Showing Protein Ribosomal protein S6 kinase beta-1 (BMDBP01152)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP01152 | ||
| Secondary Accession Numbers | None | ||
| Name | Ribosomal protein S6 kinase beta-1 | ||
| Synonyms | Not Available | ||
| Gene Name | RPS6KB1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in ATP binding | ||
| Specific Function | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition. | ||
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 19 | ||
| Locus | Not Available | ||
| SNPs | RPS6KB1 | ||
| Gene Sequence |
>1584 bp ATGAGGCGACGAAGGAGGCGGGACGGTTTCTACCCAGCGCCGGACTTCCGAGACAGGGAA GCTGAGGACATGGCAGGGGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCT GAGGATGAGCTGGAGGAGGGGGGTCAGTTAAATGAAAGCATGGACCATGGGGGGGTTGGA CCATATGAACTTGGCATGGAACATTGTGAGAAGTTTGAAATCTCAGAAACTAGTGTGAAC AGAGGGCCAGAAAAAATCAGACCAGAATGTTTTGAGCTCCTTCGAGTACTTGGTAAAGGG GGCTATGGAAAGGTTTTTCAAGTACGAAAAGTAACAGGAGCAAATACCGGGAAAATATTT GCCATGAAGGTGCTTAAAAAGGCAATGATAGTAAGAAATGCTAAAGATACAGCTCATACA AAAGCAGAACGGAATATTCTGGAGGAAGTAAAGCATCCTTTCATTGTGGATTTAATTTAT GCCTTTCAGACCGGTGGAAAACTCTACCTCATCCTTGAGTATCTCAGTGGAGGAGAATTA TTTATGCAGTTAGAAAGAGAAGGAATATTTATGGAAGACACAGCCTGCTTTTACTTGGCA GAAATCTCCATGGCTTTGGGGCATTTACATCAAAAGGGGATCATCTACAGAGACCTGAAG CCGGAGAATATCATGCTTAATCACCAAGGTCACGTCAAACTAACAGATTTTGGACTATGC AAAGAATCTATTCATGACGGAACAGTCACACACACCTTTTGTGGAACAATAGAATACATG GCCCCTGAGATCTTGATGAGAAGTGGCCACAATCGTGCTGTGGATTGGTGGAGTTTGGGA GCATTAATGTATGACATGCTGACTGGAGCACCCCCGTTCACTGGGGAGAATAGAAAGAAA ACAATTGACAAAATCCTCAAATGTAAACTCAATTTGCCTCCCTACCTCACGCAAGAAGCC AGAGATCTGCTTAAAAAGCTGCTGAAAAGAAATGCTGCTTCTCGTCTTGGAGCTGGTCCT GGGGATGCTGGAGAAGTTCAAGCTCATCCATTCTTCAGACATATTAACTGGGAAGAACTG CTGGCTCGGAAGGTGGAGCCCCCCTTCAAACCTCTTTTGCAATCAGAAGAGGATGTGAGT CAGTTTGATTCCAAGTTTACACGTCAGACACCTGTTGACAGCCCAGATGACTCAGCTCTC AGTGAAAGTGCCAACCAGGTCTTTCTGGGTTTTACATATGTGGCTCCATCTGTACTTGAA AGCGTGAAAGAAAAGTTTTCCTTTGAACCAAAAATCCGATCCCCTCGAAGATTTATTGGC AGCCCACGAACACCTGTCAGCCCAGTCAAATTTTCTCCTGGGGATTTCTGGGGAAGAGGT GCTTCAGCCAGCACGGCAAATCCGCAGACGCCTGTGGAATACCCCATGGAGACAAGTGGG ATAGAGCAGATGGACGTGACGATGAGCGGGGAGGCTTCAGCACCGCTTCCAATACGACAG CCAAACTCCGGACCGTACAAAAAACAAGCTTTTCCCATGATCTCCAAACGACCAGAGCAC CTGCGTATGAATCTAGAGCTCTGA |
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| Protein Properties | |||
| Number of Residues | 527 | ||
| Molecular Weight | 59352.0 | ||
| Theoretical pI | 6.52 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Ribosomal protein S6 kinase beta-1 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSALSESANQVFLGFTYVAPSVLE SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNLEL |
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| External Links | |||
| GenBank ID Protein | AAR01025.1 | ||
| UniProtKB/Swiss-Prot ID | Q6TJY3 | ||
| UniProtKB/Swiss-Prot Entry Name | KS6B1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AY396564 | ||
| GeneCard ID | RPS6KB1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||