGAAGAACTCCGGGAGCTGCCTGGCCCCTGCCGTCATCATCGGCCTCCTGAAG GACGCGTCCCAGCAGTCGAATGTGAACCTGGTGAACGCCATGCTGCTGGTGAAAGAGGCC GGCCTCGATGTGACCACCTCCCACAACCCTGCCACACCACGGGAGCAGGACTTTGGGGAA TGCCTGCTGACCGTGGCCCTGGCAGGTGCCCCCTACCAGGCTGTGGGCTTGGTCCAGGGC ACCAAGCCTGTGCTGCAGGCGCTCAACGGAGCTGTCTTCAGACCAGAAGTGCCTCTCCAC CCTGGCCAGCCGCTGCTCATGTTCCGGGCTCAGGCCTCCAACCCTGCGATGCTGCCGACC ATGATTGGCCTCCTTGCAGAGGCAGGGGTGCAGCTGCTGTCCTACCAGAGCTCCGTGGTG TCAGATGGGGAGACCTGGCACGTCATGAGTATCTCCTCCCTACTCCCCAGCCTGGCACCC TGGAAGCCGCACGTGACCGAGGCTTTCCAGTTCTGCTTCTAA |
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| Protein Properties | |||
| Number of Residues | 533 | ||
| Molecular Weight | 56452.0 | ||
| Theoretical pI | 6.89 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>D-3-phosphoglycerate dehydrogenase MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT SDIINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ IPQAAASMKDGKWERKKFMGTELNGKVLGILGLGRIGREVATRMQSFGMKTIGYDPIISP EVSASFGVQQLPLEQIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVCVVNCARGGIV DEGALLRALQSGQCAGAALDVFTEEPPRDRALVNHENVISCPHLGASTKEAQSRCGEEIA LQFVDMVKGKALAGVVNAQALASIFCPHTKPWVSLAKALGALMQAWAGSPKGAIQVVTQG SSLKNSGSCLAPAVIIGLLKDASQQSNVNLVNAMLLVKEAGLDVTTSHNPATPREQDFGE CLLTVALAGAPYQAVGLVQGTKPVLQALNGAVFRPEVPLHPGQPLLMFRAQASNPAMLPT MIGLLAEAGVQLLSYQSSVVSDGETWHVMSISSLLPSLAPWKPHVTEAFQFCF |
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| External Links | |||
| GenBank ID Protein | AAX08654.1 | ||
| UniProtKB/Swiss-Prot ID | Q5EAD2 | ||
| UniProtKB/Swiss-Prot Entry Name | SERA_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BT020637 | ||
| GeneCard ID | PHGDH | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||