Identification
BMDB Protein ID BMDBP01131
Secondary Accession Numbers None
Name Histidine ammonia-lyase
Synonyms Not Available
Gene Name HAL
Protein Type Enzyme
Biological Properties
General Function Amino acid transport and metabolism
Specific Function Not Available
Pathways
  • Amino-acid degradation
  • Ammonia Recycling
  • Histidine Metabolism
  • L-histidine degradation into L-glutamate
  • N-formimidoyl-L-glutamate from L-histidine: step 1/3
Reactions
L-Histidine → Ammonia + Urocanic acid details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 5
Locus Not Available
SNPs HAL
Gene Sequence
>1974 bp
ATGCCCAGGTACACGGTGCACGTTCGCGGAGAGTGGCTGGCCGTGCCCTGCCAGGACGCG
CAGCTCACGGTGGGCTGGCTGGGCCGGGAGGCTGTGCGGCGGTACATCAAGAACAAGCCT
GACAATGGTGGCTTCGCCTCGGTGGACGACGCCCGCTTCCTCGTGCGCCGCTGCAAAGGC
TTGGGCCTGCTGGACAATGAGGACCCACTGGACGTGGCCCTGGAGGACAATGAGTTCGTG
GAAGTGGTTATAGAAGGAGATGCTATGTCTCCCGACTTCATTCCCTCGCAGCCAGAAGGA
GTTTACTTATACAGCAAATACCGGGAACCCGAGAAGTACATCGCCTTAGATGGGGACAGT
CTGACCACAGAGGACCTGGTCAGCTTGGGCAAGGGACACTACAAAATCAAGCTTACCCCC
ACTGCTGAAAAGAGGGTGCAAAAATCCAGGGAAGTCATAGACAGAATCGTGGAAGAAAAA
ACTGTTGTTTACGGCATTACTACGGGTTTTGGGAAATTTGCCAGAACTGTAATTCCCGTC
AGTAAACTCGAGGAGCTCCAGTTCAACCTAGTACGTTCACATTCTTCAGGCGTTGGAAAA
CCACTAAGCCCTGAGAGATGCCGGATGCTCTTGGCTTTAAGGATCAATGTCTTAGCCAAA
GGATACAGTGGCATTTCCCTGGGGACCCTCAAACAAGTTATCGAAGTATTTAATGCCTCC
TGCCTGCCATATGTTCCAGAGAAAGGAACTGTTGGTGCCAGTGGAGACCTTGCCCCACTC
TCTCATCTTGCTCTTGGGCTGATTGGAGAAGGGAAGATGTGGTCTCCAAAGAGCGGCTGG
GCCGATGCTAAATACGTCCTCGCAGCTCATGGATTGAAGCCAATTGTTTTGAAACCAAAA
GAGGGTCTGGCACTCATCAATGGGACACAGATGATCACCTCCCTCGGCTGTGAGGCTGTG
GAGAGAGCCAGTGCCATCGCTCGGCAAGCTGACATAGTGGCGGCCTTGACCCTCGAGGTT
CTCAAGGGCACCACCAAAGCCTTCGATACTGACATTCACGCTGTTCGCCCTCATCGTGGG
CAAGTTGAAGTTGCTTTTCGGTTTCGGTCCCTCTTGGACTCGGATCACCACCCATCTGAA
ATAGCAGAAAGTCACAGGTTCTGCGATCGTGTTCAAGATGCATACACCTTGCGCTGCTGT
CCACAGGTCCATGGTGTGGTGAATGACACAATAGCATTTGTGAAGAACATCATAACCACG
GAAATTAACAGTGCAACAGATAACCCTATGGTCTTTGCCAGCAGGGGAGAGACTATTTCT
GGAGGAAACTTCCATGGTGAATATCCAGCCAAAGCCCTGGACTATTTGGCCATTGGTGTC
CATGAACTTGCCTCAATTAGTGAAAGAAGAATTGAAAGGCTCTGCAACCCCTCCCTCAGC
GAGCTGCCTGCCTTCCTGGTGGCTGAAGGTGGTCTGAATTCTGGATTCATGATAGCCCAC
TGCACCGCTGCAGCCCTGGTTTCTGAGAACAAGGCTCTGTGCCACCCCTCGTCTGTGGAT
TCTCTCTCCACCAGCGCTGCCACGGAGGATCACGTCTCCATGGGAGGATGGGCAGCAAGG
AAGGCCCTCAGGGTCATTGAGCATGTGGAGCAAGTGTTGGCCATCGAGCTTCTTGCAGCC
TGCCAGGGCATAGAGTTCCTCCGCCCCTTGAAAACCACCACTCCACTGGAGAAGGTCTAT
GACCTGGTGCGCTCTGTTGTGAGGCCCTGGATAAAAGATCGCTTCATGGCCCCAGACATC
GAGGCAGCGCACAGGCTGCTCGTAGAGCAGAAGGTTTGGGAAGTAGCTGCACCATACATT
GAAAAATACAGAATGGAGCATATTCCGGAATCAAGACCTGTTTCTCCAACAGCATTTTCA
CTGGAATTTCTGCACAAGAAATCTACCAAGATCCCAGAGTCTGAGGATCTTTAA
Protein Properties
Number of Residues 657
Molecular Weight 72291.0
Theoretical pI 6.68
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Histidine ammonia-lyase
MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFASVDDARFLVRRCKG
LGLLDNEDPLDVALEDNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIALDGDS
LTTEDLVSLGKGHYKIKLTPTAEKRVQKSREVIDRIVEEKTVVYGITTGFGKFARTVIPV
SKLEELQFNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLGTLKQVIEVFNAS
CLPYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLAAHGLKPIVLKPK
EGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHAVRPHRG
QVEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITT
EINSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELASISERRIERLCNPSLS
ELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAAR
KALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDI
EAAHRLLVEQKVWEVAAPYIEKYRMEHIPESRPVSPTAFSLEFLHKKSTKIPESEDL
GenBank ID Protein AAI34686.1
UniProtKB/Swiss-Prot ID A7YWP4
UniProtKB/Swiss-Prot Entry Name HUTH_BOVIN
PDB IDs Not Available
GenBank Gene ID BC134685
GeneCard ID HAL
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available