Showing Protein Inhibitor of nuclear factor kappa-B kinase subunit beta (BMDBP01147)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP01147 | ||
| Secondary Accession Numbers | None | ||
| Name | Inhibitor of nuclear factor kappa-B kinase subunit beta | ||
| Synonyms | Not Available | ||
| Gene Name | IKBKB | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in ATP binding | ||
| Specific Function | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). | ||
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 27 | ||
| Locus | Not Available | ||
| SNPs | IKBKB | ||
| Gene Sequence |
>2271 bp ATGAGCTGGTCACCTTCCCTGCCAACCCAGACATGTGGGGCCTGGGAAATGAAAGAGCGT CTTGGGACAGGGGGATTTGGGAACGTCATCCGATGGCACAATCAGGAGACGGGCGAGCAG ATCGCCATCAAGCAGTGCCGGCAAGAGCTCAGTCCCCGGAACCGCGAGCGCTGGTGCCTG GAGATCCAGATCATGAGGAGGCTGAACCACCCCAATGTGGTGGCCGCCCGGGACGTCCCT GAAGGCATGCAGAGCCTGGCTCCCAACGACCTGCCCCTGCTGGCCATGGAGTACTGCCAG GGCGGGGACCTGCGCAAGTACCTGAACCAGTTTGAGAACTGCTGCGGCCTGCGGGAAGGA GCCATCCTCACCTTGCTGAGCGACATTGCCTCTGCACTTCGATACCTTCATGAGAACAGA ATCATCCATCGGGATCTGAAGCCAGAAAACATTGTCCTGCAGCAAGGGGAACAGAGATTA ATACACAAAATTATTGACCTGGGATACGCCAAGGAGCTGGACCAGGGCAGCCTCTGCACG TCCTTCGTGGGGACCCTGCAGTACCTGGCCCCCGAGCTGCTGGAGCAGCAGAAGTACACG GTGACCGTGGACTACTGGAGCTTCGGCACCTTGGCCTTCGAGTGCATCACCGGCTTCCGG CCTTTCCTGCCCAACTGGCAGCCCGTGCAGTGGCACTCCAAAGTCCGGCAGAAGAGCGAG ATGGACATTGTGGTGAGCGAGGACCTGAACGGGGCCGTGAAGTTCTCCAGCTCGCTGCCG CACCCCAACAACCTCAACAGCGTCCTGGCCCAGCGGCTGGAGAAGTGGCTGCAGCTGATG CTGATGTGGCACCCGCGCCAGAGGGGCACCGACCCTGTCTACGGGCCCAACGGCTGCTTC AAGGCCCTGGACGACATCTTGAACTTGAAGCTGCTTCATGTCCTGAACATGGTCACGGGC ACCCTGCACACCTACCCCGTGACCGAGGACGAGAGCCTGCAGAGCCTGAAGGCCCGCATC CGCCAGGACACAGGCATCCTCGAGGAGGACCAGGAGCTGCTGCAGGAGGCAGGGCTGGCC CTGATCCCCGACAAGCCTGCCGCCCAGTGCCTCTCGGACGGCAAGCTGAACGAGGGCCGC ACGCTGGACATGGACCTCGTTTTCCTCTTTGACAACAGCAGGGTCACCTATGAAAGCCAG GTCTCCCCACAGCCCCAGCCTGAAAGCGTCAGCTGCATCTTGCAAGAGCCCAAGAGGAAC CTCCCGTTCTTCCAGCTGCGGAAGGTGTGGGGCCAAGTCTGGCACAGCATCCAGGCCCTG AAGGAAGACTGCAGCCGCCTGCAGCAGGGCCAGCGCGCGGCCATGATGAATCTGCTGCGG AACAACAGCTGTCTGTCCAAGATGAAGAACTCCATGGCCTCCATGTCTCAGCAGCTCAAG GCCAAGCTGGACTTCTTTAAGACTAGTATCCAGATTGACCTGGAGAAGTACAGGGAGCAG ACGGAGTTTGGGATCACGTCGGACAAGCTGCTGCTAGCCTGGAGGGAGATGGAGCAGGCC GTGGAGCTCTGCGGACGGGAGAACGAGGTGAAGCACTTGGTGGAGCGGATGATGGCCCTG CAGACGGACATCGTGGACCTGCAGCGCAGCCCCATGGGCCGGAAGCAGGGCGGGACGCTG GATGATCTGGAAGAGCAGGCGCGGGAGCTTTACCGCAGGCTGAGGGAGAAGCCCAGAGAC CAGCGGACTGATGGTGACAGTCAGGAAATGGTGCGGCTGCTCCTCCAGGCAATCCAAGGC TTTGAGAAGAAAGTGCGAGTGATTTATACGCAGCTCAGTAAGACCGTGGTCTGCAAGCAG AAGGCCCTGGAACTGCTGCCCAAGGTGGAGGAGGTGGTCAGCCTGATGAGCGAGGACGAG AAGATGGTGGTGCGGCTGCAGGAGAAGCGGCAGAAGGAGCTCTGGAACCTCCTGAAGATT GCGTGTAGCAAGGTCCGGGGTCCCGTCAGCGGAAGCCCGGACAGTATGAACGCCTCCCGC CTGAGTCACCCCTGCCAGCTGATGTCACAGCCCTGCACGGCTCCCGACAGCTTGCCCGAG GCCGCCGAGAAGAGTGAGGACCTGGTGGCTGAAGCTCACACCCTGTGCACCCAGCTGGAG AACGCCCTGCAGGACACCATGAAGGAGCAGGACCAGAGTTTGAGGTCTCTAGACTGGAGC TGGTTGCAGTCGGAGGAGGAGGAACAGCAGAGCCTGGAGCGGGCCTCGTGA |
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| Protein Properties | |||
| Number of Residues | 756 | ||
| Molecular Weight | 86647.0 | ||
| Theoretical pI | 5.85 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Inhibitor of nuclear factor kappa-B kinase subunit beta MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE MDIVVSEDLNGAVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF KALDDILNLKLLHVLNMVTGTLHTYPVTEDESLQSLKARIRQDTGILEEDQELLQEAGLA LIPDKPAAQCLSDGKLNEGRTLDMDLVFLFDNSRVTYESQVSPQPQPESVSCILQEPKRN LPFFQLRKVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMSEDEKMVVRLQEKRQKELWNLLKI ACSKVRGPVSGSPDSMNASRLSHPCQLMSQPCTAPDSLPEAAEKSEDLVAEAHTLCTQLE NALQDTMKEQDQSLRSLDWSWLQSEEEEQQSLERAS |
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| External Links | |||
| GenBank ID Protein | CAC93687.1 | ||
| UniProtKB/Swiss-Prot ID | Q95KV0 | ||
| UniProtKB/Swiss-Prot Entry Name | IKKB_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AJ414556 | ||
| GeneCard ID | IKBKB | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||