Showing Protein 2-oxoglutarate dehydrogenase, mitochondrial (BMDBP01073)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP01073 | ||
| Secondary Accession Numbers | None | ||
| Name | 2-oxoglutarate dehydrogenase, mitochondrial | ||
| Synonyms | Not Available | ||
| Gene Name | OGDH | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Energy production and conversion | ||
| Specific Function | 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. | ||
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 4 | ||
| Locus | Not Available | ||
| SNPs | OGDH | ||
| Gene Sequence |
>3072 bp ATGTTTCACTTAAGGACTTGTGCTGCTAAGTTGAGGCCGTTAACGGCTTCCCAGACTGTG AAGACATTTTCACAAAACAGACCAGCAGCAGCTAGGACGTTTGGGCAGATACGGTGCTAT ACTGCCCCCGTTGCTGCAGAGCCTTTCCTCAGCGGGACTAGTTCGAACTATGTGGAGGAA ATGTACTATGCTTGGTTGGAAAACCCCAAAAGTGTACACAAGTCATGGGACATTTTTTTC CGAAACACCAATGCTGGAGCGCCCCCAGGCACCGCCTACCAGAGCCCACTCCCCCTGAGC CCGGGCTCCCTGTCAGCTGTGGCCAGAGCAGGGCCCCTGGTGGAGGCCCAGCCCAACGTG GACAAGCTGGTGGAGGATCACCTGGCGGTGCAGTCGCTCATCAGGGCTTACCAGATACGA GGGCACCATGTAGCACAGCTGGACCCCCTGGGAATTTTGGATGCTGATCTGGACTCCTCC GTGCCCGCTGATATTATCTCATCCACAGACAAACTTGGATTCTACGGTCTGGACGAGTCT GACCTGGACAAGGTCTTCCACCTGCCCACCACCACATTCATTGGAGGGCAGGAGTCGGCT CTTCCTCTGCGGGAAATCATCCGACGCCTGGAGATGGCCTACTGCCAGCACATTGGGGTA GAATTCATGTTCATCAATGACCTGGAGCAGTGCCAGTGGATCCGGCAGAAATTTGAGACA CCCGGGGTCATGCAGTTCACCAACGAGGAGAAGCGGACCCTGCTGGCTCGGCTCGTGCGC TCCACCAGGTTTGAGGAGTTCCTGCAGCGGAAGTGGTCATCTGAGAAGCGCTTTGGTCTG GAAGGCTGCGAAGTACTGATTCCTGCCCTCAAGACCATCATTGACAAGTCCAGTGAGAAC GGAGTGGACTACGTGATCATGGGAATGCCACACAGGGGGAGACTGAATGTGCTTGCAAAC GTCATCAGGAAGGAGCTGGAGCAAATTTTCTGTCAGTTCGACTCAAAGCTGGAGGCAGCT GATGAGGGTTCTGGAGATGTGAAGTACCACCTGGGCATGTATCACCGGCGGATCAACCGT GTGACCGACAGGAATATCACCCTGTCGCTGGTGGCAAACCCTTCCCACCTGGAGGCTGCC GATCCCGTGGTGATGGGCAAGACCAAAGCTGAGCAGTTTTACTGCGGGGACACCGAGGGG AAGAAGGTCATGTCCATCCTTCTGCATGGGGACGCCGCATTTGCTGGCCAGGGCATCGTT TATGAGACCTTCCACCTGAGTGACCTGCCATCTTACACGACTCATGGCACTGTCCACGTG GTTGTCAACAACCAGATCGGCTTCACCACAGACCCGCGAATGGCCCGCTCCTCACCCTAC CCCACTGATGTGGCCCGAGTGGTGAATGCCCCTATCTTCCACGTGAACTCGGATGACCCG GAGGCAGTCATGTATGTGTGCAAAGTTGCAGCTGAGTGGAGGAGCACCTTCCACAAGGAT GTGGTGGTGGACCTGGTGTGTTATCGGCGCAATGGCCACAACGAGATGGATGAGCCCATG TTCACCCAGCCGCTGATGTACAAGCAGATCCGCAAACAGAAGCCCGTGCTGCAGAAGTAC GCAGAGTTGCTGGTGTCGCAGGGCGTGGTCAACCAGCCTGAGTATGAGGAGGAGATCTCC AAATATGACAAGATCTGTGAGGAGGCCTTCGCCAGGTCCAAGGACGAAAAGATCTTGCAC ATCAAGCACTGGCTGGACTCCCCCTGGCCTGGCTTCTTCACCCTGGACGGGCAGCCGAGG AGCATGACCTGCCCCTCCACGGGCCTGACGGAGGACATTCTCACACACATTGGGAACGTG