Showing Protein Fructose-2,6-bisphosphatase TIGAR (BMDBP01129)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01129 |
| Secondary Accession Numbers | None |
| Name | Fructose-2,6-bisphosphatase TIGAR |
| Synonyms | Not Available |
| Gene Name | TIGAR |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Carbohydrate transport and metabolism |
| Specific Function | Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity. In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage. Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses. Involved in intestinal tumor progression. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 5 |
| Locus | Not Available |
| SNPs | TIGAR |
| Gene Sequence |
>813 bp ATGACGCGCTTCGCTCTGACCGTGGTCCGGCATGGAGAAACAAGACTTAACAAGGAGAAA ATAATTCAAGGACAAGGAATAGATGAGCCTCTTTCAGAAACTGGATTTAAACAAGCAGCT GCTGCTGGTATATTTCTTAAAGATGTGAAGTTTACTCATGTTTTCTCCAGTGACCTTACA AGGACAAAGCAGACCGTGCATGGGATTTTGGAGAAGAGCAAATTTTGCAAAGATATGACA GTAAAGTATGATTCAAGACTCCGAGAAAGGAAATATGGGGTTGCAGAAGGCAGGCCGCTG AGCGAGCTGAGGGCCATGGCCAAAGCGGCAGGGGAGGAGTGCCCAGCATTCACACCGCCT GGAGGAGAGACCTTGGACCAGCTGAAAAGGCGTGGGAAAGACTTTTTTGAATTTCTTTGT CAACTGATCCTGAAAGAAGCCGGTCAGAATGAACAGTTTTCCCAGGAAGCCCCGAGCAGC TGTCTGGAAAGTTCCCTGGCAGAGATATTTCCTTTAGGGAAGAACTGTGCCTCCACGTTT AACTCTGACAGCGGCACCCCGGGCCTAGCAGCCAGTGTCTTAGTCGTGAGTCATGGCGCC TACATACGAAGCCTGTTGGATTACTTTCTGACTGACCTCAAGTGCTCGTTCCCAGCGACT CTGAGCAGGTCCGAGCTCACGTCAGTCAGCCCTAACACAGGGATGACTGTCTTCATCCTA AACTTTGAGAAAGGAGGCAAAGGGAGACCAACTGCCCAGTGTGTGTGTGTGAACCTCCAG GGCCACCTGGCCGGGGTGAACAAAACTCCCTAA |
| Protein Properties | |
| Number of Residues | 270 |
| Molecular Weight | 29467.0 |
| Theoretical pI | 8.57 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Probable fructose-2,6-bisphosphatase TIGAR MTRFALTVVRHGETRLNKEKIIQGQGIDEPLSETGFKQAAAAGIFLKDVKFTHVFSSDLT RTKQTVHGILEKSKFCKDMTVKYDSRLRERKYGVAEGRPLSELRAMAKAAGEECPAFTPP GGETLDQLKRRGKDFFEFLCQLILKEAGQNEQFSQEAPSSCLESSLAEIFPLGKNCASTF NSDSGTPGLAASVLVVSHGAYIRSLLDYFLTDLKCSFPATLSRSELTSVSPNTGMTVFIL NFEKGGKGRPTAQCVCVNLQGHLAGVNKTP |
| External Links | |
| GenBank ID Protein | AAI16102.1 |
| UniProtKB/Swiss-Prot ID | Q1JQA7 |
| UniProtKB/Swiss-Prot Entry Name | TIGAR_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC116101 |
| GeneCard ID | TIGAR |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |