| Identification |
|---|
| BMDB Protein ID
| BMDBP01109 |
| Secondary Accession Numbers
| None |
| Name
| Retinal guanylyl cyclase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| GUCY2F |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:9571173, PubMed:9175772). Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:9571173, PubMed:9175772). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| GUCY2F |
| Gene Sequence
|
>3312 bp
ATGTTCTTGGCACCCTGGCCTTTCTCCCACCTTATGCTCTGGTTCGTGACTCTGGGAAGA
CAGCGAGGACAACATGGCCTTGCATCTTTCAAGCTCCTGTGGTGTTTGTGGCTCTTGGTC
CTTATGTCTCTCCCACTACAGGTGTGGGCGCCACCCTACAAGATAGGGGTGGTTGGCCCT
TGGACTTGTGATCCATTGTTCTCAAAGGCCCTGCCTGAGATTGCTGCTCAGTTAGCCACT
GAGCGGATCAACAAGGACCCAGCCTTGGACCTGGGTCACTCTCTTGAATATGTGATTTTC
AATGAAGACTGCCAGGCTTCCAGGGCTCTCTCCAGTTTCATTTCCCACCACCAGATGGCC
TCAGGGTTTATTGGACCTGCCAACCCTGGCTACTGCGAGGCAGCCTCGCTCCTGGGAAAC
AGCTGGGACAAAGGGATTTTCTCCTGGGCTTGCGTGAATTATGAATTAGACAGTAAAAAT
AGCCACCCGACTTTTTCTCGGACCCTCCCTTCTCCCATCCGGGTGCTGCTAACTGTCATG
AAATATTTCCAGTGGGCTCACGCTGGAGTCATTTCCTCAGATGAAGACATTTGGGTGCAC
ACAGCCTATCGAGTTGCAAGTGCTCTTCGGAGCCGCGGCCTGCCAGTAGGGGTCGTCCTG
ACCACAGGACAAGACAGCCAAAGCATCCAGAAAGCTCTCCAGCAGATTCGCCAGGCAGAT
AGAATTCGCATAATCATCATGTGTATGCATTCGACTTTGATTGGGGGAGAGACTCAGACG
CATCTCTTGGAATGGGCTCACGATCTGCAAATGACTGATGGCACCTATGTCTTTGTTCCC
TATGACACCCTGCTCTACAGTTTACCTTATAAGCATACCCCCTACAAGGTTTTAAGGAAC
AACCCAAAACTCCGGGAAGCCTATGATGCTGTGTTGACCATCACAGTAGAGTCCCAAGAA
AAGACCTTCTATCAAGCCTTTGAGGAGGCAGCAGCTAGAGGTGAAATTCCTGAGAAGCTG
GAGTCAGATCAAGTTTCGCCGTTGTTTGGAACCATCTACAATTCAATTTACTTTATCGCA
CAAGCCATGAATAATGCTATGAAAGAAAATGGATGGGCTAGTGCTGCCAGCCTGGTTCAG
CATTCCAGAAACGTGCAGTTCTATGGATTCAACCAGTTGATAAGGACAGATGCAAATGGA
AATGGAATTTCAGAATATGTAATCCTGGACACCAACTGGAAAGAATGGGAACTCCATAGT
ACCTACACTGTGGACATGGAAACGGAGCTGCTACGATTCGGAGAGACCCCTATTCACTTT
CCTGGTGGCAGGCCCCCTCGAGCAGATGCACAATGCTGGTTTGCAGATGGGAGGATCTGC
CAAGGAGGCATCAACCCTACTTTTGCTTTGATGGTCTGCCTTGCTTTGCTTATAGCCCTG
CTGTCTATTAATGGATTTGCTTACTTTATAAGACATCGTATAAATAAAATCCAGTTGATT
AAAGGACCCAACAGAATTCTACTGACTTTGGAGGATGTGACATTTATCAATCCCCACTTT
GGCAGTAAGAGAGGAAGTCATGCCAGTGTAAGTTTCCAGATCACGTCGGAGGTCCAGAGT
GGAAGGTCCCCAAGACTCTCCTTTTCTTCAGGGAGTCTAACTCCAGCTACCTGTGAAAAC
TCCAACATAGCGATTTATGAGGGTGATTGGGTATGGCTGAAAAAATTCCCCTCAGGAAAT
TTTGGAGACATTAAATCCGTCGAATCAAGTGCAAGTGACATATTTGAAATGATGAAGGAC
CTGCGTCATGAGAATATTAACCCTTTGGTGGGCTTCTTCTATGATTCGGGGGTATTTGCC
ATTGTGACAGAATTCTGTTCCCGAAGGAGCCTGGAAGACATACTGATGAATCAGGATGTG
AAACTAGATTGGATGTTTAAATCATCACTCCTGCTGGATCTCATCAAGGGCATGAAGTAC
TTACACCACAGAGAGTTTGCTCATGGGAGGCTGAAGTCTCGGAACTGTGTGGTGGATGGA
CGTTTTGTACTCAAAGTGACAGATTATGGCTTTAATGACATCTTGGAAACGCTAAGACTC
TCCCAAGAGGAACCTTCTGCAGAAGAGTTGCTGTGGACAGCCCCTGAACTGTTGAGAGCC
CCGAGGGGCAGCAGGTTACGTTCTTTTGCAGGAGACGTCTATAGCTTTGCCATCATCATG
