Showing Protein Histidine triad nucleotide-binding protein 1 (BMDBP01134)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01134 |
| Secondary Accession Numbers | None |
| Name | Histidine triad nucleotide-binding protein 1 |
| Synonyms | Not Available |
| Gene Name | HINT1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Nucleotide transport and metabolism |
| Specific Function | Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | HINT1 |
| Gene Sequence |
>381 bp ATGGCTGATGAAATTGCTAAAGCTCAGGTCGCCCGGCCTGGCGGCGACACGATCTTCGGG AAGATCATTCGCAAGGAAATCCCCGCCAAAATCATTTATGAGGATGACCAGTGTCTTGCT TTCCATGACATTTCCCCTCAAGCACCAACACATTTTCTGGTGATACCCAAGAAATATATA TCTGAGATTTCTGCAGCAGAAGATGATGATGAAAGTCTTCTTGGGCATTTGATGATTGTT GGCAAGAAATGTGCTGCTGATCTGGGCCTGAAGAAAGGCTATCGAATGGTGGTGAATGAA GGTTCAGATGGGGGCCAGTCTGTCTATCATGTTCATCTCCATGTTCTTGGAGGTCGGCAG ATGAACTGGCCTCCTGGTTAA |
| Protein Properties | |
| Number of Residues | 126 |
| Molecular Weight | 13779.0 |
| Theoretical pI | 6.79 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Histidine triad nucleotide-binding protein 1 MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIYEDDQCLAFHDISPQAPTHFLVIPKKYI SQISAAEDDDESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHVHLHVLGGRQ MNWPPG |
| External Links | |
| GenBank ID Protein | AAA18396.1 |
| UniProtKB/Swiss-Prot ID | P62958 |
| UniProtKB/Swiss-Prot Entry Name | HINT1_BOVIN |
| PDB IDs | |
| GenBank Gene ID | U09405 |
| GeneCard ID | HINT1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |