Showing Protein Dual specificity protein kinase CLK3 (BMDBP01144)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01144 |
| Secondary Accession Numbers | None |
| Name | Dual specificity protein kinase CLK3 |
| Synonyms | Not Available |
| Gene Name | CLK3 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 21 |
| Locus | Not Available |
| SNPs | CLK3 |
| Gene Sequence |
>1473 bp ATGCATCACTGTAAGCGATACCGCTCCCCTGAGCCAGACCCGTACCTGAGCTACCGATGG AAGAGGAGGAGGTCTTACAGTCGGGAGCACGAAGGGAGATTGCGATACCCGTCTCGAAGG GAGCCGCCGCCACGGAGATCTCGGTCTAGAAGCCATGACCGCTTGCCCTACCAGAGGAGA TACCGGGAGCACCGTGACAGCGACACATACCGGTGTGAAGACCGGAGCCCATCCTTTGGG GAGGACTACTACGGATCTTCACGTTGCCATCATCGTCGGCGATCACGGGAGAGGGAGCCA TACCGGACCCGCAAGCACGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGC GCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAG GAGGGCCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATATGAGATCGTGGGG AACCTGGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAGGGAAG TCTCAGGTTGCCCTGAAGATCATCCGCAATGTAGGCAAGTACCGGGAGGCCGCCCGGCTA GAAATCAACGTTCTCAAGAAGATCAAGGAGAAGGACAAAGAGAACAAGTTCCTGTGCGTC TTGATGTCTGACTGGTTCAACTTCCACGGTCACATGTGCATCGCCTTTGAGCTCCTGGGC AAGAACACCTTTGAGTTCCTAAAGGAGAATAACTTCCAGCCTTACCCTCTACCACATGTC CGGCACATGGCCTACCAGCTCTGCCACGCCCTTAGATTTCTACATGAGAACCAACTGACC CACACAGACTTGAAGCCAGAGAACATCCTGTTTGTGAATTCTGAGTTTGAAACCCTCTAC AATGAGCACAAGAGCTGTGAGGAGAAGTCAGTGAAGAACACCAGCATCCGAGTGGCTGAC TTCGGCAGTGCTACCTTTGACCATGAGCATCACACGACCATCGTGGCCACCCGTCACTAT CGTCCACCTGAGGTGATCCTTGAGCTGGGCTGGGCACAGCCGTGCGATGTCTGGAGCATC GGCTGCATTCTCTTTGAGTACTACCGGGGCTTCACACTCTTCCAGACCCACGAGAACCGA GAGCATTTGGTGATGATGGAGAAGATCCTAGGGCCCATCCCATCACACATGATCCACCGC ACAAGGAAGCAGAAATATTTCTACAAAGGGGGCCTGGTTTGGGATGAGAACAGTTCTGAC GGCCGGTATGTGAAGGAGAACTGCAAACCTCTGAAGAGTTATATGCTCCAAGACACTCTG GAGCACGTGCAGCTGTTTGACCTGATGAGGAGGATGTTAGAATTTGACCCTGCCCAGCGC ATCACACTGGCGGAGGCCCTGCTGCACCCCTTCTTTGCTGGTCTGACCCCTGAGGAGCGG TCCTTCCACACCAGCCGCAACCCAAGCAGATGA |
| Protein Properties | |
| Number of Residues | 490 |
| Molecular Weight | 58628.0 |
| Theoretical pI | 9.71 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Dual specificity protein kinase CLK3 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR YREHRDSDTYRCEDRSPSFGEDYYGSSRCHHRRRSREREPYRTRKHAHHCHKRRTRSCSS ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD GRYVKENCKPLKSYMLQDTLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER SFHTSRNPSR |
| External Links | |
| GenBank ID Protein | AAI04551.1 |
| UniProtKB/Swiss-Prot ID | Q3SX21 |
| UniProtKB/Swiss-Prot Entry Name | CLK3_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC104550 |
| GeneCard ID | CLK3 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |