| Identification |
|---|
| BMDB Protein ID
| BMDBP01137 |
| Secondary Accession Numbers
| None |
| Name
| Acyl-protein thioesterase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| LYPLA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity). |
| Pathways
|
- Phospholipid Biosynthesis
|
| Reactions
|
| LysoPC(16:0/0:0) → Citicoline |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| LYPLA1 |
| Gene Sequence
|
>693 bp
ATGTGCGGCAATAACATGTCGGCTCCGCTGCCCGCCATCGTGCCTGCCGCCCGTAAGGCC
ACCGCCGCGGTGATCTTCCTTCATGGATTGGGAGACACAGGGCATGGATGGGCAGAAGCC
TTTGCCGGAATCAGAAGCGCCCACATCAAATACATCTGCCCGCATGCGCCGGTTATGCCT
GTAACATTAAATATGAACATGGCCATGCCATCATGGTTTGACATTATTGGGCTTTCGCCA
GATTCACTGGAGGATGAAACTGGAATTAAACAGGCAGCAGAAAATGTTAAAGCTTTGATA
GATCAAGAGGTGAAGAACGGCATTCCTTCTAACAGAATTATTTTGGGAGGATTTTCTCAG
GGAGGAGCTTTATCTCTGTACACGGCTCTGACCACACAGCAGAAGCTGGCCGGGGTCACC
GCTCTCAGCTGCTGGCTGCCACTGCGGGCTTCGTTTCCACAGGGCCCTATCGGTGGCGTG
AATAGAGACATTTCTATTCTTCAATGCCATGGGGACCTGGATCCTCTAGTCCCCCTGATG
TTCGGTTCTCTCACTGCTGAGAAGCTGAAGACATTGGTGAATCCAGCCAATGTGACCTTC
AGAACCTACGCAGGCATGATGCACAGTTCATGTCAACAGGAAATGATGGACATCAAGCAG
TTCATTGATAAGCTCCTACCTCCTGTTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 230 |
| Molecular Weight
| 24596.0 |
| Theoretical pI
| 6.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Acyl-protein thioesterase 1
MCGNNMSAPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSAHIKYICPHAPVMP
VTLNMNMAMPSWFDIIGLSPDSLEDETGIKQAAENVKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGVNRDISILQCHGDLDPLVPLM
FGSLTAEKLKTLVNPANVTFRTYAGMMHSSCQQEMMDIKQFIDKLLPPVD
|
| External Links |
|---|
| GenBank ID Protein
| AAI05144.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHR0 |
| UniProtKB/Swiss-Prot Entry Name
| LYPA1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC105143 |
| GeneCard ID
| LYPLA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