GCCAGCTCCGTGCCTGTGGAGGATTTCACCATTCACGGAGGGCTGAGCCGGATCCTGAAG ACCCGTGGGGAGCTGGTGAAGAACAGGACTGTGGACTGGGCTCTGGCGGAGTACATGGCT TTTGGCTCCCTACTGAAGGAGGGCATCCATATCCGGCTGAGCGGCCAGGATGTGGAGCGG GGCACTTTTAGCCATCGCCACCACGTCCTGCATGACCAGAACGTGGACAAGAGAACCTGC ATCCCCATGAACCACCTCTGGCCCAACCAGGCCCCCTACACCGTGTGCAACAGCTCACTG TCCGAGTACGGGGTCCTGGGCTTCGAGCTGGGTTTTGCAATGGCCAGTCCTAACGCCCTG GTCCTCTGGGAGGCCCAGTTTGGTGACTTCCATAACACGGCCCAGTGCATCATCGACCAG TTCATCTGCCCAGGACAAGCCAAGTGGGTGCGGCAGAACGGCATTGTGCTGCTGCTGCCC CATGGCATGGAGGGCATGGGCCCAGAACATTCCTCCGCCAGGCCAGAGAGGTTCCTGCAG ATGTGCAATGATGATCCAGACGTCCTACCGGACCTTAAGGAAGCCAACTTTGACATAAAT CAGCTGTATGATTGCAACTGGGTTGTCGTCAACTGCTCCACCCCTGGCAACTTCTTCCAC GTGCTACGTCGCCAGATTCTCCTGCCCTTCCGGAAGCCGTTAATCATCTTCACCCCAAAG TCCCTGCTGCGGCATCCCGAAGCCAGGTCCAACTTTGACGAGATGCTTCCAGGAACCCAC TTCCAGCGGGTGATCCCAGAAGATGGCCCTGCAGCACAGAACCCAGGAAACGTCAAGAGA CTTCTCTTCTGTACTGGCAAGGTGTACTATGACCTCACCCGAGAGCGCAAAGCGCGGGAC ATGGTGGAGCAGGTGGCCATCACCAGGATCGAGCAGCTGTCGCCTTTCCCCTTCGACCTC CTGCTGCAGGAGGTCCAGAAGTACCCCAGCGCTGAGCTGGCCTGGTGCCAGGAGGAGCAC AAGAACCAAGGCTACTACGACTACGTGAAGCCCAGGCTGCGAACCACCATCAGCCGCGCC AAGCCTGTGTGGTATGCTGGCCGGGACCCAGCAGCAGCTCCAGCCACCGGCAACAAGAAG ACCCACCTCACGGAGCTGCAGCGCCTCCTGGACACAGCCTTCGACCTGGACGCCTTCAAG AACTTCTCGTAG |
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| Protein Properties | |||
| Number of Residues | 1023 | ||
| Molecular Weight | 115808.0 | ||
| Theoretical pI | 6.74 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>2-oxoglutarate dehydrogenase E1 component, mitochondrial MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFGQIRCYTAPVAAEPFLSGTSSNYVEE MYYAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSPGSLSAVARAGPLVEAQPNV DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET PGVMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR SMTCPSTGLTEDILTHIGNVASSVPVEDFTIHGGLSRILKTRGELVKNRTVDWALAEYMA FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH VLRRQILLPFRKPLIIFTPKSLLRHPEARSNFDEMLPGTHFQRVIPEDGPAAQNPGNVKR LLFCTGKVYYDLTRERKARDMVEQVAITRIEQLSPFPFDLLLQEVQKYPSAELAWCQEEH KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDAFK NFS |
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| External Links | |||
| GenBank ID Protein | AAI18107.1 | ||
| UniProtKB/Swiss-Prot ID | Q148N0 | ||
| UniProtKB/Swiss-Prot Entry Name | ODO1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BC118106 | ||
| GeneCard ID | OGDH | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||