CAGGAAGTGATGGTCCGGGGCACCCCATTCTGCATGATGGATCTACCTGCCAAAGAAATC
ATAGAAAGAATTAAGAAGCCTCCTCCAGTGTACAGACCAGTGGTTCCTCCTGAGCATGCA
CCCCCAGAATGTCTCCAGCTGATGAAGCAGTGCTGGGCTGAGGCTGCAGAACAACGACCA
ACATTTGATGAAATATTTAACCAGTTTAAAACTTTCAATAAAGGGAAGAAGACTAATATT
ATTGACTCTATGCTTCGGATGCTGGAGCAATATTCTAGCAACTTGGAAGATTTGATCCAG
GAGCGAACTGAAGAGCTGGAAATTGAAAAACAGAAAACGGAAAAGCTCCTAACACAGATG
CTCCCACCATCAGTTGCTGAATCTCTCAAAAAGGGCTGCACAGTCGAACCGGAGGGCTTT
GACTTGGTCACCTTGTACTTCAGCGACATTGTGGGCTTCACTACCATCTCAGCCATGAGT
GAGCCCATTGAGGTGGTGGATCTTCTCAATGACCTGTACACCCTCTTTGATGCCATCATT
GGCAGTCATGATGTCTACAAGGTAGAGACTATTGGAGATGCTTACATGGTGGCCTCAGGC
CTCCCAAAGAGGAATGGTATGAGGCATGCAGCTGAGATTGCAAACATGTCCCTAGACATC
CTCAGCTCTGTGGGTACCTTCAAGATGCGGCACATGCCAGAGGTGCCGGTCCGGATTCGA
ATAGGCCTGCACTCAGGGCCGGTTGTTGCTGGAGTGGTGGGCCTCACTATGCCCAGATAC
TGCTTGTTTGGAGATACTGTGAACACGGCTTCTCGGATGGAATCAACAGGGTTACCTTAT
CGCATTCATGTCAGTCATAGCACAGTGACAATTCTTCGAACCCTGGGTGAAGGCTATGAA
GTGGAGCTTCGAGGAAGAACAGAGCTCAAGGGCAAAGGCACAGAAGAGACCTTCTGGCTG
GTTGGGAAAAAGGGCTTCACGAAGCCCCTTCCTGTGCCCCCACCAGTGGGCAAAGATGGG
CAAGTGGGCCATGGCCTTCAGTCAGTAGAGATTGCAGCCTTCCAAAGAAGAAAGCAGAAA
AGCAGCTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1103 |
| Molecular Weight
| 124262.0 |
| Theoretical pI
| 6.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Retinal guanylyl cyclase 2
MFLAPWPFSHLMLWFVTLGRQRGQHGLASFKLLWCLWLLVLMSLPLQVWAPPYKIGVVGP
WTCDPLFSKALPEIAAQLATERINKDPALDLGHSLEYVIFNEDCQASRALSSFISHHQMA
SGFIGPANPGYCEAASLLGNSWDKGIFSWACVNYELDSKNSHPTFSRTLPSPIRVLLTVM
KYFQWAHAGVISSDEDIWVHTAYRVASALRSRGLPVGVVLTTGQDSQSIQKALQQIRQAD
RIRIIIMCMHSTLIGGETQTHLLEWAHDLQMTDGTYVFVPYDTLLYSLPYKHTPYKVLRN
NPKLREAYDAVLTITVESQEKTFYQAFEEAAARGEIPEKLESDQVSPLFGTIYNSIYFIA
QAMNNAMKENGWASAASLVQHSRNVQFYGFNQLIRTDANGNGISEYVILDTNWKEWELHS
TYTVDMETELLRFGETPIHFPGGRPPRADAQCWFADGRICQGGINPTFALMVCLALLIAL
LSINGFAYFIRHRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSHASVSFQITSEVQS
GRSPRLSFSSGSLTPATCENSNIAIYEGDWVWLKKFPSGNFGDIKSVESSASDIFEMMKD
LRHENINPLVGFFYDSGVFAIVTEFCSRRSLEDILMNQDVKLDWMFKSSLLLDLIKGMKY
LHHREFAHGRLKSRNCVVDGRFVLKVTDYGFNDILETLRLSQEEPSAEELLWTAPELLRA
PRGSRLRSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAKEIIERIKKPPPVYRPVVPPEHA
PPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIQ
ERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMS
EPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGMRHAAEIANMSLDI
LSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY
RIHVSHSTVTILRTLGEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDG
QVGHGLQSVEIAAFQRRKQKSSW
|
| External Links |
|---|
| GenBank ID Protein
| AAB53864.1 |
| UniProtKB/Swiss-Prot ID
| O02740 |
| UniProtKB/Swiss-Prot Entry Name
| GUC2F_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U95958 |
| GeneCard ID
| GUCY2F |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
