Bovine Metabolome Database: Showing Protein Serine/threonine-protein kinase PAK 1 (BMDBP01142)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 metabolites

Identification

BMDB Protein ID

BMDBP01142

Secondary Accession Numbers

None

Name

Serine/threonine-protein kinase PAK 1

Synonyms

Not Available

Gene Name

PAK1

Protein Type

Enzyme

Biological Properties

General Function

Involved in ATP binding

Specific Function

Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion. In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (By similarity).

Pathways

FAS signaling pathway ( CD95 )
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
NF-kB Signaling Pathway
Rac 1 cell motility signaling pathway
Rac 1 Cell Motility Signaling Pathway

Reactions

Mitogen-activated protein kinase kinase kinase 1 → Mitogen-activated protein kinase kinase kinase 1 + Hydrogen phosphate	details
Dual specificity mitogen-activated protein kinase kinase 6 → Dual specificity mitogen-activated protein kinase kinase 6 + Hydrogen phosphate	details

GO Classification

Not Available

Cellular Location

Not Available

Gene Properties

Chromosome Location

Locus

Not Available

SNPs

PAK1

Gene Sequence

>1635 bp
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCTCCAGCCCCTCCGATGAGAAATACC
AGCACTATGATTGGAGCTGGCAGCAAAGACGCTGGAACCCTAAACCACGGTTCCAAACCT
CTGCCACCAAACCCAGAGGAAAAGAAAAAAAAGGACCGATTTTACCGAGCCATCTTACCT
GGAGATAAAACAAATAAAAAGAAGGAGAAGGAACGGCCAGAGATTTCTCTTCCTTCAGAT
TTTGAGCACACGATTCATGTTGGTTTTGATGCTGTCACAGGCGAGTTTACAGGGATGCCA
GAGCAATGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAAC
CCGCAGGCTGTTCTGGATGTGTTGGAATTTTATAACTCAAAGAAGACCTCCAACAGCCAG
AAGTATATGAGCTTTACAGATAAATCAGCTGAGGATTATAATTCTTCTAACACTTTGAAT
GTGAAGGCGGTGTCTGAGACCCCTGCAGTGCCACCAGTTTCAGAAGATGAAGATGATGAT
GATGATGGCACCCCACCCCCAGTGATTGCTCCACGCCCAGAGCACACAAAATCTGTATAC
ACACGGTCTGTGATTGAACCACTTCCTATTACTCCAACTCGGGATGTGGCTACATCTCCC
ATTTCACCTACTGAGAATAATACCACTCCACCTGATGCTCTGACTCGGAATACTGAGAAG
CAGAAGAAGAAGCCTAAGATGTCTGATGAGGAGATCTTGGAGAAATTACGCAGCATAGTG
AGTGTGGGTGATCCTAAGAAGAAATACACACGGTTTGAGAAGATTGGACAAGGTGCTTCG
GGCACTGTGTACACTGCAATGGATGTAGCCACAGGACAGGAGGTGGCCATTAAGCAGATG
AACCTTCAGCAGCAGCCGAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAA
AACAAGAACCCAAATATTGTGAACTACTTGGACAGTTACCTTGTGGGAGATGAGCTATGG
GTTGTCATGGAATATTTGGCTGGAGGTTCTTTGACAGACGTGGTAACAGAAACTTGCATG
GACGAAGGTCAGATTGCAGCTGTGTGCCGTGAGTGCCTGCAAGCTTTGGAGTTTCTGCAT
TCGAACCAAGTTATTCATAGAGACATCAAGAGTGACAACATCCTGTTGGGAATGGATGGC
TCTGTCAAGTTAACTGATTTTGGATTTTGTGCTCAGATCACCCCAGAGCAGAGCAAACGG
AGCACCATGGTGGGAACACCGTACTGGATGGCACCAGAGGTTGTAACCCGGAAAGCCTAT
GGGCCTAAGGTTGACATTTGGTCCTTGGGCATCATGGCCATTGAAATGATTGAAGGGGAG
CCCCCATACCTCAACGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACC
CCAGAGCTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGAGACTTTCTGAACCGCTGT
CTTGAGATGGATGTGGAGAAGAGAGGTTCGGCTAAAGAACTGCTGCAGCATCAATTTCTG
AAGATTGCCAAGCCTCTCTCCAGCCTCACTCCACTGATTGCTGCTGCAAAGGAAGCAACC
AAGAACAATCACTAA

Protein Properties

Number of Residues

544

Molecular Weight

60546.0

Theoretical pI

5.61

Pfam Domain Function

Not Available

Signals

None

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein kinase PAK 1
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRAILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKAVSETPAVPPVSEDEDDD
DDGTPPPVIAPRPEHTKSVYTRSVIEPLPITPTRDVATSPISPTENNTTPPDALTRNTEK
QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM
NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM
DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR
STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT
PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT
KNNH

External Links

GenBank ID Protein

AAI23417.1

UniProtKB/Swiss-Prot ID

Q08E52

UniProtKB/Swiss-Prot Entry Name

PAK1_BOVIN

PDB IDs