Showing Protein Hydroxymethylglutaryl-CoA lyase, mitochondrial (BMDBP01139)
| Identification | |||||||
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| BMDB Protein ID | BMDBP01139 | ||||||
| Secondary Accession Numbers |
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| Name | Hydroxymethylglutaryl-CoA lyase, mitochondrial | ||||||
| Synonyms | Not Available | ||||||
| Gene Name | HMGCL | ||||||
| Protein Type | Enzyme | ||||||
| Biological Properties | |||||||
| General Function | Amino acid transport and metabolism | ||||||
| Specific Function | Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. | ||||||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||||||
| Cellular Location | Not Available | ||||||
| Gene Properties | |||||||
| Chromosome Location | 2 | ||||||
| Locus | Not Available | ||||||
| SNPs | HMGCL | ||||||
| Gene Sequence |
>978 bp ATGGCGACAGTGAAGAAGGTGCTCCCGCGGAGGCTGGTGGGCTTGGCGACCCTCCGGGCT GTCAGCACCTCATCTGTGGGTACGTTCCCAAAGCAAGTGAAAATTGTGGAAGTTGGTCCT CGAGACGGACTACAAAATGAAAAGAATATTGTACCTACTCCAGTGAAAATCAAGCTAATA GACATGCTTTCCGAAGCAGGACTCCCTGTGGTAGAAGCCACCAGCTTCGTGTCTCCCAAA TGGGTTCCACAGATGGCTGACCATGCTGAAGTCTTGAAAGGCATCCAGAAATTTCCTGGC GTCAACTACCCAGTCCTGACCCCAAACTTCAAAGGCTTCCAGGCAGCGGTTGCTGCCGGA GCCAAGGAAGTGGCCATCTTTGGAGCCGCCTCTGAACTCTTCACCAAGAAGAACATCAAC TGCTCCATAGATGAGAGTTTGCAGCGGTTTGATGAAATCTTGAAGGCAGCTCGGGCAGCC GGTATCTCTGTGCGGGGGTACGTCTCCTGTGTGCTTGGATGTCCCTACGAAGGGAAGATC TCCCCGGCTAAAGTCGCTGAGGTCACCAAGAAGCTGTACTCCATGGGCTGCTACGAGATC TCCCTGGGGGACACCATCGGCGTGGGCACCCCTGGGGCCATGAAGGACATGCTGTCTGCT GTCCTGCAGGAGGTGCCAGTGACAGCCCTGGCCGTCCACTGCCATGACACCTACGGCCAG GCCCTGGCCAACACCTTGACGGCCCTGCAGATGGGAGTGAGTGTCATGGACTCTTCCGTG GCAGGACTGGGAGGCTGTCCCTATGCACAGGGGGCGTCGGGAAACTTGGCCACCGAGGAC CTGGTCTACATGCTGGCCGGCCTGGGCATTCACACGGGTGTGAACCTCCAGAAGCTTCTG GAAGCTGGGGCCTTCATCTGTCAAGCCCTGAACAGAAGAACCAACTCCAAAGTGGCTCAG GCTACCTGTAAACTGTGA |
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| Protein Properties | |||||||
| Number of Residues | 325 | ||||||
| Molecular Weight | 34168.0 | ||||||
| Theoretical pI | 8.88 | ||||||
| Pfam Domain Function | Not Available | ||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||
| Protein Sequence |
>Hydroxymethylglutaryl-CoA lyase, mitochondrial MATVKKVLPRRLVGLATLRAVSTSSVGTFPKQVKIVEVGPRDGLQNEKNIVPTPVKIKLI DMLSEAGLPVVEATSFVSPKWVPQMADHAEVLKGIQKFPGVNYPVLTPNFKGFQAAVAAG AKEVAIFGAASELFTKKNINCSIDESLQRFDEILKAARAAGISVRGYVSCVLGCPYEGKI SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQ ALANTLTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL EAGAFICQALNRRTNSKVAQATCKL |
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| External Links | |||||||
| GenBank ID Protein | AAI18277.1 | ||||||
| UniProtKB/Swiss-Prot ID | Q29448 | ||||||
| UniProtKB/Swiss-Prot Entry Name | HMGCL_BOVIN | ||||||
| PDB IDs | Not Available | ||||||
| GenBank Gene ID | BC118276 | ||||||
| GeneCard ID | HMGCL | ||||||
| GenAtlas ID | Not Available | ||||||
| HGNC ID | Not Available | ||||||
| References | |||||||
| General References | Not Available | ||||||