Showing Protein Presenilins-associated rhomboid-like protein, mitochondrial (BMDBP01133)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01133 |
| Secondary Accession Numbers | None |
| Name | Presenilins-associated rhomboid-like protein, mitochondrial |
| Synonyms | Not Available |
| Gene Name | PARL |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in serine-type peptidase activity |
| Specific Function | Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 1 |
| Locus | Not Available |
| SNPs | PARL |
| Gene Sequence |
>1134 bp ATGGCGTGGGGAGGCTGGGCGCAGAGAGGCTGGGGCTGTGGACAAGCGTGGACTCTGCCA GTGTGCGGCGGCAGCTATGAAGAGCTCACTGCGGCCCTGGCCCCGTCGCGGCTGCTCCGG CGCAGGTTTAACTTTTTTATTCAGCAAAAATGTGGATTCAGAAAAGCACCCAGGAAGGTT GAACCACGAAGATCGGACACAAGCAGTGAAGCGTACAAGAGAAGTGCTTTGATTCCTCCT GTAGAAGAAACAGCCTTTTACCCTTCTCCCTATCCTATAAGGACTCTTGTAAAGCCTTTG TTTTTTACTGTTGGGTTTACAGGCTGTGCATTTGGATCAGCTGCTATTTGGCAATATGAA TCACTGAAATCCAAGGTCCAAAGTTATTTTGATGGTATAAAAGCTGATTGGTTGGATAGC ATAAGACCGCAGAAGGAAGGAGACTTCAGAAAGGAGATTAACAAGTGGTGGAATAACCTA AGTGATGGCCAGCGGACTGTGACAGGTATCATAGCTGCAAATGTTTTTGTATTTTGTTTG TGGAGAGTACCTTCTCTGCAGCGGACAATGATCAGATACTTCACATCCAATCCAGCCTCA AAGGTCCTTTGTTCTCCAATGTTGCTGTCAACGTTCAGTCATTTCTCCTTGTTTCACATG GCAGCCAATATGTATGTCTTGTGGAGCTTCTCCTCCAGCATAGTGAACATTCTGGGTCAA GAGCAGTTCATGGCAGTATACTTATCTGCAGGTGTTATTTCCACTTTTGTCAGTTATGTG TGTAAAGTTGCCACAGGAAGATATGGACCATCACTTGGTGCATCTGGCGCAATCATGACT GTCCTTGCTGCCGTCTGCACTAAGATCCCGGAAGGGAGACTCGCCATCATCTTCCTTCCA ATGTTCACGTTCACAGCAGGGAATGCCCTAAAAGCCATTATTGCCATGGATACAGCAGGA ATGATCCTGGGATGGAAATTTTTTGATCATGCAGCACATCTTGGGGGAGCTCTCTTTGGA ATATGGTATATTACTTACGGTCATGAACTCATTTGGAAGAACAGGGAGCCTCTAGTGAAA ATTTGGCATGAAATGAGGACTAACAGCCCCAAAAAAGGAGGTGGCTCTAAGTAA |
| Protein Properties | |
| Number of Residues | 377 |
| Molecular Weight | 42301.0 |
| Theoretical pI | 10.24 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Presenilins-associated rhomboid-like protein, mitochondrial MAWRGWAQRGWGCGQAWTLPVCGGSYEELTAALAPSRLLRRRFNFFIQQKCGFRKAPRKV EPRRSDTSSEAYKRSALIPPVEETAFYPSPYPIRTLVKPLFFTVGFTGCAFGSAAIWQYE SLKSKVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVFVFCL WRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQ EQFMAVYLSAGVISTFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLP MFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVK IWHEMRTNSPKKGGGSK |
| External Links | |
| GenBank ID Protein | AAX08693.1 |
| UniProtKB/Swiss-Prot ID | Q2KHV4 |
| UniProtKB/Swiss-Prot Entry Name | PARL_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT020676 |
| GeneCard ID | PARL |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |