| Identification |
|---|
| BMDB Protein ID
| BMDBP01134 |
| Secondary Accession Numbers
| None |
| Name
| Histidine triad nucleotide-binding protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| HINT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| HINT1 |
| Gene Sequence
|
>381 bp
ATGGCTGATGAAATTGCTAAAGCTCAGGTCGCCCGGCCTGGCGGCGACACGATCTTCGGG
AAGATCATTCGCAAGGAAATCCCCGCCAAAATCATTTATGAGGATGACCAGTGTCTTGCT
TTCCATGACATTTCCCCTCAAGCACCAACACATTTTCTGGTGATACCCAAGAAATATATA
TCTGAGATTTCTGCAGCAGAAGATGATGATGAAAGTCTTCTTGGGCATTTGATGATTGTT
GGCAAGAAATGTGCTGCTGATCTGGGCCTGAAGAAAGGCTATCGAATGGTGGTGAATGAA
GGTTCAGATGGGGGCCAGTCTGTCTATCATGTTCATCTCCATGTTCTTGGAGGTCGGCAG
ATGAACTGGCCTCCTGGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 126 |
| Molecular Weight
| 13779.0 |
| Theoretical pI
| 6.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histidine triad nucleotide-binding protein 1
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIYEDDQCLAFHDISPQAPTHFLVIPKKYI
SQISAAEDDDESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHVHLHVLGGRQ
MNWPPG
|
| External Links |
|---|
| GenBank ID Protein
| AAA18396.1 |
| UniProtKB/Swiss-Prot ID
| P62958 |
| UniProtKB/Swiss-Prot Entry Name
| HINT1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| U09405 |
| GeneCard ID
| HINT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
